Cited by 831Mosquito-borne diseases and controlInfectious Encephalopathies and EncephalitisViral Infections and Vectors

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Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities

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Driggers, Rita W., Ho, Cheng-Ying, Korhonen, Essi M., Kuivanen, Suvi, Jääskeläinen, Anne J., Smura, Teemu, Rosenberg, Avi, Hill, D. Ashley, DeBiasi, Roberta L., Vezina, Gilbert, Timofeev, Julia, Rodriguez, Fausto J., Levanov, Lev, Razak, Jennifer, Iyengar, Preetha, Hennenfent, Andrew, Kennedy, Richard, Lanciotti, Robert, du Plessis, Adre, Vapalahti, Olli·2016·New England Journal of Medicine

DOI 10.1056/nejmoa1601824

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Abstract

Summ a r yThe current outbreak of Zika virus (ZIKV) infection has been associated with an apparent increased risk of congenital microcephaly.We describe a case of a pregnant woman and her fetus infected with ZIKV during the 11th gestational week.The fetal head circumference decreased from the 47th percentile to the 24th percentile between 16 and 20 weeks of gestation.ZIKV RNA was identified in maternal serum at 16 and 21 weeks of gestation.At 19 and 20 weeks of gestation, substantial brain abnormalities were detected on ultrasonography and magnetic resonance imaging (MRI) without the presence of microcephaly or intracranial calcifications.On postmortem analysis of the fetal brain, diffuse cerebral cortical thinning, high ZIKV RNA loads, and viral particles were detected, and ZIKV was subsequently isolated.Z ika virus (ZIKV), a mosquito-borne flavivirus and member of the Flaviviridae family, was originally isolated from a sentinel primate in Uganda in 1947. 1 ZIKV was associated with mild febrile disease and maculopapular rash in tropical Africa and some areas of Southeast Asia.Since 2007, ZIKV has caused several outbreaks outside its former distribution area in islands of the Pacific: in 2007 on Yap island in Micronesia, in 2013 and 2014 in French Polynesia, and in 2015 in South America, where ZIKV had not been identified previously.[2][3][4][5] There are separate African and Asian lineages of the virus, 6 and the latter strains have caused the outbreaks in the Pacific and the Americas.7 As in the transmission of dengue and chikungunya viruses, the main transmission cycle of ZIKV occurs between urban aedes mosquitoes and humans.One striking feature of the current ZIKV outbreak is the apparent increased risk of intrauterine or perinatal transmission of the virus as well as the marked increase in the number of newborns with microcephaly reported in Brazil.[8][9][10][11][12][13][14][15][16][17] A recent prospective study showed fetal ultrasonographic abnormalities in 12 of 42 women (29%) with ZIKV infection during pregnancy; 7 of the 42 fetuses (17%) that were studied had microcephaly, cerebral atrophy, or brain calcifications.11 Because of the association between ZIKV infection and microcephaly and other neurologic disorders, the World Health Organization has declared the ZIKV epidemic a public health emergency of international concern.13 Early in this particular outbreak, investigations into the viral pathogenesis, vertical transmission rates, potential viral cofactors, and sensitivity and specificity of diagnostic testing have presented more questions than answers.Nevertheless, the Centers for Disease Control and Prevention (CDC) has issued a travel advisory The authors' full names, academic degrees, and affiliations are listed in the Appendix.

