Cited by 890Respiratory Support and MechanismsAnesthesia and Sedative AgentsIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

Open access

The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network·2019·New England Journal of Medicine

DOI 10.1056/nejmoa1901686PMC PMC6741345

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear. METHODS: We randomly assigned patients with moderate-to-severe ARDS (defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure [PEEP] of ≥8 cm of water) to a 48-hour continuous infusion of cisatracurium with concomitant deep sedation (intervention group) or to a usual-care approach without routine neuromuscular blockade and with lighter sedation targets (control group). The same mechanical-ventilation strategies were used in both groups, including a strategy involving a high PEEP. The primary end point was in-hospital death from any cause at 90 days. RESULTS: The trial was stopped at the second interim analysis for futility. We enrolled 1006 patients early after the onset of moderate-to-severe ARDS (median, 7.6 hours after onset). During the first 48 hours after randomization, 488 of the 501 patients (97.4%) in the intervention group started a continuous infusion of cisatracurium (median duration of infusion, 47.8 hours; median dose, 1807 mg), and 86 of the 505 patients (17.0%) in the control group received a neuromuscular blocking agent (median dose, 38 mg). At 90 days, 213 patients (42.5%) in the intervention group and 216 (42.8%) in the control group had died before hospital discharge (between-group difference, -0.3 percentage points; 95% confidence interval, -6.4 to 5.9; P = 0.93). While in the hospital, patients in the intervention group were less physically active and had more adverse cardiovascular events than patients in the control group. There were no consistent between-group differences in end points assessed at 3, 6, and 12 months. CONCLUSIONS: Among patients with moderate-to-severe ARDS who were treated with a strategy involving a high PEEP, there was no significant difference in mortality at 90 days between patients who received an early and continuous cisatracurium infusion and those who were treated with a usual-care approach with lighter sedation targets. (Funded by the National Heart, Lung, and Blood Institute; ROSE ClinicalTrials.gov number, NCT02509078.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1901686

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)
Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., Bonsel, G., & Badia, X. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9903-x · Cited by 9,795
Acute Respiratory Distress Syndrome
Ards Definition Task Force (2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 9,066
Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries.
Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766
Identification of Causal Effects Using Instrumental Variables
Angrist, J. D., Imbens, G. W., & Rubin, D. B. (1996) · Journal of the American Statistical Association · doi:10.1080/01621459.1996.10476902 · Cited by 4,230
Prone positioning in severe acute respiratory distress syndrome.
Guérin, C., Reignier, J., Richard, J.-C., Beuret, P., Gacouin, A., Boulain, T., Mercier, E., Badet, M., Mercat, A., Baudin, O., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214103 · Cited by 4,040
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
Barr, J., Fraser, G. L., Puntillo, K., Ely, E. W., Gélinas, C., Dasta, J. F., Davidson, J. E., Devlin, J. W., Kress, J. P., Joffe, A. M., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182783b72 · Cited by 3,896

