Cited by 890Respiratory Support and MechanismsAnesthesia and Sedative AgentsIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

Open access

The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network·2019·New England Journal of Medicine

DOI 10.1056/nejmoa1901686PMC PMC6741345

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear. METHODS: We randomly assigned patients with moderate-to-severe ARDS (defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure [PEEP] of ≥8 cm of water) to a 48-hour continuous infusion of cisatracurium with concomitant deep sedation (intervention group) or to a usual-care approach without routine neuromuscular blockade and with lighter sedation targets (control group). The same mechanical-ventilation strategies were used in both groups, including a strategy involving a high PEEP. The primary end point was in-hospital death from any cause at 90 days. RESULTS: The trial was stopped at the second interim analysis for futility. We enrolled 1006 patients early after the onset of moderate-to-severe ARDS (median, 7.6 hours after onset). During the first 48 hours after randomization, 488 of the 501 patients (97.4%) in the intervention group started a continuous infusion of cisatracurium (median duration of infusion, 47.8 hours; median dose, 1807 mg), and 86 of the 505 patients (17.0%) in the control group received a neuromuscular blocking agent (median dose, 38 mg). At 90 days, 213 patients (42.5%) in the intervention group and 216 (42.8%) in the control group had died before hospital discharge (between-group difference, -0.3 percentage points; 95% confidence interval, -6.4 to 5.9; P = 0.93). While in the hospital, patients in the intervention group were less physically active and had more adverse cardiovascular events than patients in the control group. There were no consistent between-group differences in end points assessed at 3, 6, and 12 months. CONCLUSIONS: Among patients with moderate-to-severe ARDS who were treated with a strategy involving a high PEEP, there was no significant difference in mortality at 90 days between patients who received an early and continuous cisatracurium infusion and those who were treated with a usual-care approach with lighter sedation targets. (Funded by the National Heart, Lung, and Blood Institute; ROSE ClinicalTrials.gov number, NCT02509078.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1901686

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)
Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., Bonsel, G., & Badia, X. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9903-x · Cited by 9,795
Acute Respiratory Distress Syndrome
Ards Definition Task Force (2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 9,066
Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries.
Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766
Identification of Causal Effects Using Instrumental Variables
Angrist, J. D., Imbens, G. W., & Rubin, D. B. (1996) · Journal of the American Statistical Association · doi:10.1080/01621459.1996.10476902 · Cited by 4,230
Prone positioning in severe acute respiratory distress syndrome.
Guérin, C., Reignier, J., Richard, J.-C., Beuret, P., Gacouin, A., Boulain, T., Mercier, E., Badet, M., Mercat, A., Baudin, O., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214103 · Cited by 4,040
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
Barr, J., Fraser, G. L., Puntillo, K., Ely, E. W., Gélinas, C., Dasta, J. F., Davidson, J. E., Devlin, J. W., Kress, J. P., Joffe, A. M., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182783b72 · Cited by 3,896

Flagged first, then by citations

Show all 47 references

Sorted by citations

Items 601–700 of 890

Patient and Care Delivery Characteristics Associated With Harm From Neuromuscular Blockade
Poole, B. R., Reese, Z. A., Dechen, T., Tocci, N. X., Elsamadisi, P., Holland, S., Hayes, M. M., & Stevens, J. P. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000147 · Cited by 2
Mechanical Ventilation and Coronavirus Disease 2019: A Case-Control Analysis of Clinical Characteristics, Lung Mechanics, and Mortality
Sayf, A. A., Fadel, R. A., Scott, A., BIZRI, L. A., Kong, W. T., Rezik, M., Joyce, K. M., Alalwan, Y., Dabaja, M. K., Nair, S. N., et al. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000377 · Cited by 2
Oxygen Therapy in the ICU
Das, S. K., Choupoo, N. S., & Ray, S. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2009489 · Cited by 2
Can Acute Respiratory Distress Syndrome Be Treated?
