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Cited by 786

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome

Open access
Chen, Zi-Jiang, Shi, Yuhua, Sun, Yun, Zhang, Bo, Liang, Xiaoyan, Cao, Yunxia, Yang, Jing, Liu, Jiayin, Wei, Daimin, Weng, Ning, Tian, Lifeng, Hao, Cuifang, Yang, Dongzi, Zhou, Feng, Shi, Juanzi, Xu, Yongle, Li, Jing, Yan, Junhao, Qin, Yingying, Zhao, Han, Zhang, Heping, Legro, Richard S.·2016·New England Journal of Medicine
DOI 10.1056/nejmoa1513873
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Abstract

BACKGROUND: The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome. METHODS: In this multicenter trial, we randomly assigned 1508 infertile women with the polycystic ovary syndrome who were undergoing their first IVF cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer. After 3 days of embryo development, women underwent the transfer of up to two fresh or frozen embryos. The primary outcome was a live birth after the first embryo transfer. RESULTS: Frozen-embryo transfer resulted in a higher frequency of live birth after the first transfer than did fresh-embryo transfer (49.3% vs. 42.0%), for a rate ratio of 1.17 (95% confidence interval [CI], 1.05 to 1.31; P=0.004). Women who underwent frozen-embryo transfer also had a lower frequency of pregnancy loss (22.0% vs. 32.7%), for a rate ratio of 0.67 (95% CI, 0.54 to 0.83; P<0.001), and of the ovarian hyperstimulation syndrome (1.3% vs. 7.1%), for a rate ratio of 0.19 (95% CI, 0.10 to 0.37; P<0.001), but a higher frequency of preeclampsia (4.4% vs. 1.4%), for a rate ratio of 3.12 (95% CI, 1.26 to 7.73; P=0.009). There were no significant between-group differences in rates of other pregnancy and neonatal complications. There were five neonatal deaths in the frozen-embryo group and none in the fresh-embryo group (P=0.06). CONCLUSIONS: Among infertile women with the polycystic ovary syndrome, frozen-embryo transfer was associated with a higher rate of live birth, a lower risk of the ovarian hyperstimulation syndrome, and a higher risk of preeclampsia after the first transfer than was fresh-embryo transfer. (Funded by the National Basic Research Program of China and others; ClinicalTrials.gov number, NCT01841528.).

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Metadata

Authors
Chen, Z.-J., Shi, Y., Sun, Y., Zhang, B., Liang, X., Cao, Y., Yang, J., Liu, J., Wei, D., Weng, N., Tian, L., Hao, C., Yang, D., Zhou, F., Shi, J., Xu, Y., Li, J., Yan, J., Qin, Y., Zhao, H., Zhang, H., & Legro, R. S.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2016-08-11
Volume
375
Issue
6
Pages
523-533
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1513873
OpenAlex
W2505179618
Cited by
786
References
37
FWCI
66.34
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. https://app.cochat.ai/papers/10.1056/nejmoa1513873
The paper
Chen, Z.-J., Shi, Y., Sun, Y., Zhang, B., Liang, X., Cao, Y., Yang, J., Liu, J., Wei, D., Weng, N., Tian, L., Hao, C., Yang, D., Zhou, F., Shi, J., Xu, Y., Li, J., Yan, J., Qin, Y., . . . Legro, R. S. (2016). Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1513873

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.