Cited by 2,217CAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses

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Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

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Liu, Enli, Marin, David, Banerjee, Pinaki, Macapinlac, Homer A., Thompson, Philip, Basar, Rafet, Nassif Kerbauy, Lucila, Overman, Bethany, Thall, Peter, Kaplan, Mecit, Nandivada, Vandana, Kaur, Indresh, Nunez Cortes, Ana, Cao, Kai, Daher, May, Hosing, Chitra, Cohen, Evan N., Kebriaei, Partow, Mehta, Rohtesh, Neelapu, Sattva, Nieto, Yago, Wang, Michael, Wierda, William, Keating, Michael, Champlin, Richard, Shpall, Elizabeth J., Rezvani, Katayoun·2020·New England Journal of Medicine

DOI 10.1056/nejmoa1910607PMC PMC7101242

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Abstract

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex. Natural killer (NK) cells that have been modified to express an anti-CD19 CAR have the potential to overcome these limitations. METHODS: CAR-NK cells per kilogram of body weight) after lymphodepleting chemotherapy. RESULTS: The administration of CAR-NK cells was not associated with the development of cytokine release syndrome, neurotoxicity, or graft-versus-host disease, and there was no increase in the levels of inflammatory cytokines, including interleukin-6, over baseline. The maximum tolerated dose was not reached. Of the 11 patients who were treated, 8 (73%) had a response; of these patients, 7 (4 with lymphoma and 3 with CLL) had a complete remission, and 1 had remission of the Richter's transformation component but had persistent CLL. Responses were rapid and seen within 30 days after infusion at all dose levels. The infused CAR-NK cells expanded and persisted at low levels for at least 12 months. CONCLUSIONS: Among 11 patients with relapsed or refractory CD19-positive cancers, a majority had a response to treatment with CAR-NK cells without the development of major toxic effects. (Funded by the M.D. Anderson Cancer Center CLL and Lymphoma Moonshot and the National Institutes of Health; ClinicalTrials.gov number, NCT03056339.).

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Maude, S. L., Frey, N., Shaw, P. A., Aplenc, R., Barrett, D. M., Bunin, N. J., Chew, A., Gonzalez, V. E., Zheng, Z., Lacey, S. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407222 · Cited by 5,413
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Park, J. H., Rivière, I., Gonen, M., Wang, X., Sénéchal, B., Curran, K. J., Sauter, C., Wang, Y., Santomasso, B., Mead, E., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709919 · Cited by 2,688
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Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
Miller, J. S., Soignier, Y., Panoskaltsis‐Mortari, A., McNearney, S. A., Yun, G. H., Fautsch, S. K., McKenna, D. H., Le, C. T., DeFor, T. E., Burns, L. J., et al. (2005) · Blood · doi:10.1182/blood-2004-07-2974 · Cited by 1,894

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Cytokine storm
Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196
Exploring the NK cell platform for cancer immunotherapy
Myers, J. A., & Miller, J. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0426-7 · Cited by 1,320
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
Morris, E. C., Neelapu, S. S., Giavridis, T., & Sadelain, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00547-6 · Cited by 1,187
Self-citation
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
Dhatchinamoorthy, K., Colbert, J. D., & Rock, K. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636568 · Cited by 1,077
Natural killer cells in cancer biology and therapy
Wu, S.-Y., Fu, T., Jiang, Y.-Z., & Shao, Z.-M. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01238-x · Cited by 863
Recent advances and discoveries in the mechanisms and functions of CAR T cells
Larson, R. C., & Maus, M. V. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00323-z · Cited by 852
CAR-NK cells: A promising cellular immunotherapy for cancer
Xie, G., Dong, H., Liang, Y., Ham, J. D., Rizwan, R., & Chen, J. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102975 · Cited by 800