Christman, J. W., Karpurapu, M., & Pei, D. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0014 · Cited by 2
Discussions on VT4COVID – Authors' reply
Richard, J., Rabilloud, M., Abbas‐Chorfa, F., & Bitker, L. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00344-2 · Cited by 2
Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help?
Torres, L. K., & Siempos, I. Ι. (2024) · Thorax · doi:10.1136/thorax-2023-221131 · Cited by 2
Safety and Effectiveness of Neuromuscular Blockers in the Treatment of Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis
Aisa-Álvarez, A., Rojas-Gomez, C. A., & Camarena-Alejo, G. (2020) · International Journal of Critical Care and Emergency Medicine · doi:10.23937/2474-3674/1510098 · Cited by 1
Revisiting Old Friends: Adjunctive Therapies in Acute Respiratory Distress Syndrome
Gao, C. A., Mylvaganam, R. J., Poor, T. A., & Walter, J. M. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202009-3722rr · Cited by 1
Treatment of critically ill COVID-19 patients: Practical guidelines
Stevanovic, P. D. (2021) · Medicinski podmladak · doi:10.5937/mp72-33371 · Cited by 1
Pulmonary
Madisi, N. Y., & Abouzgheib, W. B. (2021) · Springer eBooks · doi:10.1007/978-3-030-67123-5_23 · Cited by 1
Supportive Care in Patients with Critical Coronavirus Disease 2019
Sweeney, D. A., & Malhotra, A. (2022) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2022.08.003 · Cited by 1
Intensivmedizin
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_13 · Cited by 1
Airway Versus Transpulmonary Driving Pressures During Pressure Support Ventilation in ARDS
Zheng, C. Z., & Cortes-Puentes, G. A. (2023) · Respiratory Care · doi:10.4187/respcare.11428 · Cited by 1
Protocol for fever control using external cooling in mechanically ventilated patients with septic shock: SEPSISCOOL II randomised controlled trial
Arnoux, A., Murris, J., Béchet, S., Jung, C., Auchabie, J., Dupeyrat, J., Anguel, N., Asfar, P., Badie, J. C., Carpentier, D., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2022-069430 · Cited by 2
Neuromuscular Blockade in Adult Respiratory Distress Syndrome
Burns, K. E. A., & Myatra, S. N. (2024) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2024.08.008 · Cited by 1
MEGA: a computational framework to simulate the acute respiratory distress syndrome
Bruna-Rosso, C., & Boussen, S. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00741.2024 · Cited by 1
Pain and Sedation: Assessment, Prevention, and Treatment in the Intensive Care Unit
Stollings, J. L., & Watkins, S. E. (2025) · Springer eBooks · doi:10.1007/978-3-031-77335-8_46 · Cited by 1
Approach to mechanical ventilation: a simplified approach for a pulmonologist
Upadhya, P., Sanjana, H. S., Harshith, R., Vemuri, M. B., Balasoupramaniane, K., & Nadaf, Z. (2025) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2025.3476 · Cited by 1
Exploring pharmacological strategies in the management of ARDS: Efficacy, limitations, and future directions
Almuntashiri, S. (2025) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2025-0030 · Cited by 1
Optimal Sedation During Severe Acute Respiratory Distress Syndrome
Nassar, A. P., Veiga, V. C., & Serafim, R. B. (2025) · Critical Care Clinics · doi:10.1016/j.ccc.2025.07.004 · Cited by 1
