The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
Open accessAbstract
BACKGROUND: Ebola virus has been detected in the semen of men after their recovery from Ebola virus disease (EVD). We report the presence of Ebola virus RNA in semen in a cohort of survivors of EVD in Sierra Leone. METHODS: We enrolled a convenience sample of 220 adult male survivors of EVD in Sierra Leone, at various times after discharge from an Ebola treatment unit (ETU), in two phases (100 participants were in phase 1, and 120 in phase 2). Semen specimens obtained at baseline were tested by means of a quantitative reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay with the use of the target sequences of NP and VP40 (in phase 1) or NP and GP (in phase 2). This study did not evaluate directly the risk of sexual transmission of EVD. RESULTS: Of 210 participants who provided an initial semen specimen for analysis, 57 (27%) had positive results on quantitative RT-PCR. Ebola virus RNA was detected in the semen of all 7 men with a specimen obtained within 3 months after ETU discharge, in 26 of 42 (62%) with a specimen obtained at 4 to 6 months, in 15 of 60 (25%) with a specimen obtained at 7 to 9 months, in 4 of 26 (15%) with a specimen obtained at 10 to 12 months, in 4 of 38 (11%) with a specimen obtained at 13 to 15 months, in 1 of 25 (4%) with a specimen obtained at 16 to 18 months, and in no men with a specimen obtained at 19 months or later. Among the 46 participants with a positive result in phase 1, the median baseline cycle-threshold values (higher values indicate lower RNA values) for the NP and VP40 targets were lower within 3 months after ETU discharge (32.4 and 31.3, respectively; in 7 men) than at 4 to 6 months (34.3 and 33.1; in 25), at 7 to 9 months (37.4 and 36.6; in 13), and at 10 to 12 months (37.7 and 36.9; in 1). In phase 2, a total of 11 participants had positive results for NP and GP targets (samples obtained at 4.1 to 15.7 months after ETU discharge); cycle-threshold values ranged from 32.7 to 38.0 for NP and from 31.1 to 37.7 for GP. CONCLUSIONS: These data showed the long-term presence of Ebola virus RNA in semen and declining persistence with increasing time after ETU discharge. (Funded by the World Health Organization and others.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Psychosocial effects of an Ebola outbreak at individual, community and international levels
Van Bortel, T., Basnayake, A., Wurie, F., Jambai, M., Koroma, A. S., Muana, A. T., Hann, K., Eaton, J., Martin, S., & Nellums, L. B. (2016) · Bulletin of the World Health Organization · doi:10.2471/blt.15.158543 · Cited by 471
Cited by
Lee, C. S., Bishop, E. S., Zhang, R., Yu, X., Farina, E. M., Yan, S., Zhao, C., Zeng, Z., Shu, Y., Wu, X., et al. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.04.001 · Cited by 691
Late Ebola virus relapse causing meningoencephalitis: a case report
Jacobs, M., Rodger, A., Bell, D. J., Bhagani, S., Cropley, I., Filipe, A., Gifford, R. J., Hopkins, S., Hughes, J., Jabeen, F., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30386-5 · Cited by 361
The evolution of Ebola virus: Insights from the 2013-2016 epidemic
Holmes, E. C., Dudas, G., Rambaut, A., & Andersen, K. G. (2016) · Nature · doi:10.1038/nature19790 · Cited by 314
Metadata
- Authors
- Deen, G. F., Broutet, N., Xu, W., Knust, B., Sesay, F. R., McDonald, S. L. R., Ervin, E., Marrinan, J. E., Gaillard, P., Habib, N., Liu, H., Liu, W., Thorson, A. E., Yamba, F., Massaquoi, T. A., James, F., Ariyarajah, A., Ross, C., Bernstein, K., Coursier, A., Klena, J., Carino, M., Wurie, A. H., Zhang, Y., Dumbuya, M. S., Abad, N., Idriss, B., Wi, T., Bennett, S. D., Davies, T., Ebrahim, F. K., Meites, E., Naidoo, D., Smith, S. J., Ongpin, P., Malik, T., Banerjee, A., Erickson, B. R., Liu, Y., Liu, Y., Xu, K., Brault, A., Durski, K. N., Winter, J., Sealy, T., Nichol, S. T., Lamunu, M., Bangura, J., Landoulsi, S., Jambai, A., Morgan, O., Wu, G., Liang, M., Su, Q., Lan, Y., Hao, Y., Formenty, P., Ströher, U., & Sahr, F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-10-12
- Volume
- 377
- Issue
- 15
- Pages
- 1428-1437
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2326558924
- Cited by
- 375
- References
- 1
- FWCI
- 37.58
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report. https://app.cochat.ai/papers/10.1056/nejmoa1511410
- The paper
- Deen, G. F., Broutet, N., Xu, W., Knust, B., Sesay, F. R., McDonald, S. L. R., Ervin, E., Marrinan, J. E., Gaillard, P., Habib, N., Liu, H., Liu, W., Thorson, A. E., Yamba, F., Massaquoi, T. A., James, F., Ariyarajah, A., Ross, C., Bernstein, K., . . . Sahr, F. (2017). Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1511410
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