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Zika Virus Outbreak on Yap Island, Federated States of Micronesia
Duffy, M. R., Chen, T.-H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805715 · Cited by 3,130
Self-citation
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
Zika Virus (I). Isolations and serological specificity
Dick, G. W. A., Kitchen, S. F., & Haddow, A. J. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90042-4 · Cited by 2,698
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Brasil, P., Pereira, J. P., Moreira, M. E. L., Nogueira, R. M. R., Damasceno, L. S., Wakimoto, M. D., Rabello, R. S., Gaw, S. L., Halai, U., Salles, T. R. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602412 · Cited by 2,192
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007
Lanciotti, R. S., Kosoy, O. L., Laven, J. J., Velez, J. O., Lambert, A. J., Johnson, A. J., Stanfield, S. M., & Duffy, M. R. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080287 · Cited by 2,173
Self-citation
Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?
Melo, A. S. O., Malinger, G., Ximenes, R., Szejnfeld, P. O., Sampaio, S. A., & de Filippis, A. M. B. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15831 · Cited by 1,180
Potential Sexual Transmission of Zika Virus
Musso, D., Roche, C., Robin, E., Nhan, T., Teissier, A., & Cao‐Lormeau, V. (2015) · Emerging infectious diseases · doi:10.3201/eid2102.141363 · Cited by 1,174
Probable Non–Vector-borne Transmission of Zika Virus, Colorado, USA
Foy, B. D., Kobylinski, K. C., Foy, J. C., Blitvich, B. J., da Rosa, A. T., Haddow, A. D., Lanciotti, R. S., & Tesh, R. B. (2011) · Emerging infectious diseases · doi:10.3201/eid1705.101939 · Cited by 1,157
Self-citation
Zika Virus, French Polynesia, South Pacific, 2013
Cao‐Lormeau, V., Roche, C., Teissier, A., Robin, E., Berry, A.-L., Mallet, H., Sall, A. A., & Musso, D. (2014) · Emerging infectious diseases · doi:10.3201/eid2006.140138 · Cited by 876
Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014
Besnard, M., Lastère, S., Teissier, A., Cao‐Lormeau, V., & Musso, D. (2014) · Eurosurveillance · doi:10.2807/1560-7917.es2014.19.13.20751 · Cited by 840

Show all 21 references

Research works printed but not linked: 8

Cao-Lormeau VM, 2014, Emerg Infect Dis, 20, 1085
2015, Wkly Epidemiol Rec, 90, 609
Lanciotti RS, Emerg Infect Dis
Brasil P, N Engl J Med
2016, Wkly Epidemiol Rec, 91, 73
Means and standard deviations of organ weights and measurements of live-born infants. In: Gilbert-Barness E, Debich-Spicer DE. Handbook of pediatric autopsy pathology. New York: Humana Press, 2005:54.
Venturi G, 2016, Euro Surveill, 21
Tang H, Cell Stem Cell

