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Cited by 1,312

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report

Open access
Mehra, Mandeep R., Uriel, Nir, Naka, Yoshifumi, Cleveland, Joseph C., Yuzefpolskaya, Melana, Salerno, Christopher T., Walsh, Mary N., Milano, Carmelo A., Patel, Chetan B., Hutchins, Steven W., Ransom, John, Ewald, Gregory A., Itoh, Akinobu, Raval, Nirav Y., Silvestry, Scott C., Cogswell, Rebecca, John, Ranjit, Bhimaraj, Arvind, Bruckner, Brian A., Lowes, Brian D., Um, John Y., Jeevanandam, Valluvan, Sayer, Gabriel, Mangi, Abeel A., Molina, Ezequiel J., Sheikh, Farooq, Aaronson, Keith, Pagani, Francis D., Cotts, William G., Tatooles, Antone J., Babu, Ashok, Chomsky, Don, Katz, Jason N., Tessmann, Paul B., Dean, David, Krishnamoorthy, Arun, Chuang, Joyce, Topuria, Ia, Sood, Poornima, Goldstein, Daniel J.·2019·New England Journal of Medicine
DOI 10.1056/nejmoa1900486
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Abstract

BACKGROUND: In two interim analyses of this trial, patients with advanced heart failure who were treated with a fully magnetically levitated centrifugal-flow left ventricular assist device were less likely to have pump thrombosis or nondisabling stroke than were patients treated with a mechanical-bearing axial-flow left ventricular assist device. METHODS: We randomly assigned patients with advanced heart failure to receive either the centrifugal-flow pump or the axial-flow pump irrespective of the intended goal of use (bridge to transplantation or destination therapy). The composite primary end point was survival at 2 years free of disabling stroke or reoperation to replace or remove a malfunctioning device. The principal secondary end point was pump replacement at 2 years. RESULTS: This final analysis included 1028 enrolled patients: 516 in the centrifugal-flow pump group and 512 in the axial-flow pump group. In the analysis of the primary end point, 397 patients (76.9%) in the centrifugal-flow pump group, as compared with 332 (64.8%) in the axial-flow pump group, remained alive and free of disabling stroke or reoperation to replace or remove a malfunctioning device at 2 years (relative risk, 0.84; 95% confidence interval [CI], 0.78 to 0.91; P<0.001 for superiority). Pump replacement was less common in the centrifugal-flow pump group than in the axial-flow pump group (12 patients [2.3%] vs. 57 patients [11.3%]; relative risk, 0.21; 95% CI, 0.11 to 0.38; P<0.001). The numbers of events per patient-year for stroke of any severity, major bleeding, and gastrointestinal hemorrhage were lower in the centrifugal-flow pump group than in the axial-flow pump group. CONCLUSIONS: Among patients with advanced heart failure, a fully magnetically levitated centrifugal-flow left ventricular assist device was associated with less frequent need for pump replacement than an axial-flow device and was superior with respect to survival free of disabling stroke or reoperation to replace or remove a malfunctioning device. (Funded by Abbott; MOMENTUM 3 ClinicalTrials.gov number, NCT02224755.).

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Metadata

Authors
Mehra, M. R., Uriel, N., Naka, Y., Cleveland, J. C., Yuzefpolskaya, M., Salerno, C. T., Walsh, M. N., Milano, C. A., Patel, C. B., Hutchins, S. W., Ransom, J., Ewald, G. A., Itoh, A., Raval, N. Y., Silvestry, S. C., Cogswell, R., John, R., Bhimaraj, A., Bruckner, B. A., Lowes, B. D., Um, J. Y., Jeevanandam, V., Sayer, G., Mangi, A. A., Molina, E. J., Sheikh, F., Aaronson, K., Pagani, F. D., Cotts, W. G., Tatooles, A. J., Babu, A., Chomsky, D., Katz, J. N., Tessmann, P. B., Dean, D., Krishnamoorthy, A., Chuang, J., Topuria, I., Sood, P., & Goldstein, D. J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2019-04-25
Volume
380
Issue
17
Pages
1618-1627
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1900486
OpenAlex
W2922229775
Cited by
1,312
References
13
FWCI
55.73
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report. https://app.cochat.ai/papers/10.1056/nejmoa1900486
The paper
Mehra, M. R., Uriel, N., Naka, Y., Cleveland, J. C., Yuzefpolskaya, M., Salerno, C. T., Walsh, M. N., Milano, C. A., Patel, C. B., Hutchins, S. W., Ransom, J., Ewald, G. A., Itoh, A., Raval, N. Y., Silvestry, S. C., Cogswell, R., John, R., Bhimaraj, A., Bruckner, B. A., . . . Goldstein, D. J. (2019). A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1900486

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.