Impact of proning with and without inhaled pulmonary vasodilators and neuromuscular blocking agents in COVID acute respiratory distress syndrome
Cabrera, M., Bharil, S., Chin, M. K., Yohannes, S., & Clark, P. A. (2025) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v14.i3.101327 · Cited by 1
Comparison of Continuous Neuromuscular Blocking Agent Titration Strategies in Acute Respiratory Distress Syndrome
Maier, A., Kolar, R., Shible, A. A., Roberts, O., Westlake, E., Merritt, T., Hauser, P., Hung, J., & Collier, T. E. (2025) · Annals of Pharmacotherapy · doi:10.1177/10600280251388441 · Cited by 1
Recognizing and managing excessive respiratory drive and effort: an expert narrative review
Pacchiarini, G., Monteleone, F., Zarantonello, F., Sella, N., Bassi, M., Zambianchi, A., Fincati, V., Bolzon, A., Pistollato, E., CASSAI, A. D., et al. (2026) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2026.2622110 · Cited by 1
Comparison of Train-of-Four Versus No Train-of-Four Monitoring of Neuromuscular Blockade on Drug Consumption for Acute Respiratory Distress Syndrome
Yaeger, K. N., Rivosecchi, R. M., Clarkson, J., Lamberty, P. E., & Groetzinger, L. M. (2026) · Annals of Pharmacotherapy · doi:10.1177/10600280251414669 · Cited by 1
AI-enabled advances and future directions in lung injury: toward earlier recognition, mechanistic phenotyping, and precision supportive care
Liang, Q., Yang, C., & Bai, C. (2026) · Clinical eHealth · doi:10.1016/j.ceh.2026.03.002 · Cited by 1
Inherent safety risks of guidelines derived from “cause-agnostic” randomized controlled trials: a review
Lynn, L. (2026) · Patient Safety in Surgery · doi:10.1186/s13037-026-00486-y · Cited by 1
Decades of intensive care medicine trials: what randomised evidence has changed, corrected, and still questions to resolve
Martín‐Loeches, I., Léone, M., Coopersmith, C. M., Machado, F. R., Hodgson, C. L., Calfee, C. S., & Schultz, M. J. (2026) · Intensive Care Medicine · doi:10.1007/s00134-026-08579-z · Cited by 1
Spezifische Therapie des akuten Lungenversagens
Wrigge, H., & Glien, C. (2020) · Der Anaesthesist · doi:10.1007/s00101-020-00844-0 · Cited by 1
PNEUMOMEDIASTINO ESPONTÂNEO POR CETOACIDOSE DIABÉTICA
Mattar, B. A., Tabushi, F. I., Mattar, C. A., MATTAR, D. A., Cardoso, C. E. D. P., NIGRO, M. V. D. A. S., Mauer, S., & SPOSITO, V. (2022) · REVISTA MÉDICA DO PARANÁ · doi:10.55684/79.2.1677 · Cited by 1
Akutes Lungenversagen (ARDS)
Kluge, S., & Sieweke, A. (2023) · Springer Reference Medizin · doi:10.1007/978-3-642-54676-1_357-2 · Cited by 1
Use of Extracorporeal Membrane Oxygenation for Patients with Coronavirus Disease 2019 Infection
Ruck, J. M., & Bush, E. L. (2024) · Advances in Surgery · doi:10.1016/j.yasu.2024.05.003 · Cited by 1
Efficacy and safety of several common drugs in the treatment of acute respiratory distress syndrome: A systematic review and network meta-analysis
Liu, Q., Xiang, G.-H., Liu, W., Dong, J., Wen, Y., & Hao, H. (2024) · Medicine · doi:10.1097/md.0000000000040472 · Cited by 1
Protective effects of minocycline, a tetracycline antibiotic, on cytokine storm and oxidative stress in acute lung injury
Yin, W., Wen, B., Xiao, Y., Ou, X., Rong, C., Wan, L., Wu, W., & Yu, P. Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114975 · Cited by 1
Patient self-inflicted lung injury – does it really exist?