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Cong, X., Zhang, X., Gu, F., Tan, N., Huang, S., Jia, P., Su, J., Sun, C., Tan, Q., Fang, L., et al. (2026) · Journal of Medical Virology · doi:10.1002/jmv.70917 · Cited by 2
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Zhou, C., Cheng, M.-L., He, M.-J., Liu, Y., Li, Y.-Y., Xie, D.-Y., Chen, L., Li, D., Deng, Y.-Q., Xu, Y., et al. (2026) · Journal of Virology · doi:10.1128/jvi.00208-26 · Cited by 2
Impact of the Zika Virus for Anesthesiologists: A Review of Current Literature and Practices
Heller, B. J., Weiner, M. M., & Heller, J. A. (2016) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2016.11.042 · Cited by 2
Travel-Related Infections Among Pregnant Travellers to the Tropics: An Overview
Kong, L. Y., Libman, M., & Yansouni, C. P. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.08.006 · Cited by 2
Microcefalia asociada a infección congénita por Zika
Rosas, S. P. M., & Pérez, J. E. V. (2020) · Revista Med · doi:10.18359/rmed.3691 · Cited by 2
CARE Guidelines for Case Reports: Explanation and Elaboration Document. Translation into Russian
Riley, D. S., Barber, M. S., Kienle, G. S., Aronson, J. K., von Schoen-Angerer, T., Tugwell, P., Kiene, H., Helfand, M., Altman, D. G., Sox, H. C., et al. (2023) · Вопросы современной педиатрии · doi:10.15690/vsp.v22i2.2540 · Cited by 2
Predictors of Neurodevelopment in Microcephaly Associated with Congenital Zika Syndrome: A Prospective Study
de Mattos, A. M., Rastely-Junior, V. N., Pires, M. M., Ticona, J. P. A., Lessa, M. S. D. A., Regis, C., Wanderley, M., Leony, J., Bouzon, J., Ballalai, V., et al. (2023) · Children · doi:10.3390/children10121831 · Cited by 2
Mutation S139N on Zika virus prM protein shifts immune response from Asian to contemporary strain
Shang, J., Chao Hui, Z. H. O. U., He, M.-J., Huang, X., Qin, C., & Wu, A. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.02.012 · Cited by 2
Association between maternal chronic hepatitis B virus infection and the neurodevelopment of children: A comprehensive Korean cohort study
Park, Y., Heo, J., Kang, D., & Gwak, G. (2025) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2025.103116 · Cited by 2
Genomic variability in Zika virus in GBS cases in Colombia
Rivera-Franco, N., López, D., Castillo, A., Aristizábal, E., Puiu, D., Salzberg, S. L., Pardo, C., Parra, B., & on behalf of, N. E. A. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0313545 · Cited by 2
Zika Virus Update: More on an Emerging Arboviral Disease in the Western Hemisphere
Vest, K. G. (2016) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2016.105 · Cited by 2
Neuroimaging Findings of Congenital Zika Syndrome
Aragão, M. D. F. V. V., Brainer-Lima, A. M., de Holanda, A. C., & Petribu, N. C. D. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-53643-9_6 · Cited by 2
Congenital Viral Infections
Aly, G. S., Abdel‐Hady, H., & Ibrahim, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-54033-7_1 · Cited by 2
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Jang, J., & Ahn, I. (2017) · International Journal of Bio-Science and Bio-Technology · doi:10.14257/ijbsbt.2016.8.6.06 · Cited by 2
Animal Models for Chikungunya Virus and Zika Virus
Morrison, T. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811865-8.00010-6 · Cited by 2
Congenital Zika Syndrome
Moreira, M. E. L., & Richtmann, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-54391-0.00010-2 · Cited by 2
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Haese, N. N., Hirsch, A. J., & Streblow, D. N. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0581-3_16 · Cited by 3
RNA extraction techniques of different body fluids for Zika virus: Blood, genitourinary specimens, saliva, and other relevant fluids
Ronca, S. E., Gulas–Wroblewski, B. E., Kairis, R. B., & Murray, K. O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820267-8.00023-6 · Cited by 2
Congenital Zika syndrome and neuroimaging findings
Joob, B., Wiwanitkit, V., Ribeiro, B. N. D. F., Muniz, B. C., Gasparetto, E. L., Ventura, N., & Marchiori, E. D. S. (2017) · Radiologia Brasileira · doi:10.1590/0100-3984.2017.0206 · Cited by 2
Zika virus screening during pregnancy: Results and lessons learned from a screening program and a post‐delivery follow‐up analysis (2016–2022)
Arias, A. M., Valerio, L., Roure, S., Fernández‐Rivas, G., Rivaya, B., Pérez‐Olmeda, M. T., Soldevila, L., Parrón, I., Clotet, B., Vallès, X., et al. (2023) · Birth Defects Research · doi:10.1002/bdr2.2236 · Cited by 2
Zika virus
Nielsen‐Saines, K., Brasil, P., & Fuller, T. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-79525-8.00051-2 · Cited by 2
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Snodgrass, R., & Johanson, C. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-31889-9_38-1 · Cited by 2
Congenital Zika Virus Infection Paradigm: What is in the Wardrobe? A Narrative Review
Mirambo, M. M., Matemba, L. E., Majigo, M. V., & Mshana, S. E. (2019) · East Africa Science · doi:10.24248/easci.v1.iss1.13 · Cited by 2
Design and applications of catalytic metallodrugs containing the ATCUN motif
Yu, Z., & Cowan, J. A. (2019) · Advances in inorganic chemistry · doi:10.1016/bs.adioch.2019.10.005 · Cited by 2
Understanding Zika virus pathogenesis: an interview with Catherine Spong
Spong, C. Y. (2016) · BMC Medicine · doi:10.1186/s12916-016-0628-0 · Cited by 2
Infections of the Nervous System
Camelo-Piragua, S. I., & Hedley‐Whyte, E. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44585-6.00019-9 · Cited by 2
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McKenna, K. C. (2017) · The Linacre Quarterly · doi:10.1080/00243639.2017.1375065 · Cited by 2
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Russo, F. B., Toledo, C. M., Tocantins, F. R., Souza, G. V., & Beltrão-Braga, P. C. B. (2022) · Frontiers in Virology · doi:10.3389/fviro.2021.775361 · Cited by 1
The mechanisms of Zika virus-induced neuropathogenesis
Hassaan, N. A., & Xing, L. (2024) · Brazilian Journal of Microbiology · doi:10.1007/s42770-024-01543-3 · Cited by 1
Prolonged Zika Virus NS1 Protein Circulation in Patient Sera Impacts Clinical Outcome Before the Rise of a Specific IgM Response
Tamietti, C., Stephen, T., Rouvinski, A., Tenebray, B., Leparc‐Goffard, I., de Laval, F., Fernandes‐Pellerin, S., Manuguerra, J., Rey, F. A., Hasan, M., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70368 · Cited by 1
Simultaneous exposure to both Zika virus and household insecticides during pregnancy, and fetal growth and infant developmental behavior outcomes at 18 months, in Guadeloupe
Kadawathagedara, M., Muckle, G., Cordier, S., Michineau, L., Tressières, B., Mallard, A., Kovacic, L., Multigner, L., Quénel, P., & Chevrier, C. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114256 · Cited by 1
Prenatal Ultrasound Findings of Pregnancy Associated with Zika Virus Infection
Chen, Y.-N., Chen, C., Lin, C.-J., & Chen, S.-W. (2016) · Journal of Medical Ultrasound · doi:10.1016/j.jmu.2016.08.007 · Cited by 1
Prenatal brain MRI samples for development of automatic segmentation, target- recognition and machine-learning algorithms to detect anatomical structures
Gentillon, H., Stefańczyk, L., Strzelecki, M., & Respondek‐Liberska, M. (2017) · F1000Research · doi:10.12688/f1000research.10723.1 · Cited by 1
Outbreak of Zika Virus
Woo, J. J., Bae, J. H., Kang, J., & Lee, K. H. (2016) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2016.46.4.330 · Cited by 1
Histopathological Findings of Congenital Zika Syndrome
de Holanda, A. C., & de Mello, R. J. V. (2017) · Springer eBooks · doi:10.1007/978-3-319-53643-9_10 · Cited by 1
Zika Virus Infection during Pregnancy and its Management
Sarwar, M. R., & Saqib, A. (2017) · Cited by 1
Zika virus: What does a physician caring for children in Canada need to know?
Robinson, J. L. (2017) · Paediatrics & Child Health · doi:10.1093/pch/pxx012 · Cited by 1
Zika Virus Infection during Pregnancy; Maternofetal Risk Assessment, Transmission, Complications, and Management: A Review of the Literature
Sarwar, M. R., Saqib, A., & Iftikhar, S. (2018) · Archives of Clinical Infectious Diseases · doi:10.5812/archcid.12848 · Cited by 1
Zika prevention: lessons from the Australian front line
Mudd, J., Hollins, A., Ashton, S., Gair, R., & Donohue, S. D. (2018) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12814 · Cited by 1
Immunobiological aspects of vaccines in pregnancy: Maternal perspective
Chu, H. Y., & Marchant, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814582-1.00003-6 · Cited by 1