Flagged first, then by citations

Show all 47 references

Sorted by citations

Items 501–600 of 890

Rescue Neuromuscular Blockade in Acute Respiratory Distress Syndrome Should Be Flat Dose
Co, I. N., & Hyzy, R. C. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000004198 · Cited by 4
Short-term survival of acute respiratory distress syndrome patients due to influenza virus infection alone: a cohort study
Gacouin, A., Lesouhaitier, M., Reizine, F., Pronier, C., Grégoire, M., Painvin, B., Maamar, A., Thibault, V., Tulzo, Y. L., & Tadié, J. (2020) · ERJ Open Research · doi:10.1183/23120541.00587-2020 · Cited by 4
Principio de proporcionalidad terapéutica en la decisión de intubación orotraqueal y ventilación mecánica invasiva en paciente COVID-19 grave
Rubio, R. D. C. (2021) · Acta Colombiana de Cuidado Intensivo · doi:10.1016/j.acci.2020.12.003 · Cited by 4
Bedside clinical data subphenotypes of critically ill COVID-19 patients: a cohort study
Ururahy, R. D. R., Gallo, C. A., Besen, B. A. M. P., de Carvalho, M. T., Ribeiro, J. M. D. F. P., Zigaib, R., Mendes, P. V., & Park, M. (2021) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20210027 · Cited by 4
In Response
Hanidziar, D., & Bittner, E. A. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005132 · Cited by 4
Improving delivery of low tidal volume ventilation in 10 ICUs
Donadee, C., Cohen-Melamed, M. H., Delgado, E., & Gunn, S. R. (2022) · BMJ Open Quality · doi:10.1136/bmjoq-2021-001343 · Cited by 5
Current Practice Review in the Management of Acute Respiratory Distress Syndrome
Chudow, M. B., Condeni, M. S., Dhar, S., Heavner, M. S., Nei, A. M., & Bissell, B. D. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221108713 · Cited by 4
Prognostic value of the novel P/FPE index to classify ARDS severity: A cohort study
Martos-Benítez, F. D., Muguercia, R. E., Orama-Requejo, V., & del Toro-Simoni, T. (2022) · Medicina Intensiva · doi:10.1016/j.medin.2022.06.006 · Cited by 4
Improved understanding of the respiratory drive pathophysiology could lead to earlier spontaneous breathing in severe acute respiratory distress syndrome
Petitjeans, F., Leroy, S., Pichot, C., GHIGNONE, M., Quintin, L., Longrois, D., & Constantin, J. (2023) · European Journal of Anaesthesiology Intensive Care · doi:10.1097/ea9.0000000000000030 · Cited by 4
Inhaled epoprostenol utilization pattern after implementation of an administration policy
Collier, T. E., Kataria, V. K., & Modrykamien, A. M. (2019) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2019.1668668 · Cited by 4
Kritikus állapotú, légzéstámogatást igénylő COVID–19-fertőzött beteg ellátásának gyakorlati szempontjai
Végh, T., László, I., Juhász, M., Berhés, M., Fábián, Á., Koszta, G., Molnár, C., & Fülesdi, B. (2020) · Orvosi Hetilap · doi:10.1556/650.2020.31810 · Cited by 4
A narrative review of driving pressure as a monitoring indicator during mechanical ventilation with spontaneous breathing
Yu, X., & Pan, J. (2020) · Annals of Palliative Medicine · doi:10.21037/apm-19-284 · Cited by 4
CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION (2021)
Дмитрівна, С. І. (2021) · ДЕРЖАВНА НАУКОВА УСТАНОВА «НАУКОВО-ПРАКТИЧНИЙ ЦЕНТР ПРОФІЛАКТИЧНОЇ І КЛІНІЧНОЇ МЕДИЦИНИ» eBooks · doi:10.31612/covid · Cited by 4
Modeling current practices in critical care comparative effectiveness research
Applefeld, W. N., Wang, J., Cortés‐Puch, I., Klein, H. G., Eichacker, P. Q., Cooper, D., Danner, R. L., & Natanson, C. (2022) · Critical Care and Resuscitation · doi:10.51893/2022.2.oa5 · Cited by 4
Personalized medicine targeting different ARDS phenotypes: The future of pharmacotherapy for ARDS?
