CoChat
Sign Up
Cited by 819Neonatal Respiratory Health ResearchInfant Development and Preterm CarePreterm Birth and Chorioamnionitis

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Antenatal Betamethasone for Women at Risk for Late Preterm Delivery

Open access
Gyamfi-Bannerman, Cynthia, Thom, Elizabeth A., Blackwell, Sean C., Tita, Alan T.N., Reddy, Uma M., Saade, George R., Rouse, Dwight J., McKenna, David S., Clark, Erin A.S., Thorp, John M., Chien, Edward K., Peaceman, Alan M., Gibbs, Ronald S., Swamy, Geeta K., Norton, Mary E., Casey, Brian M., Caritis, Steve N., Tolosa, Jorge E., Sorokin, Yoram, VanDorsten, J. Peter, Jain, Lucky·2016·New England Journal of Medicine
DOI 10.1056/nejmoa1516783PMC PMC4823164
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities. METHODS: We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days). The participants were assigned to receive two injections of betamethasone or matching placebo 24 hours apart. The primary outcome was a neonatal composite of treatment in the first 72 hours (the use of continuous positive airway pressure or high-flow nasal cannula for at least 2 hours, supplemental oxygen with a fraction of inspired oxygen of at least 0.30 for at least 4 hours, extracorporeal membrane oxygenation, or mechanical ventilation) or stillbirth or neonatal death within 72 hours after delivery. RESULTS: The primary outcome occurred in 165 of 1427 infants (11.6%) in the betamethasone group and 202 of 1400 (14.4%) in the placebo group (relative risk in the betamethasone group, 0.80; 95% confidence interval [CI], 0.66 to 0.97; P=0.02). Severe respiratory complications, transient tachypnea of the newborn, surfactant use, and bronchopulmonary dysplasia also occurred significantly less frequently in the betamethasone group. There were no significant between-group differences in the incidence of chorioamnionitis or neonatal sepsis. Neonatal hypoglycemia was more common in the betamethasone group than in the placebo group (24.0% vs. 15.0%; relative risk, 1.60; 95% CI, 1.37 to 1.87; P<0.001). CONCLUSIONS: Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications. (Funded by the National Heart, Lung, and Blood Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development; ClinicalTrials.gov number, NCT01222247.).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejmoa1516783

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 82 references

Research works printed but not linked: 3

  1. 1994, NIH Consens Statement, 12, 1
  2. Roberts D, 2006, Cochrane Database Syst Rev, CD004454
  3. Martin JA, 2015, Natl Vital Stat Rep, 64, 1

Cited by

Sorted by citations

Items 601–700 of 819

Related

See all

Metadata

Authors
Gyamfi-Bannerman, C., Thom, E. A., Blackwell, S. C., Tita, A. T. N., Reddy, U. M., Saade, G. R., Rouse, D. J., McKenna, D. S., Clark, E. A. S., Thorp, J. M., Chien, E. K., Peaceman, A. M., Gibbs, R. S., Swamy, G. K., Norton, M. E., Casey, B. M., Caritis, S. N., Tolosa, J. E., Sorokin, Y., VanDorsten, J. P., & Jain, L.
Affiliations
  • From Columbia University, New York (C.G.-B.); the George Washington University Biostatistics Center, Washington, DC (E.A.T.); the University of Texas Health Science Center at Children’s Memorial Hermann Hospital, Houston (S.C.B.), the University of Texas Medical Branch, Galveston (G.R.S.), and the University of Texas Southwestern Medical Center, Dallas (B.M.C.) — all in Texas; the University of Alabama at Birmingham, Birmingham (A.T.N.T.); the Eunice Kennedy Shriver National Institute of Child Health and...
  • Memorial Hermann (US)
  • Northwestern University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2016-04-07
Volume
374
Issue
14
Pages
1311-1320
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1516783
PMC
PMC4823164
OpenAlex
W2321364247
Cited by
814
References
82
Citations by year
2026: 59 · 2025: 69 · 2024: 67 · 2023: 69 · 2022: 98 · 2021: 92 · 2020: 81 · 2019: 90 · 2018: 69 · 2017: 68 · 2016: 48
FWCI
81.34
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5ul1tr001067-05, UL1TR000040)
  • National Heart, Lung, and Blood Institute (R01HL098554, U01HL098554, R01HL098354, HL098554, HL098354, U01HL098354)
  • National Center for Advancing Translational Sciences (UL1-TR001067)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD68282, HD40512, HD53118, U01HD036801, HD27917, U10HD040544, U10HD034208, HD-27915, U10HD040512, HD34116, HD68268, UG1HD034116, HD40545, (HD40500, UG1HD053097, U10HD027915, HD68258, U10HD040545, U10HD040560, HD 40544, U10HD068268, HD40560, HD53097, U10HD027917, U10HD036801, U10HD021410, HD 34208, HD 36801, U10HD053097, U10HD034116, HD27869, UG1HD068282, [HD21410, UG1HD068258, U10HD040500, U10HD040485, U10HD053118, U10HD068282, U10HD027869, U10HD034136, UG1HD068268, U10HD068258, UG1HD034208, U24HD036801, UG1HD040500, UG1HD040512, UG1HD027869, UG1HD040544, UG1HD040485, UG1HD027915, UG1HD040560, UG1HD040545, HD 40485)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Keywords
betamethasone, antenatal corticosteroids, late preterm birth, neonatal respiratory distress, bronchopulmonary dysplasia, transient tachypnea of the newborn, neonatal hypoglycemia, neonatal sepsis, chorioamnionitis, neonatal mortality, surfactants
MeSH terms
Adult, Betamethasone, Bronchopulmonary Dysplasia, Female, Premature Rupture of Fetal Membranes, Gestational Age, Glucocorticoids, Humans, Hypoglycemia, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Injections, Intramuscular, Obstetric Labor, Premature, Oxygen Inhalation Therapy, Pregnancy, Pregnancy Trimester, Third, Pulmonary Surfactants, Respiration, Artificial, Respiratory Tract Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review