Authors: Driggers, R. W., Ho, C.-Y., Korhonen, E. M., Kuivanen, S., Jääskeläinen, A. J., Smura, T., Rosenberg, A., Hill, D. A., DeBiasi, R. L., Vezina, G., Timofeev, J., Rodriguez, F. J., Levanov, L., Razak, J., Iyengar, P., Hennenfent, A., Kennedy, R., Lanciotti, R., du Plessis, A., & Vapalahti, O.
Affiliations: Children's National (US)
Centers for Disease Control and Prevention (US)
ORCID: Ho, Cheng-Ying
Korhonen, Essi M.
Kuivanen, Suvi
Smura, Teemu
Rosenberg, Avi
DeBiasi, Roberta L.
Levanov, Lev
Hennenfent, Andrew
Kennedy, Richard
Vapalahti, Olli
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2016-06-02
Volume: 374
Issue: 22
Pages: 2142-2151
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1601824
OpenAlex: W2333018296
Cited by: 831
References: 21
Citations by year: 2026: 13 · 2025: 22 · 2024: 29 · 2023: 29 · 2022: 43 · 2021: 56 · 2020: 79 · 2019: 95 · 2018: 119 · 2017: 195 · 2016: 150
FWCI: 184.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
Keywords: Zika virus infection, congenital Zika syndrome, microcephaly, maternal viremia, fetal brain anomalies, intrauterine transmission, perinatal transmission, fetal head circumference, flavivirus, Zika virus outbreak, pregnancy complications, fetal brain MRI
MeSH terms: Zika Virus Infection, Zika Virus, Adult, Brain, Disease Outbreaks, Female, Fetus, Humans, Magnetic Resonance Imaging, Microcephaly, Pregnancy, Pregnancy Complications, Infectious, Viremia, Ultrasonography, Prenatal

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Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities

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