Blanchard, F., James, A., Assefi, M., Kapandji, N., & Constantin, J. (2023) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2023.2176302 · Cited by 4
A Framework for Developing a Multidisciplinary Approach to Prone Positioning in Acute Respiratory Distress Syndrome
Gohar, A., Kirupaharan, P., Amaral, V., Kokoczka, L. M., Mireles‐Cabodevila, E., Mucha, S. R., & Duggal, A. (2023) · Journal of Intensive Care Medicine · doi:10.1177/08850666231162566 · Cited by 4
Differences in Ventilation Management and Outcomes between the Two First Waves of the COVID-19 Pandemic—A Comparison between Two Nationwide Observational Studies in The Netherlands
Hol, L., Schultz, M. J., Martín‐Loeches, I., van Meenen, D. M. P., Neto, A. S., Paulus, F., & PRoAcT-COVID Investigators (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134507 · Cited by 4
Experimental asynchrony to study self-inflicted lung injury
Cronin, J. N., & Formenti, F. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.11.020 · Cited by 4
Refining the use of neuromuscular blockade in ARDS: lessons from a post hoc Markov model re-analysis of the ACURASYS trial
Lakbar, I., JONG, A. D., & Battaglini, D. (2025) · Intensive Care Medicine · doi:10.1007/s00134-025-08183-7 · Cited by 4
Extracellular purines in lung endothelial permeability and pulmonary diseases
Gerasimovskaya, E. V., Patil, R. S., Davies, A., Maloney, M. E., Simon, L., Mohamed, B., Cherian‐Shaw, M., & Verin, A. D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1450673 · Cited by 3
Acute respiratory distress syndrome: Why a definition matters
Girard, C., Sadana, D., Giovanni, S. P., Torbic, H., & Duggal, A. (2025) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.92a.24115 · Cited by 3
Neuromuscular blockade and their monitoring in the intensive care unit: a multicenter observational prospective study
Hermann, B., Decormeille, G., Gobé, T., Mangeard, N., Maamar, A., Sayadi, S., Pernod, B., Robquin, N., Ponthus, J., Potier, S. L., et al. (2025) · Annals of Intensive Care · doi:10.1186/s13613-025-01591-4 · Cited by 3
Smart nebulized ROS-responsive hydrogel microspheres loaded with UC-MSCs-derived exosomes for the treatment of acute lung injury
Liu, C., Xiang, G., Cao, Y., Xu, J., Hu, X., Deng, S., Xiao, K., & Xie, L. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102868 · Cited by 3
The ARDS, Pneumonia, and Sepsis Consortium
Self, W. H., Calfee, C. S., Brown, S. M., Moss, M., Ware, L. B., Hyzy, R. C., Meyer, N. J., Reilly, J. P., Harhay, M. O., Shashaty, M. G. S., et al. (2026) · CHEST Journal · doi:10.1016/j.chest.2026.05.053 · Cited by 3
Diaphragm-Protective Mechanical Ventilation: Saving the Diaphragm from the Detrimental Effects of Mechanical Ventilation
Shi, Z., Zhou, J.-X., & Heunks, L. M. A. (2022) · Journal of Translational Critical Care Medicine · doi:10.4103/jtccm-d-21-00017 · Cited by 3
A Comparison of Midazolam and Propofol for Deep Sedation in Patients with Acute Respiratory Distress Syndrome Requiring Neuromuscular Blocking Agents
Addison, J. D., Daley, M. J., Curran, M., & Hodge, E. K. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221131420 · Cited by 3
Potential Impact of Subphenotyping in Pharmacologic Management of Acute Respiratory Distress Syndrome
Torbic, H., Bulgarelli, L., Deliberato, R. O., & Duggal, A. (2023) · Journal of Pharmacy Practice · doi:10.1177/08971900231185392 · Cited by 3
Neuromuscular Blocking Agent Use in Critical Care Transport Not Associated With Intubation
Esteves, A. M., Fjeld, K. J., Yonan, A. S., & Roginski, M. A. (2024) · Air Medical Journal · doi:10.1016/j.amj.2024.03.003 · Cited by 3
Hub genes identification and validation of ferroptosis in SARS-CoV-2 induced ARDS: perspective from transcriptome analysis
Li, Y., Tang, L., Wang, F., Gao, C., Yang, Q., Luo, L., Wei, J., Tang, Q., & Qi, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1407924 · Cited by 3
Electroacupuncture pretreatment ameliorates Golgi stress and the inflammation response against endotoxin-induced lung injury
