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Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
Open accessAbstract
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher. After CAR T-cell treatment, regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid. This clinical response continued for 7.5 months after the initiation of CAR T-cell therapy. (Funded by Gateway for Cancer Research and others; ClinicalTrials.gov number, NCT02208362 .).
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Metadata
- Authors
- Brown, C. E., Alizadeh, D., Starr, R., Weng, L., Wagner, J. R., Naranjo, A., Ostberg, J. R., Blanchard, M. S., Kilpatrick, J., Simpson, J., Kurien, A., Priceman, S. J., Wang, X., Harshbarger, T. L., D’Apuzzo, M., Ressler, J. A., Jensen, M. C., Barish, M. E., Chen, M., Portnow, J., Forman, S. J., & Badie, B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-12-29
- Volume
- 375
- Issue
- 26
- Pages
- 2561-2569
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2567424265
- Cited by
- 1,836
- References
- 0
- FWCI
- 67.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy. https://app.cochat.ai/papers/10.1056/nejmoa1610497
- The paper
- Brown, C. E., Alizadeh, D., Starr, R., Weng, L., Wagner, J. R., Naranjo, A., Ostberg, J. R., Blanchard, M. S., Kilpatrick, J., Simpson, J., Kurien, A., Priceman, S. J., Wang, X., Harshbarger, T. L., D’Apuzzo, M., Ressler, J. A., Jensen, M. C., Barish, M. E., Chen, M., . . . Badie, B. (2016). Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1610497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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