Natural killer cells in antitumour adoptive cell immunotherapy
Laskowski, T. J., Biederstädt, A., & Rezvani, K. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00491-0 · Cited by 810
Self-citation
Macrophage-Based Approaches for Cancer Immunotherapy
Anderson, N. R., Minutolo, N. G., Gill, S., & Klichinsky, M. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2990 · Cited by 698
NK cell-based cancer immunotherapy: from basic biology to clinical development
Liu, S., Galat, V., Galat4, Y., Lee, Y. K. A., Wainwright, D., & Wu, J. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01014-w · Cited by 689
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 762
CAR immune cells: design principles, resistance and the next generation
Labanieh, L., & Mackall, C. L. (2023) · Nature · doi:10.1038/s41586-023-05707-3 · Cited by 695
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
Pan, K., Farrukh, H., Chittepu, V. C. S. R., Xu, H., Pan, C.-X., & Zhu, Z. G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02327-z · Cited by 685
Engineering CAR-T Cells for Next-Generation Cancer Therapy
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.005 · Cited by 659
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
Makni‐Maalej, K., Merhi, M., Inchakalody, V. P., Mestiri, S., Alam, M. A., Maccalli, C., Cherif, H., Shahab Uddin, M. S., Steinhoff, M. S., Marincola, F. M., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01723-z · Cited by 662
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
Spiegel, J. Y., Patel, S., Muffly, L. S., Hossain, N. M., Oak, J. S., Baird, J. H., Frank, M. J., Shiraz, P., Sahaf, B., Craig, J. K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01436-0 · Cited by 640
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Wolf, N. K., Kissiov, D. U., & Raulet, D. H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00732-1 · Cited by 622
The cancer–natural killer cell immunity cycle
Huntington, N. D., Cursons, J., & Rautela, J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0272-z · Cited by 595
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
Marín, D., Li, Y., Başar, R., Rafei, H., Daher, M., Dou, J., Mohanty, V., Dede, M., Nieto, Y. L., Uprety, N., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02785-8 · Cited by 567
Self-citation
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Bald, T., Krummel, M. F., Smyth, M. J., & Barry, K. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0728-z · Cited by 523
Cancer immunotherapies: advances and bottlenecks
Rui, R., Zhou, L., & He, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1212476 · Cited by 484
Natural killer cell therapies
Vivier, É., Rebuffet, L., Narni-Mancinelli, É., Cornen, S., Igarashi, R., & Fantin, V. R. (2024) · Nature · doi:10.1038/s41586-023-06945-1 · Cited by 496
From bench to bedside: the history and progress of CAR T cell therapy
Mitra, A., Barua, A., Huang, L., Ganguly, S., Feng, Q. F., & He, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1188049 · Cited by 526
Targeting cytokine and chemokine signaling pathways for cancer therapy
Yi, M., Li, T., Niu, M., Zhang, H., Wu, Y., Wu, K., & Dai, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01868-3 · Cited by 528
The Emerging Landscape of Immune Cell Therapies
Weber, E. W., Maus, M. V., & Mackall, C. L. (2020) · Cell · doi:10.1016/j.cell.2020.03.001 · Cited by 451
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects
Karki, R., & Kanneganti, T. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.001 · Cited by 464
Engineering the next generation of cell-based therapeutics
Bashor, C. J., Hilton, I. B., Bandukwala, H. S., Smith, D. M., & Omid Veiseh, A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00476-6 · Cited by 472
CAR T-cell therapy in autoimmune diseases
Schett, G. A., Mackensen, A., & Mougiakakos, D. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01126-1 · Cited by 449
Recent advances in CAR-T cell engineering
Huang, R., Li, X., He, Y., Zhu, W., Gao, L., Liu, Y. Z., Gao, L., Qin, W., Zhong, J. F., Zhang, C., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00910-5 · Cited by 412
CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges
Zhang, X., Zhu, L., Zhang, H., Chen, S., & Xiao, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.927153 · Cited by 460
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
Peng, L., Sferruzza, G., Yang, L., Zhou, L., & Chen, S. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01207-0 · Cited by 443
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tiwari, A., Trivedi, R., & Lin, S. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00866-3 · Cited by 399
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Gong, Y., Klein Wolterink, R. G. J., Wang, J., Bos, G. M. J., & Germeraad, W. T. V. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01083-5 · Cited by 379
The emerging field of oncolytic virus-based cancer immunotherapy
Ma, R., Li, Z., Chiocca, E. A., Caligiuri, M. A., & Yu, J. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.10.003 · Cited by 339
The interaction of innate immune and adaptive immune system
Wang, R., Lan, C., Benlagha, K., Câmara, N. O. S., Miller, H. E., Kubo, M., Heegaard, S., Lee, P. P. W., Yang, L., Forsman, H. F., et al. (2024) · MedComm · doi:10.1002/mco2.714 · Cited by 395
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
Polak, R., Zhang, E., & Kuo, C. J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00706-6 · Cited by 347
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment
Poznanski, S. M., Singh, K., Ritchie, T. M., Aguiar, J. A., Fan, I. Y., Portillo, A. L., Rojas, E. A. P., Vahedi, F., El‐Sayes, A., Xing, S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.023 · Cited by 309
Immunogenicity of CAR T cells in cancer therapy
Wagner, D. L., Fritsche, E., Pulsipher, M. A., Ahmed, N. M., Hamieh, M., Hegde, M. G., Ruella, M., Savoldo, B., Shah, N. N., Turtle, C. J., et al. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00476-2 · Cited by 318
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells
Daher, M., Başar, R., Gokdemir, E., Baran, N., Uprety, N., Cortes, A. K. N., Mendt, M. C., Kerbauy, L. N., Banerjee, P. P., Shanley, M., et al. (2020) · Blood · doi:10.1182/blood.2020007748 · Cited by 314
Self-citation
Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy
Chen, C., Jing, W., Chen, Y., Wang, G., Abdalla, M., Gao, L., Han, M., Shi, C., Li, A., Sun, P., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn1128 · Cited by 296
Cancer immunotherapy with γδ T cells: many paths ahead of us
Kabelitz, D., Serrano, R., Kouakanou, L., Peters, C., & Kalyan, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0504-x · Cited by 306
Control of human toxoplasmosis
Smith, N. C., Goulart, C., Hayward, J. A., Kupz, A., Miller, C., & van Dooren, G. G. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.11.001 · Cited by 330
Natural killer cell homing and trafficking in tissues and tumors: from biology to application
Ran, G., Lin, Y. Q., Tian, L., Zhang, T., Yan, D. M., Yu, J., & Deng, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01058-z · Cited by 304
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
Hu, Y., Zhou, Y., Zhang, M., Ge, W., Li, Y., Yang, L., Wei, G., Han, L., Wang, H., Yu, S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3863 · Cited by 296
CAR T cell therapies for patients with multiple myeloma
Mikkilineni, L., & Kochenderfer, J. N. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0427-6 · Cited by 277
Advances on immunotherapy for osteosarcoma
Yu, S., & Yao, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02105-9 · Cited by 270
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Background
NK cells and ILCs in tumor immunotherapy
Sivori, S., Pende, D., Quatrini, L., Pietra, G., Chiesa, M. D., Vacca, P., Tumino, N., Moretta, F., Mingari, M. C., Locatelli, F., et al. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100870 · Cited by 279
Challenges and new technologies in adoptive cell therapy
Zhang, P., Zhang, G., & Wan, X. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01492-8 · Cited by 291
Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders
Maskalenko, N. A., Zhigarev, D. I., & Campbell, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00413-7 · Cited by 265
Longevity leap: mind the healthspan gap
Garmany, A., Yamada, S., & Terzic, A. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00169-5 · Cited by 252