Guo, C., Zhang, Y., Kong, C., Liu, W., Li, M., Yang, J., Sun, J., Wang, Y., & Yu, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113868 · Cited by 3
Inter-rater Agreement of Richmond Agitation Sedation Scale Assessments in Adult Patients Receiving Mechanical Ventilation in the ICU: A Cross-Sectional Study
Fuchita, M., Pattee, J. W., Le, D., To, T., Mucharraz, C., Knippa, S., Keyworth, A., Blaine, C., & Lindroth, H. L. (2025) · Critical Care Explorations · doi:10.1097/cce.0000000000001302 · Cited by 3
„Acute respiratory distress syndrome“
Kersten, A., & Cornelissen, C. G. (2020) · Der Pneumologe · doi:10.1007/s10405-020-00326-5 · Cited by 3
Comparison of Ventilator-Free Days at 14 and 28 days as a Clinical Trial Outcome in Low- and Middle-Income Countries
Baranwal, A. K., Kumar, P. M., & Gupta, P. (2020) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23568 · Cited by 3
Critical care essentials for pharmacy trainees and new clinical practitioners
Erstad, B. L., Kiser, T. H., & Bauer, S. R. (2020) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxaa417 · Cited by 4
Current Standards and Practices in Small Animal Mechanical Ventilation
Balakrishnan, A. (2021) · Advances in Small Animal Care · doi:10.1016/j.yasa.2021.07.006 · Cited by 4
The role of extracorporeal membrane oxygenation in COVID-19
Dalia, A. A., Convissar, D. L., Crowley, J., Raz, Y., Funamoto, M., Wiener-Kronish, J. P., & Shelton, K. (2022) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2022.05.010 · Cited by 3
Dynamic evaluation of the pulmonary protective effects of prone position ventilation via respiratory mechanics for patients with moderate to severe acute respiratory distress syndrome
Jiang, Z., Zhang, Z., Sun, Q., Zhang, B., Deng, Q., Yin, X., He, W., Liu, X., Xu, Y., & Chen, T. (2022) · Journal of Thoracic Disease · doi:10.21037/jtd-22-291 · Cited by 3
Costo-efectividad de la oxigenación con membrana extracorpórea en pacientes con síndrome de dificultad respiratoria aguda en Colombia
García, A., & Giraldo, N. D. (2022) · Biomédica · doi:10.7705/biomedica.6386 · Cited by 3
The depth of neuromuscular blockade is not related to chest wall elastance and respiratory mechanics in moderate to severe acute respiratory distress syndrome patients. A prospective cohort study
Barbarot, N., Tinelli, A., Fillâtre, P., Débarre, M., Magalhaes, É., Massart, N., Wallois, J., Legay, F., & Mari, A. (2023) · Journal of Critical Care · doi:10.1016/j.jcrc.2023.154505 · Cited by 3
Hypoxemic Respiratory Failure and Coccidioidomycosis-Associated Acute Respiratory Distress Syndrome
Heidari, A., Kaur, S., Pearson, S. J., Munoz, A., Sandhu, H., Mann, G., Schivo, M., Zeki, A. A., Bays, D. J., Wilson, M., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad679 · Cited by 3
Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis
Lin, K., Fang, W., Yeh, J., Chiang, J. Y., Chiang, H., Shao, P., Sung, P., & Yip, H. (2024) · World Journal of Stem Cells · doi:10.4252/wjsc.v16.i6.690 · Cited by 3
Adherence to Lung Protective Ventilation in ARDS: A Mixed Methods Study Using Real-Time Continuously Monitored Ventilation Data
Plasek, J. M., Hou, P. C., Zhang, W., Ortega, C. A., Tan, D., Atkinson, B. J., Chuang, Y.-W., Baron, R. M., & Zhou, L. (2024) · Respiratory Care · doi:10.1089/respcare.12183 · Cited by 3
Translational Research in Intensive Care Unit: Novel Approaches for Drug Development and Personalized Medicine
Samanta, R. J., & Summers, C. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1698407 · Cited by 3
Critical Care Considerations in Adult Patients With Influenza-Induced ARDS
Smith, R. E., & Shifrin, M. M. (2020) · Critical Care Nurse · doi:10.4037/ccn2020746 · Cited by 3
Paediatric Acute Respiratory Distress Syndrome Neuromuscular Blockade study (PAN-study): a phase IV randomised controlled trial of early neuromuscular blockade in moderate-to-severe paediatric acute respiratory distress syndrome