Jubran, A., Laghi, F. A., & Tobin, M. J. (2025) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001354 · Cited by 1
Flawed design and selection bias in critical care randomized controlled trials (RCTs): the patient safety risk of the “RCT mimic”
Lynn, L. A. (2025) · Patient Safety in Surgery · doi:10.1186/s13037-025-00456-w · Cited by 1
Utilization of Neuromuscular Blocking Agents in Acute Brain Injury and Associations with Outcomes: A Post Hoc Analysis of the ENIO Study
Berardino, A., Gallo, F., Battaglini, D., Cinotti, R., Asehnoune, K., Rocco, P. R. M., Taccone, F. S., Patroniti, N. A., Schultz, M. J., Barbanera, A., et al. (2026) · Neurocritical Care · doi:10.1007/s12028-026-02473-8 · Cited by 1
Prone positioning in ARDS
Ehrmann, S., Li, J., Liu, L., & Guérin, C. (2026) · Intensive Care Medicine · doi:10.1007/s00134-026-08543-x · Cited by 1
The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies
Tan, D., Zhou, J., Li, L., Zhong, Y., Cheng, Z., & Yang, T. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00532-2 · Cited by 1
Mechanical Ventilation And Extracorporeal Membrane Oxygenation Considerations In COVID-19
Sinha, A., Deshwal, H., & Vashisht, R. (2021) · Cited by 1
Extracorporeal Membrane Oxygenation Support Therapy
Loforte, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101000 · Cited by 1
Advancing Sedation Strategies to Improve Clinical Outcomes in Ventilated Critically Ill Patients
Shehabi, Y., Al‐Bassam, W., & Antognini, D. (2023) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-031-23005-9_17 · Cited by 1
Alveolar Hemorrhage
Wakwaya, Y. T., & Frankel, S. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-12950-6_9 · Cited by 1
Updated Guidelines for Acute Respiratory Distress Syndrome
Kim, T. W., & Kim, W. (2023) · Korean Journal of Medicine · doi:10.3904/kjm.2023.98.5.212 · Cited by 1
Therapeutic effect of cisatracurium in patients with acute respiratory distress syndrome
Li, Y., Li, J., & Ni, Z. (2023) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v22i10.19 · Cited by 1
The impact of aggressive and conservative propensity for initiation of neuromuscular blockade in mechanically ventilated patients with hypoxemic respiratory failure
Shahn, Z., Jung, B., Talmor, D. S., Kennedy, E. H., Lehman, L.-W. H., & Kassis, E. B. (2024) · Journal of Critical Care · doi:10.1016/j.jcrc.2024.154803 · Cited by 1
Early pathophysiology-driven airway pressure release ventilation versus low tidal volume ventilation strategy for patients with moderate-severe ARDS: study protocol for a randomized, multicenter, controlled trial
Zhou, Y., Cheng, J., Zhu, S., Dong, M., Lv, Y., Jing, X., & Kang, Y. M. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03065-y · Cited by 1
Reflections on a Respiratory Therapy Postgraduate Certificate Program in Chile
Kattan, E., Basoalto, R., Retamal, J., Oviedo, V., Bruhn, A. R., & Bugedo, G. J. (2024) · ATS Scholar · doi:10.34197/ats-scholar.2024-0025ps · Cited by 1
Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease
Palomo, J. J., Martín‐Conty, J. L., López, B. P., Picón, C. R., López‐Izquierdo, R., Vegas, C. D. P., Castro, P. Á. D. S., García, A. S., & Rodríguez, F. M. (2024) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2025.008 · Cited by 1
The TyG index correlation with invasive ventilator in critically ill patients: A retrospective analysis of the MIMIC-IV database
Hu, J., Min, J., & Zong, D. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.03.009 · Cited by 1
Current Standards and Practices in Small Animal Mechanical Ventilation
Balakrishnan, A. (2025) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2025.02.003 · Cited by 2
The brain: an overloaded but overlooked organ. Author’s reply
Mongodi, S., Aguilera, J., Mercado, P., Adrião, D., & Camporota, L. (2025) · Intensive Care Medicine · doi:10.1007/s00134-025-07953-7 · Cited by 1
Emergency medicine updates: Acute respiratory distress Syndrome
Long, B., Lentz, S. A., & Gottlieb, M. A. (2025) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2025.06.066 · Cited by 1
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury
Pickering, H. C., Alipanah, N., Chen, E., Duchen, D., Maecker, H. T., Kim‐Schulze, S., Montgomery, R. R., Cotsapas, C. J., Steen, H., Krammer, F., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.191951 · Cited by 1
Prognostic impact of angiotensin-converting enzyme inhibitors and dexmedetomidine in acute respiratory distress syndrome: a MIMIC-IV-based retrospective cohort analysis
Hong, Q., Yang, X., Yang, H., Zhou, X., Tang, J., & Wen, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1601565 · Cited by 1
Precision in Mechanical Ventilation
Dugan, K. C., & Patel, B. K. (2020) · Respiratory medicine · doi:10.1007/978-3-030-31507-8_23 · Cited by 1
ERS International Congress, Madrid, 2019: highlights from the Respiratory Intensive Care Assembly
Satıcı, C., Padilla, D. E. L., Schreiber, A. F., Kharat, A., Swingwood, E. L., Pisani, L., Patout, M., Bos, L. D. J., Scala, R., Schultz, M. J., et al. (2020) · ERJ Open Research · doi:10.1183/23120541.00331-2019 · Cited by 2
Extracorporeal Circulation in Acute Respiratory Failure: High Flow Versus Low Flow
Caccioppola, A., Galanti, V., Froio, S., Coppola, S., & Chiumello, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-43873-9_5 · Cited by 1
Diagnostic et traitement du syndrome de détresse respiratoire aiguë
Fernando, S. M., Ferreyro, B. L., Urner, M., Munshi, L., & Fan, E. (2021) · Canadian Medical Association Journal · doi:10.1503/cmaj.202661-f · Cited by 5
Cisatracurium Dosing Requirements in COVID-19 Compared to Non-COVID-19 Patients
Ingebrigtson, M., Farina, N., Miller, J. T., Renius, K., McSparron, J. I., & Kenes, M. T. (2021) · Journal of Pharmacy Practice · doi:10.1177/08971900211052835 · Cited by 1
Inpatient Management and OBICU Care for Pregnant Patients With Severe COVID-19 Disease
Vaught, A. “. J. (2021) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000683 · Cited by 1
Continuously protracted infusion of cisatracurium besilate in patients with ARDS
Yuan, Z., Pan, L., Wang, Y., & Wang, W. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.103718 · Cited by 1
Mechanical Ventilation During Patient’s Transferral
Wilcox, S. R., & Che, R. (2022) · Springer eBooks · doi:10.1007/978-3-030-93401-9_28 · Cited by 1
Control of Breathing
Moya, E. A., Simonson, T. S., Powell, F. L., Owens, R. L., & Malhotra, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-73387-2_15 · Cited by 1
Management of Acute Respiratory Distress Syndrome
Hyzy, R. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-26710-0_21 · Cited by 1
What Works in a Patient With Acute Respiratory Distress Syndrome?
Steinhorn, R., & Fitzsimons, M. G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-77846-6.00055-0 · Cited by 1
Sedation and Neuromuscular Blockade in Oncology Critical Care
Keady, T., & Narayanan, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-9929-0_8 · Cited by 1
The Utility of ECMO in Acute Respiratory Distress Syndrome
Binder, A. K., & Singla, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106603 · Cited by 1
Prognostic value of the novel P/FPE index to classify ARDS severity: A cohort study
Martos-Benítez, F. D., Muguercia, R. E., Orama-Requejo, V., & del Toro-Simoni, T. (2022) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2022.06.023 · Cited by 1
Techniques for Oxygenation and Ventilation in Coronavirus Disease 2019
Richards, G. A., & Smith, O. (2023) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0042-1758836 · Cited by 1
Management of acute respiratory failure
Vasques, F., Slattery, M., Srivastava, S. A., & Camporota, L. (2023) · Medicine · doi:10.1016/j.mpmed.2023.08.009 · Cited by 1
Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ): An observational study
Parke, R. L., McGuinness, S., Cavadino, A., Cowdrey, K.-A., Bates, S., Bihari, S., Corley, A., Gilder, E., Hodgson, C. L., Litton, E., et al. (2024) · Critical Care and Resuscitation · doi:10.1016/j.ccrj.2024.05.001 · Cited by 1
Probability of benefit with the use of neuromuscular blockade in patients with acute respiratory distress syndrome
de Souza, G. M., Vianna, F. S. L., Midega, T. D., & Neto, A. S. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.09.26 · Cited by 1
Interventions to Decrease Mortality Among Patients with Acute Respiratory Distress SyndromePreprint
Cohn, E. (2021) · doi:10.28971/532021ce100 · Cited by 1
Mechanical Ventilation
Yehya, N. (2022) · Springer eBooks · doi:10.1007/978-3-031-07524-7_15 · Cited by 1
Reply to Liufu et al. and to Palanidurai et al.