Clinical cancer immunotherapy: Current progress and prospects
Liu, C., Yang, M., Zhang, D., Chen, M., & Zhu, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961805 · Cited by 261
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
Chen, S., Zhu, H., & Jounaïdi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02005-w · Cited by 283
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy
Cichocki, F. M., Bjordahl, R., Gaidarova, S., Mahmood, S., Abujarour, R., Wang, H., Tuininga, K., Felices, M., Davis, Z., Bendzick, L. E., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz5618 · Cited by 249
Mechanisms of immune activation and regulation: lessons from melanoma
Kalaora, S., Nagler, A., Wargo, J. A., & Samuels, Y. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00442-9 · Cited by 252
BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial
Wang, W., He, S., Zhang, W., Zhang, H., DeStefano, V. M., Wada, M., Pinz, K. G., Deener, G., Shah, D., Hagag, N. G., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-225785 · Cited by 255
Self-citation
Treatment of Chronic Lymphocytic Leukemia
Burger, J. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1908213 · Cited by 243
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Farhangnia, P., Khorramdelazad, H., Nickho, H., & Delbandi, A. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01561-6 · Cited by 265
The Contribution of Epigenetics to Cancer Immunotherapy
Villanueva, L., Álvarez‐Errico, D., & Esteller, M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.06.002 · Cited by 238
SnapShot: Natural Killer Cells
Crinier, A., Narni-Mancinelli, É., Ugolini, S., & Vivier, É. (2020) · Cell · doi:10.1016/j.cell.2020.02.029 · Cited by 233
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results
Qi, C., Liu, C., Gong, J., Liu, D., Wang, X., Zhang, P., Qin, Y., Ge, S., Zhang, M., Peng, Z., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03037-z · Cited by 235
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Albinger, N., Hartmann, J., & Ullrich, E. (2021) · Gene Therapy · doi:10.1038/s41434-021-00246-w · Cited by 236
CAR-T: What Is Next?
Chen, Y., Abila, B., & Kamel, Y. M. (2023) · Cancers · doi:10.3390/cancers15030663 · Cited by 251
Allogeneic natural killer cell therapy
Berrien-Elliott, M. M., Jacobs, M. T., & Fehniger, T. A. (2022) · Blood · doi:10.1182/blood.2022016200 · Cited by 242
CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas
Gang, M., Marín, N. D., Wong, P., Neal, C. C., Marsala, L. I., Foster, M., Schappe, T., Meng, W., Tran, J., Schaettler, M. O., et al. (2020) · Blood · doi:10.1182/blood.2020006619 · Cited by 236
Exploiting innate immunity for cancer immunotherapy
Yi, M., Li, T., Niu, M., Mei, Q., Zhao, B., Chu, Q., Dai, Z., & Wu, K. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01885-w · Cited by 250
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
Ma, S., Caligiuri, M. A., & Yu, J. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.08.004 · Cited by 226
An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma
Ma, R., Lu, T., Li, Z., Teng, K., Mansour, A. G., Yu, M., Tian, L., Xu, B., Ma, S., Zhang, J., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0035 · Cited by 223
Development of NK cell-based cancer immunotherapies through receptor engineering
Page, A., Chuvin, N., Valladeau‐Guilemond, J., & Depil, S. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01145-x · Cited by 222
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Self-citation
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Human immunology and immunotherapy: main achievements and challenges
Varadé, J., Magadán, S., & González‐Fernández, Á. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00530-6 · Cited by 228
Engineering cytokine therapeutics
Deckers, J., Anbergen, T., Hokke, A. M., de Dreu, A., Schrijver, D. P., de Bruin, K., Toner, Y. C., Beldman, T. J., Spangler, J. B., de Greef, T. F. A., et al. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00030-y · Cited by 234
The future of engineered immune cell therapies
Irvine, D. J., Maus, M. V., Mooney, D. J., & Wong, W. W. (2022) · Science · doi:10.1126/science.abq6990 · Cited by 215
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results
Heczey, A. A., Xu, X. Y., Courtney, A. N., Tian, G., Barragán, G. A., Guo, L., Martínez-Amador, C., Ghatwai, N., Rathi, P., Wood, M. S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02363-y · Cited by 217
Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer
Cheng, W., Kang, K., Zhao, A., & Wu, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01581-2 · Cited by 229
Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies
Heipertz, E. L., Zynda, E. R., Stav-Noraas, T. E., Hungler, A. D., Boucher, S., Kaur, N., & Vemuri, M. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.732135 · Cited by 224
Advances in Universal CAR-T Cell Therapy
Lin, H., Cheng, J., Mu, W., Zhou, J., & Zhu, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.744823 · Cited by 215
NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis
Nersesian, S., Schwartz, S. L., Grantham, S. R., MacLean, L. K., Lee, S. N., Pugh-Toole, M., & Boudreau, J. E. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100930 · Cited by 197
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity
Ma, S., Yan, J., Barr, T., Zhang, J., Chen, Z., Wang, L., Sun, J. C.-Y., Chen, J., Caligiuri, M. A., & Yu, J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210279 · Cited by 202
Emerging Targeted Therapies for HER2-Positive Breast Cancer
Mercogliano, M. F., Bruni, S., Mauro, F. L., & Schillaci, R. (2023) · Cancers · doi:10.3390/cancers15071987 · Cited by 214
Metabolism in tumor microenvironment: Implications for cancer immunotherapy
Shi, R., Tang, Y., & Miao, H. (2020) · MedComm · doi:10.1002/mco2.6 · Cited by 210
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities
Magnani, C. F., Gaipa, G., Lussana, F., Belotti, D., Gritti, G., Napolitano, S., Matera, G., Cabiati, B., Buracchi, C., Borleri, G., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138473 · Cited by 201
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma
Makkouk, A., Yang, X., Barca, T., Lucas, A., Turkoz, M., Wong, J. T. S., Nishimoto, K. P., Brodey, M. M., Tabrizizad, M., Gundurao, S. R. Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003441 · Cited by 199
NK cells and solid tumors: therapeutic potential and persisting obstacles
Tong, L., Jiménez‐Cortegana, C., Tay, A. H. M., Wickström, S. L., Galluzzi, L., & Lundqvist, A. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01672-z · Cited by 197
Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics
Wang, W., Liu, X., Wu, S.-P., Chen, S., Li, Y., Nong, L., Lie, P., Huang, L., Cheng, L., Lin, Y., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa387 · Cited by 193
Natural Killer Cells: From Innate to Adaptive Features
Mujal, A. M., Delconte, R. B., & Sun, J. C.-Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-074948 · Cited by 199
CAR-NK cells for cancer immunotherapy: from bench to bedside
Zhang, L., Yuan, M., Feng, X., & Han, Z. (2022) · Biomarker Research · doi:10.1186/s40364-022-00364-6 · Cited by 195
Targeting public neoantigens for cancer immunotherapy
Pearlman, A. H., Hwang, M. S., Konig, M. F., Hsiue, E. H.-C., Douglass, J., DiNapoli, S. R., Mog, B. J., Bettegowda, C., Pardoll, D. M., Gabelli, S. B., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00210-y · Cited by 194
Successes and challenges in clinical gene therapy
Kohn, D. B., Chen, Y. Y., & Spencer, M. J. (2023) · Gene Therapy · doi:10.1038/s41434-023-00390-5 · Cited by 209
Innate lymphoid cells and cancer
Jacquelot, N., Seillet, C., Vivier, É., & Belz, G. T. (2022) · Nature Immunology · doi:10.1038/s41590-022-01127-z · Cited by 195
Natural killer cells: a promising immunotherapy for cancer
Chu, J., Gao, F., Yan, M., Zhao, S., Yan, Z., Shi, B., & Liu, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03437-0 · Cited by 194
Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
Kok, N., Panella, D., Georgoudaki, A., Liu, H., Özkazanç, D., Kučerová, L., Duru, A. D., Spanholtz, J., & Raimo, M. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01382-5 · Cited by 191
Applications of synthetic biology in medical and pharmaceutical fields
Yan, X., Liu, X., Zhao, C., & Chen, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01440-5 · Cited by 191
Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment
Kirchhammer, N., Trefny, M. P., der Maur, P. A., Laubli, H. P., & Zippelius, A. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo3605 · Cited by 182
Next-Generation CAR T-cell Therapies
Young, R. M., Engel, N. W., Uslu, U., Wellhausen, N., & June, C. H. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1683 · Cited by 191
KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape
Li, Y., Başar, R., Wang, G., Liu, E., Moyes, J. S. E., Li, L., Kerbauy, L. N., Uprety, N., Fathi, M., Rezvan, A., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02003-x · Cited by 191
Self-citation
Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies
Ruella, M., Korell, F., Porazzi, P., & Maus, M. V. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00807-1 · Cited by 197
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
Cui, X., & Snapper, C. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734471 · Cited by 179
Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities
Christodoulou, I., Ho, W. J., Marple, A., Ravich, J. W., Tam, A. J., Rahnama, R., Fearnow, A. D., Rietberg, C., Yanik, S. A., Solomou, E. E., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003894 · Cited by 184
NK cells are never alone: crosstalk and communication in tumour microenvironments
Zhou, Y., Lu, C. Y., Liu, L., & Li, X. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01737-7 · Cited by 183

Authors: Liu, E., Marin, D., Banerjee, P., Macapinlac, H. A., Thompson, P., Basar, R., Nassif Kerbauy, L., Overman, B., Thall, P., Kaplan, M., Nandivada, V., Kaur, I., Nunez Cortes, A., Cao, K., Daher, M., Hosing, C., Cohen, E. N., Kebriaei, P., Mehta, R., Neelapu, S., Nieto, Y., Wang, M., Wierda, W., Keating, M., Champlin, R., Shpall, E. J., & Rezvani, K.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
From the Departments of Stem Cell Transplantation and Cellular Therapy (E.L., D.M., P.B., R.B., L.N.K., B.O., M. Kaplan, V.N., I.K., A.N.C., M.D., C.H., P.K., R.M., Y.N., R.C., E.J.S., K.R.), Nuclear Medicine (H.A.M.), Leukemia (P. Thompson, W.W., M. Keating), Biostatistics (P. Thall), Laboratory Medicine (K.C.), Hematopathology (E.N.C.), and Lymphoma and Myeloma (S.N., M.W.), University of Texas M.D. Anderson Cancer Center, Houston.
ORCID: Liu, Enli
Banerjee, Pinaki
Macapinlac, Homer A.
Thompson, Philip
Thall, Peter
Kaplan, Mecit
Cao, Kai
Daher, May
Hosing, Chitra
Cohen, Evan N.
Kebriaei, Partow
Mehta, Rohtesh
Neelapu, Sattva
Nieto, Yago
Wang, Michael
Wierda, William
Keating, Michael
Champlin, Richard
Shpall, Elizabeth J.
Rezvani, Katayoun
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2020-02-06
Volume: 382
Issue: 6
Pages: 545-553
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1910607
PMC: PMC7101242
OpenAlex: W3004611567
Cited by: 2,217
References: 37
Citations by year: 2026: 282 · 2025: 337 · 2024: 332 · 2023: 323 · 2022: 353 · 2021: 379 · 2020: 205
FWCI: 113.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nejmgroup.org/legal/terms-of-use.htm (vor)
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: M.D. Anderson Cancer Center CLL and lymphoma Moonshot Grants
National Institutes of Health (1 R01 CA211044-01, 5P01CA148600-03, CA016672, P50CA100632-16)
Topics: Health Sciences › Medicine › Oncology › CAR-T cell therapy research
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: CAR-NK cells, chimeric antigen receptor, natural killer cells, anti-CD19, relapsed or refractory B-cell lymphoma, chronic lymphocytic leukemia, Richter transformation, lymphodepleting chemotherapy, cytokine release syndrome, neurotoxicity, graft-versus-host disease, interleukin-6, CAR T-cell toxicity
MeSH terms: Receptors, Chimeric Antigen, Aged, Female, Fetal Blood, Genetic Vectors, Humans, Killer Cells, Natural, Lymphoma, Non-Hodgkin, Male, Middle Aged, Remission Induction, Retroviridae, Leukemia, Lymphocytic, Chronic, B-Cell, Antigens, CD19, Transplantation Conditioning, Allografts, Cell- and Tissue-Based Therapy

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Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

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