Rudolph, M. W., Slager, S., Burgerhof, J. G. M., van Woensel, J. B. M., Alffenaar, J. C., Asperen, R. M. W., de Hoog, M., IJland, M. M., & Kneyber, M. C. J. (2022) · Trials · doi:10.1186/s13063-021-05927-w · Cited by 3
Critical Care Randomized Trials Demonstrate Power Failure: A Low Positive Predictive Value of Findings in the Critical Care Research Field
Nostedt, S., & Joffe, A. R. (2022) · Journal of Intensive Care Medicine · doi:10.1177/08850666221077203 · Cited by 3
Early Prone versus Supine Positioning in Moderate to Severe Coronavirus Disease 2019 Patients with Acute Respiratory Distress Syndrome
Hashim, A. H. A., Al-Zakwani, I. S., Jadidi, A. A., Harthi, R. A., Naabi, M. A., Biyappu, R., Kodange, S., Asati, N. K., Barhi, T. A., Mohan, M., et al. (2022) · Oman Medical Journal · doi:10.5001/omj.2023.52 · Cited by 3
Neuromuscular blockade in mechanically ventilated pneumonia patients with moderate to severe hypoxemia: A multicenter retrospective study
Baek, M. S., Kim, J. H., Lim, Y., & Kwon, Y. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277503 · Cited by 3
Acute Respiratory Distress Syndrome in Pregnancy and Peripartum: Facts and Figures
Shaikh, N., Tharayil, A. G. M., Chanda, A. H., Ganaw, A. E. A., Riaz, M. S., Rohrig, S. A. H., & Lance, M. D. (2020) · Indian Journal of Respiratory Care · doi:10.4103/ijrc.ijrc_34_19 · Cited by 3
The Basics of ARDS Mechanical Ventilatory Care for Cardiovascular Specialists
Rayner‐Hartley, E., Miller, P. E., Burstein, B. J., Bibas, L., Goldfarb, M., Rampersad, P. P., & van Diepen, S. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.07.011 · Cited by 3
Mechanical ventilation in SARS-CoV-2 patients: state of art
Reyes, D. Á., García-Pasichana, B. D., Gutierrez, G. S., Gómez, J. F., Piedrahita, D. R. E., Mejía, J. C. G., & Flórez, M. A. (2021) · Colombian Journal of Anesthesiology · doi:10.5554/22562087.e971 · Cited by 3
ARDS Outcomes in Non-Research Subjects Assessed by Generalized Prospective Trial Eligibility Criteria and Adherence to Lung-Protective Ventilation
Kallet, R. H., Lipnick, M. S., & Pirracchio, R. (2021) · Respiratory Care · doi:10.4187/respcare.09116 · Cited by 3
Extracorporeal life support in adult patients with out-of-hospital cardiac arrest
Lim, J., Chakaramakkil, M. J., & Tan, B. (2021) · Singapore Medical Journal · doi:10.11622/smedj.2021113 · Cited by 3
A Probe into the Intervention Mechanism of Yiqi Huayu Jiedu Decoction on TLR4/NLRP3 Signal Pathway in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome (ARDS) Rats
Ma, Y., Chen, Y., Li, Y., Liu, Y., Kong, Y., Zou, Q., Guo, Z., Li, X., Chu, Y., & Wang, Q. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/3051797 · Cited by 3
Predictors of Cisatracurium Continuous Infusion Dose in Acute Respiratory Distress Syndrome
Merkel, A., Massey, K., Bellamy, C. J., Miano, T. A., Fuchs, B. D., & Candeloro, C. L. (2019) · Journal of Pharmacy Practice · doi:10.1177/0897190019888103 · Cited by 3
Supportive Management and Interventions for Respiratory Failure Due to SARS-CoV-2
Baltaji, S., Ledgerwood, C., Finoli, L. M., Lyons, C., & Cheema, T. J. (2020) · Critical Care Nursing Quarterly · doi:10.1097/cnq.0000000000000322 · Cited by 3
Non-specialist therapeutic strategies in acute respiratory distress syndrome: a meta-analysis
Longobardo, A., Snow, T. A. C., Tam, K., Singer, M., Bellingan, G. J., & Arulkumaran, N. (2021) · Minerva Anestesiologica · doi:10.23736/s0375-9393.21.15254-x · Cited by 3
OLA strategy for ARDS: Its effect on mortality depends on achieved recruitment (PaO2/FiO2) and mechanical power. Systematic review and meta-analysis with meta-regression
Alapont, V. M. I., Villanueva, A. M., Guerra, P. D. V., Camilo, C., Fernández-Ureña, S., Gordo-Vidal, F., & Khemani, R. G. (2021) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2021.03.001 · Cited by 3
Neuromuscular blocking agents as part of lung-protective strategy in severe ARDS patients
Papazian, L., Hraiech, S., Cazenave, L., & Forel, J.-M. (2019) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2019.07.002 · Cited by 3
In defence of extrapolation but not improvisation in SARS-CoV-2 lung disease
Epelbaum, O., & Galperin, I. (2020) · Breathe · doi:10.1183/20734735.0113-2020 · Cited by 3
Anatomical, physiological and clinical similarities and differences in ARDS physiological subtypes
Jha, A. K. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06348-8 · Cited by 3
Treatment Mechanism and Inflammatory Subphenotyping in Acute Respiratory Distress Syndrome
Serra, A. L., Meyer, N. J., & Beitler, J. R. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202402-0340ed · Cited by 3
Mind the gap: understanding the discordance between the ATS and ESICM ARDS guidelines—the ATS perspective
Sahetya, S. K., Rochwerg, B. N., & Fan, E. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07431-6 · Cited by 3
El tratamiento del síndrome de distrés respiratorio agudo
Jover, R. P. B., Lizana, C. V., Ganoza, I. V. M., Álvarez, M. D. M. R., & del Águila, E. O. (2022) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2022.02.006 · Cited by 2
Platelet count as a prognostic marker for acute respiratory distress syndrome
Wang, Q., & Zhang, G. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03204-5 · Cited by 2
FRAIL PARTICIPANTS IN RANDOMIZED CONTROLLED TRIALS OF ACUTE RESPIRATORY DISTRESS SYNDROME
Ntaidou, T. K., Giannakoulis, V. G., Papoutsi, E., Vavouraki, E. A., Theodorou, E., Παπαθανάκος, Γ., Dimopoulou, I., Routsi, C., Kotanidou, A. N., & Siempos, I. Ι. (2025) · Shock · doi:10.1097/shk.0000000000002517 · Cited by 2
The association between non-depolarizing neuromuscular blockade agents and survival to discharge in dogs undergoing mechanical ventilation: a multi-center retrospective study of 227 dogs (2010–2020)
Ngo, L., Walton, R. A. L., Wolf, J. M., Levy, N. A., Ludwik, T. M., Thevelein, B. A. L., Blong, A. E., Cai, J., & Mochel, J. P. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1539138 · Cited by 2
Optimal Sedation in Ventilated Patients with Sepsis and Septic Shock
Marra, A., Smith, R. J., Pandharipande, P. P., & Hayhurst, C. J. (2025) · Critical Care Clinics · doi:10.1016/j.ccc.2025.05.004 · Cited by 2
Prone Positioning to Improve Cerebral Oxygenation in Patients With Acute Respiratory Distress Syndrome
Fédun, Y., Campillo‐Gimenez, B., Delbove, A., Goepp, A., Lebas, E., Sevin, F. D., Mateos, F., Huntzinger, J., Launey, Y., & Reizine, F. (2025) · American Journal of Critical Care · doi:10.4037/ajcc2025879 · Cited by 2
Sedating with volatile anaesthetics for COVID-19 and non-COVID-19 acute hypoxaemic respiratory failure patients in ICU (SAVE-ICU): protocol for a randomised clinical trial
Jerath, A., Slessarev, M., Martin, C. M., D’Aragon, F., Carrier, F. M., Senaratne, J. M., Meggison, H., Hooper, J., Cavayas, Y. A., Goligher, E. C., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-108441 · Cited by 2
Acute Respiratory Distress Syndrome Definitions in Adults and Children: A Comparative Narrative Review
González‐Pizarro, P., & Suárez-Sipmann, F. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14217644 · Cited by 2
Clinical Patterns of Rocuronium and Cisatracurium Use in Acute Respiratory Distress Syndrome: A Retrospective Cohort Study
Khan, I., Hendin, A., Kovacs, B., Seguin, D., Richler, C., Landry, C., & Thabet, P. (2026) · Diseases · doi:10.3390/diseases14010022 · Cited by 2
Advances in Imaging and Physiology-Guided Personalized Care in Acute Respiratory Distress Syndrome
de Moraes, L. R., Silva, P. L., Battaglini, D., & Rocco, P. R. M. (2026) · Medicina · doi:10.3390/medicina62020420 · Cited by 2
Effect of therapeutic interventions combined with lung-protective ventilation on long-term mortality of patients with acute respiratory distress syndrome: a network meta-analysis
Aoyama, H., Uchida, K., Aoyama, K., Yang, A., Pechlivanoglou, P., Englesakis, M. F., Yamada, Y., & Fan, E. (2026) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-026-03069-8 · Cited by 2