Matthay, M. A., Ware, L. B., Riviello, E. D., Wick, K. D., Thompson, B., & Martin, T. R. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202402-0284le · Cited by 1
From Detection to Understanding: Sedation Practices as a Mechanism for Disparities in Patients Receiving Mechanical Ventilation
Day, G. L., & Mehta, A. (2024) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202401-121ed · Cited by 1
Application of new ARDS guidelines at the bedside
Diniz-Silva, F., Neto, A. S., & Ferreira, J. C. (2025) · Critical Care Science · doi:10.62675/2965-2774.20250171 · Cited by 1
Specific Circumstances: Acute Respiratory Distress Syndrome (ARDS)
Wilcox, S. R., Aydin, A., & Marcolini, E. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-98410-0_8
Over-EXTENDing the Window for Thrombolytic Therapy in Cerebrovascular Accident
Spiegel, R. J., Donnelly, J. P., & Radecki, R. P. (2019) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2019.07.010
Les curares dans la prise en charge du SDRA : à intégrer dans une stratégie de ventilation protectrice
Papazian, L., Hraiech, S., Cazenave, L., & Forel, J.-M. (2019) · Anesthésie & Réanimation · doi:10.1016/j.anrea.2019.07.003
Insuffisance respiratoire aiguë sévère: actualités thérapeutiques
Girault, C. (2019) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(19)30051-5
Partially supported modes
Putensen, C., & Muenster, S. (2019) · doi:10.1183/9781849841221.028418
Bloqueadores neuromusculares en el síndrome de insuficiencia respiratoria progresiva aguda: metaanálisis
Álvarez, A. A., & Gómez, C. A. R. (2019) · Medicina Crítica · doi:10.35366/91603
Respiração espontânea durante ventilação mecânica em modelo experimental suíno de lesão pulmonar aguda: avaliação da inflamação pulmonar por PET-CT usando dois valores de pressão positiva ao final da expiração
Morais, C. C. A. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-13012020-111219
The choice of optimal modern muscle relaxants (rocuronium bromide, atracurium besilate and cisatracurius besilate) in one-day surgery in children
Nasibova, E. M. (2020) · International Journal of Clinical Anesthesia and Research · doi:10.29328/journal.ijcar.1001014
Ventilační podpora pacientů s COVID-19
Dostál, P. (2020) · Anesteziologie a intenzivní medicína · doi:10.36290/aim.2020.027
Fokus allgemeine Intensivmedizin
Dietrich, M., Beynon, C., Fiedler, M. O., Bernhard, M., Hecker, A., Jungk, C., Nußhag, C., Michalski, D., Brenner, T., Weigand, M. A., et al. (2020) · Der Anaesthesist · doi:10.1007/s00101-020-00857-9
Fokus Beatmung, Sauerstofftherapie und Weaning
Fiedler, M. O., Reuß, C. J., Bernhard, M. H., Beynon, C., Hecker, A., Jungk, C., Nußhag, C., Michalski, D., Brenner, T., Weigand, M. A., et al. (2020) · Der Anaesthesist · doi:10.1007/s00101-020-00859-7
Neuromuscular Blockade for the Critically Ill Child
Ruth, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-52555-2_12
Manejo del paciente grave y crítico
Oropeza, O. G., Martínez, D. M., Iñiguez-García, M. A., Morales, M. S. L., Colín, E. R. G., Rodríguez, R. D. R., García, A. A., García, E. O., Valadez, M. A. F., & Rodríguez, E. G. S. (2020) · Revista Latinoamericana de Infectología Pediátrica · doi:10.35366/96671
Ards and its underlying pathogenesis in N-COV disease
Priyaa, N. P., & Girija, A. S. S. (2020) · European Journal of Molecular & Clinical Medicine
Important publications in intensive care in 2018/2019
Šrámek, V., Čundrle, I., Suk, P., Helán, M., & Hruda, J. (2020) · Anesteziologie a intenzivní medicína · doi:10.36290/aim.2019.074
Early neuromuscular blockade for acute respiratory distress syndrome: a systematic review with meta-analysis and trial sequential analysisPreprint
Zhang, X., Liu, D., Fei-fei, G., Xu, X., & Guan, X. (2020) · doi:10.21203/rs.3.rs-31867/v1
Mortality Associated With Acute Respiratory Distress Syndrome 2009-2019: A Systematic Review and Meta-regressionPreprint
Sadana, D., Kaur, S., Sankaramangalam, K. P., Banerjee, K., Siuba, M., Amaral, V., Gadre, S. K., Torbic, H., Krishnan, S., & Duggal, A. (2020) · doi:10.21203/rs.3.rs-99742/v1
Medidas de protección alveolar en pacientes con COVID-19
García-Salas, Y., Muñoz, B. C., Larios, F. O., & Adalid, J. D. T. (2020) · Medicina Crítica · doi:10.35366/98164
Part I: Anesthesia and ventilator management in critical care patients
Patel, M. K., & Muir, J. (2021) · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · doi:10.1002/jac5.1402
Neuromuscular Blocking Agent Use in Acute Respiratory Distress Syndrome: Which Variable is Important?
Rahimi-Bashar, F., Salesi, M., Vahedian‐Azimi, A., & Fetrat, M. K. (2021) · Hospital Practices and Research · doi:10.34172/hpr.2021.22
Sedation and Neuromuscular Blockade in Acute Respiratory Distress Syndrome: A Step Toward Disentangling Best Practices*
Jabaley, C. S. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005002
Fokus Beatmung, Sauerstofftherapie und Weaning 2021/2022
Fiedler, M. O., Dietrich, M., Reuß, C. J., Bernhard, M. H., Beynon, C., Hecker, A., Jungk, C., Nußhag, C., Michalski, D., Weigand, M. A., et al. (2023) · Die Anaesthesiologie · doi:10.1007/s00101-023-01250-y
Desafíos en el manejo de la sedación, analgesia y bloqueo neuromuscular en el paciente crítico COVID-19 en Chile
Muñoz, D. L., Grandjean, J., Olivares, F., León, P., & Álvarez, I. (2021) · Revista médica de Chile · doi:10.4067/s0034-98872021000400559

Authors: The National Heart, L.
Corresponding author: The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2019-05-23
Volume: 380
Issue: 21
Pages: 1997-2008
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1901686
PMC: PMC6741345
OpenAlex: W2944755457
Cited by: 886
References: 47
Citations by year: 2026: 63 · 2025: 99 · 2024: 90 · 2023: 128 · 2022: 141 · 2021: 146 · 2020: 175 · 2019: 43
FWCI: 92.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nejmgroup.org/legal/terms-of-use.htm (vor)
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (U01HL122989, U01HL122998, U01HL123004, U01HL123008, U01HL123009, U01HL123010, U01HL123018, U01HL123020, U01HL123022, U01HL123023, U01HL123027, U01HL123031, U01HL123033)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: acute respiratory distress syndrome, neuromuscular blockade, cisatracurium, mechanical ventilation, positive end-expiratory pressure, sedation, mortality, futility
MeSH terms: Adult, Aged, Atracurium, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Neuromuscular Blocking Agents, Positive-Pressure Respiration, Respiratory Distress Syndrome, Conscious Sedation, Procedural Sedation, Hospital Mortality, Treatment Failure, Neuromuscular Blockade

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks