The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
A Randomized Trial of Endometrial Scratching before In Vitro Fertilization
Open accessAbstract
BACKGROUND: Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF). METHODS: We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysteroscopy). Participants were randomly assigned in a 1:1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle) or no intervention. The primary outcome was live birth. RESULTS: A total of 1364 women underwent randomization. The frequency of live birth was 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the control group (adjusted odds ratio, 1.00; 95% confidence interval, 0.78 to 1.27). There were no significant between-group differences in the rates of ongoing pregnancy, clinical pregnancy, multiple pregnancy, ectopic pregnancy, or miscarriage. The median score for pain from endometrial scratching (on a scale of 0 to 10, with higher scores indicating worse pain) was 3.5 (interquartile range, 1.9 to 6.0). CONCLUSIONS: Endometrial scratching did not result in a higher rate of live birth than no intervention among women undergoing IVF. (Funded by the University of Auckland and others; PIP Australian New Zealand Clinical Trials Registry number, ACTRN12614000626662 .).
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“although to date RCTs and meta-analyses in this patient group have failed to show a reduction in miscarriage rates.205,206”
From Recurrent MiscarriageGreen‐top Guideline No. 17 (2023) · cites this paper as [206]
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A nod is as good as a wink to a blind horse
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Reply: Endometrial scratching for women with repeated implantation failure
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Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Nastri CO, Gibreel A, Raine-Fenning N, et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2012;7:CD009517-CD009517.22786529
Cited by
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Endometrial function in women with polycystic ovary syndrome: a comprehensive review
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Capalbo, A., Poli, M., Rienzi, L. F., Girardi, L. D. C., Patassini, C., Fabiani, M., Cimadomo, D., Benini, F., Farcomeni, A., Cuzzi, J., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.002 · Cited by 271
Simón, C., Gómez, C., Cabanillas, S., Vladimirov, I. K., Castillón, G., Gilés, J., Boynukalin, K., Fındıklı, N., Bahçeci, M., Ortega, I., et al. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.06.002 · Cited by 189
Good practice recommendations on add-ons in reproductive medicine
ESHRE Add-ons working group, Lundin, K., Bentzen, J. G., Bozdağ, G., Ebner, T., Harper, J. C., Clef, N. L., Moffett, A., Norcross, S., Polyzos, N. P., et al. (2023) · Human Reproduction · doi:10.1093/humrep/dead184 · Cited by 177
Recurrent MiscarriageGreen‐top Guideline No. 17
Regan, L., Rai, R., Saravelos, S., Li, T., & the Royal College of Obstetricians and Gynaecologists (2023) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17515 · Cited by 158
Metadata
- Authors
- Lensen, S., Osavlyuk, D., Armstrong, S., Stadelmann, C., Hennes, A., Napier, E., Wilkinson, J., Sadler, L., Gupta, D., Strandell, A., Bergh, C., Vigneswaran, K., Teh, W. T., Hamoda, H., Webber, L., Wakeman, S. A., Searle, L., Bhide, P., McDowell, S., Peeraer, K., Khalaf, Y., & Farquhar, C.
- Affiliations
- University of Auckland (NZ)
- Royal Women's Hospital (AU)
- University College Hospital (GB)
- Guy's Hospital (GB)
- From the Department of Obstetrics and Gynaecology, University of Auckland (S.L., D.O., C.F.), and Women’s Health (L. Sadler) and Fertility Plus (D.G., C.F.), Auckland District Health Board, Auckland, Fertility Associates, Christchurch (S.A.W.), and Fertility Associates, Wellington (L. Searle, S.M.) — all in New Zealand; Bath Fertility Centre, Bath (S.A., E.N.), the Department of Medical Statistics, Manchester University NHS Foundation Trust, Manchester (J.W.), and the Department of Obstetrics and...
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2019-01-24
- Volume
- 380
- Issue
- 4
- Pages
- 325-334
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2913330914
- Cited by
- 198
- References
- 43
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 15 · 2023: 28 · 2022: 25 · 2021: 43 · 2020: 39 · 2019: 25
- FWCI
- 31.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- Maurice & Phyllis Paykel Trust
- Auckland District Health Board, New Zealand
- Nurture Foundation for Reproductive Health, New Zealand
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometrial scratching, Pipelle biopsy, in vitro fertilization, live birth, embryo implantation, pregnancy outcomes, procedural pain, frozen embryo transfer, fresh embryo transfer
- MeSH terms
- Adult, Embryo Transfer, Endometrium, Female, Fertilization in Vitro, Humans, Pain Measurement, Pregnancy, Odds Ratio, Treatment Outcome, Live Birth
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