Sedation, Analgesia, and Neuromuscular Blockade
Castro, D. M., Carini, F. C., & Fan, E. (2026) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2026.04.003 · Cited by 2
Risk factors of self-extubation in intensive care. Retrospective cohort study
Laverde-Sabogal, C. E., Espinosa‐Almanza, C. J., Patiño-Hernández, D., Rodríguez-Escallón, H., Aguado-Valderrama, J. C., & Lara-Monsalve, P. A. (2022) · Colombian Journal of Anesthesiology · doi:10.5554/22562087.e1050 · Cited by 2
Critical Care Pharmacist Attitudes and Perceptions of Neuromuscular Blocker Infusions in ARDS
Devlin, J. W., Train, S. E., Burns, K. E. A., Massaro, A. F., Wu, T., Castor, T., Vassaur, J., Selvan, K. C., Kress, J. P., & Erstad, B. L. (2023) · Annals of Pharmacotherapy · doi:10.1177/10600280231160437 · Cited by 2
Neuromuscular Blocking Agents in the Intensive Care Unit
Chaves-Cardona, H. E., & Renew, J. R. (2023) · Current anesthesiology reports · doi:10.1007/s40140-023-00577-x · Cited by 2
Comparison of Fixed Dosing vs Train of Four Titration of Cisatracurium in COVID-19 ARDS Patients
Banerjee, O., Elefritz, J. L., Doepker, B. A., Atyia, S. A., Brummel, N. E., Smith, R. M., Handley, D., & Cape, K. M. (2023) · Journal of Pharmacy Practice · doi:10.1177/08971900231220438 · Cited by 2
LIPS and PaO2/FiO2 Combined Plasma Biomarkers Predict Onset of Acute Respiratory Distress Syndrome in Patients of High Risks in SICU: A Prospective Exploratory Study
Shen, Z., Yin, Z., Wei, S., Cong, Z., Zhao, F., Zhang, H., & Zhu, X. (2024) · Mediators of Inflammation · doi:10.1155/2024/4936265 · Cited by 2
Spontaneous breathing-induced lung injury in mechanically ventilated patients
Hoshino, T., & Yoshida, T. (2024) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001231 · Cited by 2
Association Between Rocuronium Administration and Clinical Outcomes in Patients With Moderate-To-Severe Acute Respiratory Distress Syndrome: A Retrospective Cohort Study
Tonai, M., Sasabuchi, Y., Watanabe, H., Matsui, H., & Yasunaga, H. (2025) · Annals of Pharmacotherapy · doi:10.1177/10600280251329195 · Cited by 2
Acute Respiratory Distress Syndrome and Inhaled Sedation—Reply
Jabaudon, M., Futier, E., & Constantin, J. (2025) · JAMA · doi:10.1001/jama.2025.8701 · Cited by 2
Management of Mechanical Ventilation in Emergency Medicine: A Scoping Review
Klemisch, R. J., Hymowitz, M. S., Alcantara, R. J., Mullan, B. F., Davis, M. L., Blume, R., Johnson, N. J., & Fuller, B. M. (2025) · Journal of the American College of Emergency Physicians Open · doi:10.1016/j.acepjo.2025.100297 · Cited by 2
Overview of respiratory care for Covid-19 patients
Refaie, B. M., & Gad, E. M. (2020) · Sohag Medical Journal · doi:10.21608/smj.2020.33248.1168 · Cited by 2
A narrative review of non-pharmacological management of SARS-CoV-2 respiratory failure: a call for an evidence based approach
Vashisht, R., Krishnan, S., & Duggal, A. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-4633 · Cited by 2
Clinical Policies and Procedures for Critical Care Transport during a Respiratory Pandemic
Leisten, D. C., Wheeler, J. A., Boomhower, J., Frakes, M. A., Denison, T., Cohen, J. E., & Wilcox, S. R. (2021) · Prehospital and Disaster Medicine · doi:10.1017/s1049023x21001023 · Cited by 2
Advances in the Pharmacological Management of Pediatric Acute Respiratory Distress Syndrome
Matera, M. G., Imperatore, F., Annibale, R., & Cazzola, M. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.2006632 · Cited by 2
Use of Aerosolized Prostacyclins in Critically Ill Patients and Association With Clinical Outcomes
Hussain, S. T., Jaliawala, H. A., Zhao, D. Y., Ijaz, S. H., Tsui, J., Chasteen, B., Brown, B. R., & Bernardo, R. J. (2023) · Critical Care Explorations · doi:10.1097/cce.0000000000000845 · Cited by 2
Acute Respiratory Distress Syndrome
Chen, L., & Kraft, B. D. (2025) · Springer eBooks · doi:10.1007/978-3-031-77335-8_5 · Cited by 2
Early neuromuscular blockade in acute respiratory distress syndrome: to personalize or paralyze?
Parhar, K. K. S., Solverson, K., & Zochios, V. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.12.101 · Cited by 2
A survey on the practices and capabilities in the management of respiratory failure in South East England
Jha, A., Vasques, F., Sanderson, B., Daly, K., Glover, G. W., Ioannou, N., Wyncoll, D. L. A., Sherren, P. B., Langrish, C., Meadows, C. I. S., et al. (2020) · Journal of the Intensive Care Society · doi:10.1177/1751143720928895 · Cited by 2
Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome
Carlton, E. F., Ice, E., Barbaro, R. P., Kampuis, L., Moss, M., Angus, D. C., Banner‐Goodspeed, V., Ginde, A. A., Gong, M. N., Grissom, C. K., et al. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.04.006 · Cited by 2
Neuromuscular blocking agents for acute respiratory distress syndrome
Kuriyama, A., & Jackson, J. L. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014693 · Cited by 2
Application of Neuromuscular Blockers in Patients with ARDS in ICU: A Retrospective Study Based on the MIMIC-III Database
Pan, X., Liu, J., Zhang, S., Huang, S., Chen, L., Shen, X., & Chen, D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051878 · Cited by 2
Incidence of barotrauma in patients with COVID-19 (alpha- and beta-predominant period) requiring mechanical ventilation: Single-center retrospective study
Donohue, K.-N., Sivanushanthan, S., Etling, E. B., Hockstein, M. J., Yohannes, S., & Clark, P. A. (2023) · SAGE Open Medicine · doi:10.1177/20503121231159479 · Cited by 2
How Electronic Medical Record Integration Can Support More Efficient Critical Care Clinical Trials
Agarwal, A., Marion, J. T., Nagy, P. G., Robinson, M., Walkey, A. J., & Sevransky, J. (2023) · Critical Care Clinics · doi:10.1016/j.ccc.2023.03.006 · Cited by 2
Acute Respiratory Distress Syndrome
Patch, R. K., & Oeckler, R. A. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197628638.003.0019 · Cited by 2
Less is more, but are we doing enough?
Ñamendys-Silva, S. A. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05831-7 · Cited by 2
Community Experience With Acute Respiratory Distress Syndrome in the Prone Position
Khan, F., Fistler, C. R., Mixell, J., Caplan, R. J., & Vest, M. T. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000068 · Cited by 2

Authors: The National Heart, L.
Corresponding author: The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2019-05-23
Volume: 380
Issue: 21
Pages: 1997-2008
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1901686
PMC: PMC6741345
OpenAlex: W2944755457
Cited by: 886
References: 47
Citations by year: 2026: 63 · 2025: 99 · 2024: 90 · 2023: 128 · 2022: 141 · 2021: 146 · 2020: 175 · 2019: 43
FWCI: 92.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nejmgroup.org/legal/terms-of-use.htm (vor)
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (U01HL122989, U01HL122998, U01HL123004, U01HL123008, U01HL123009, U01HL123010, U01HL123018, U01HL123020, U01HL123022, U01HL123023, U01HL123027, U01HL123031, U01HL123033)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: acute respiratory distress syndrome, neuromuscular blockade, cisatracurium, mechanical ventilation, positive end-expiratory pressure, sedation, mortality, futility
MeSH terms: Adult, Aged, Atracurium, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Neuromuscular Blocking Agents, Positive-Pressure Respiration, Respiratory Distress Syndrome, Conscious Sedation, Procedural Sedation, Hospital Mortality, Treatment Failure, Neuromuscular Blockade

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks