Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer

André, Thierry, Shiu, Kai-Keen, Kim, Tae Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis, Smith, Denis, Garcia-Carbonero, Rocio +13 more·2020·New England Journal of Medicine

DOI 10.1056/nejmoa2017699

Cited by (1,003)

Items 301–400 of 1,003

Single-cell and spatial architecture of primary liver cancer
Pei‐Yun Zhou, Cheng Zhou, Wei Gan, Zheng Tang, Bao‐Ye Sun, Jinlong Huang, Gao Liu, Wei‐Ren Liu, Meng‐Xin Tian, Xi‐Fei Jiang et al. · 2023 · Communications Biology
Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma
Xu Yang, Baofeng Lian, Nan Zhang, Junyu Long, Yiran Li, Jingnan Xue, Xiangqi Chen, Yunchao Wang, Yanyu Wang, Ziyu Xun et al. · 2024 · BMC Medicine
Peritoneal Metastasis: Current Status and Treatment Options
Lilian Roth, Linda A. Russo, Sima Ulugöl, Rafael Freire dos Santos, Eva Breuer, Anurag Kumar Gupta, Kuno Lehmann · 2021 · Cancers
Avelumab vs Standard Second-Line Chemotherapy in Patients With Metastatic Colorectal Cancer and Microsatellite Instability
Julien Taı̈eb, Olivier Bouché, Thierry André, Karine Le Malicot, Pierre Laurent‐Puig, Jérémie Bez, Clémence Toullec, Christophe Borg, Violaine Randrian, Ludovic Evesque et al. · 2023 · JAMA Oncology
Immune-mediated liver injury from checkpoint inhibitors: mechanisms, clinical characteristics and management
Evangelos Triantafyllou, Cathrin L. C. Gudd, Lucia A. Possamai · 2024 · Nature Reviews Gastroenterology & Hepatology
BRAF V600E Mutation in First-Line Metastatic Colorectal Cancer: An Analysis of Individual Patient Data From the ARCAD Database
Romain Cohen, Heshan Liu, Jack Fiskum, Richard Adams, Benoist Chibaudel, Tim Maughan, Eric Van Cutsem, Alan Paul Venook, Jean‐Yves Douillard, Volker Heinemann et al. · 2021 · JNCI Journal of the National Cancer Institute
Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency
Cohen, Romain, Colle, Raphaël, Pudlarz, Thomas, Heran, Maximilien, Duval, Alex, Svrcek, Magali, André, Thierry · 2021 · Cancers
Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer
Federica Pecci, Luca Cantini, Alessandro Bittoni, Edoardo Lenci, Alessio Lupi, Sonia Crocetti, Enrica Giglio, Riccardo Giampieri, Rossana Berardi · 2021 · Current Treatment Options in Oncology
SEAMARK: phase II study of first-line encorafenib and cetuximab plus pembrolizumab for MSI-H/dMMR BRAF V600E-mutant mCRC
Elena Élez, Scott Kopetz, Josep M. Tabernero, Tanios Bekaii‐Saab, Julien Taı̈eb, Takayuki Yoshino, Gulam Abbas Manji, Kathrine C. Fernandez, Antonello Abbattista, Xiaosong Zhang et al. · 2023 · Future Oncology
Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer
Nadia Saoudi Gonzalez, Javier Ros, Iosune Baraibar, Francesc Salvà, Marta Rodríguez-Castells, Adriana Alcaráz, Ariadna García, Josep M. Tabernero, Elena Élez · 2024 · Cancers
The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types
Gil Awada, Tina Cascone, Michiel S. van der Heijden, Christian U. Blank, Marleen Kok, Myriam Chalabi · 2025 · Nature Cancer
Immune checkpoint inhibitors for the treatment of solid tumors and lymphoma in the past 26 years (2000–2025)
Liling Huang, Haohua Zhu, Yuankai Shi · 2025 · Journal of Hematology & Oncology
A Review of the Diagnosis and Treatment of Metastatic Colorectal Cancer—Reply
Leah H. Biller, Deborah Schrag · 2021 · JAMA
Integrating Molecular Biomarker Inputs Into Development and Use of Clinical Cancer Therapeutics
Anna D. Louie, Kelsey E. Huntington, Lindsey Carlsen, Lanlan Zhou, Wafik S. El‐Deiry · 2021 · Frontiers in Pharmacology
Somatic mutations in homologous recombination pathway predict favourable prognosis after immunotherapy across multiple cancer types
Zaoqu Liu, Chunguang Guo, Jing Li, Hui Xu, Taoyuan Lu, Libo Wang, Long Liu, Xinwei Han · 2021 · Clinical and Translational Medicine
Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene
Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M. Larabee, Cinthia Beskow Drachenberg, Harris G. Yfantis, Jean‐Pierre Raufman · 2022 · JCI Insight
Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation
Biying Zhang, Jiao Li, Qingling Hua, Haihong Wang, Guojie Xu, Jiayuan Chen, Ying Zhu, Ruiqi Li, Qing Duo Liang, Lanqing Wang et al. · 2023 · Journal for ImmunoTherapy of Cancer
Neoadjuvant Immunotherapy Leads to Major Response and Low Recurrence in Localized Mismatch Repair–Deficient Colorectal Cancer
Binyi Xiao, Xuan Zhang, Taiyuan Cao, Dandan Li, Jiang Wu, Ling-Heng Kong, Jinghua Tang, Kai Han, Chen-Zhi Zhang, Wei-Jian Mei et al. · 2023 · Journal of the National Comprehensive Cancer Network
Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoT RIBE study
Roberto Moretto, Daniele Rossini, Aurélie Catteau, Carlotta Antoniotti, Mirella Giordano, Alessandra Boccaccino, Clara Ugolini, Agnese Proietti, Veronica Conca, Alboukadel Kassambara et al. · 2023 · Journal for ImmunoTherapy of Cancer
Changes in Health Care Costs, Survival, and Time Toxicity in the Era of Immunotherapy and Targeted Systemic Therapy for Melanoma
Sarah B. Bateni, Paul Nguyen, Antoine E. Eskander, Soo Jin Seung, Nicole Mittmann, Matthew Jalink, Arjun Gupta, Kelvin Chan, Nicole J. Look Hong, Timothy Paul Hanna · 2023 · JAMA Dermatology
PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application
Luca Mastracci, Federica Grillo, Paola Parente, Irene Gullo, Michela Campora, Valentina Angerilli, Chiara Rossi, Maria Luísa Sacramento, Gianmaria Pennelli, Alessandro Vanoli et al. · 2022 · Pathologica
Genomic Landscape and Clinical Utility in Korean Advanced Pan-Cancer Patients from Prospective Clinical Sequencing: K-MASTER Program
Kyong Hwa Park, Jung Yoon Choi, Ah-Reum Lim, Ju Won Kim, Yoon Ji Choi, Soo Hyun Lee, Jae Sook Sung, Hee-Joon Chung, Byunghyun Jang, Dayoung Yoon et al. · 2021 · Cancer Discovery
Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck
Chi‐Yao Hsueh, Hui‐Ching Lau, Qiang Huang, Hongli Gong, Ji Sun, Pengyu Cao, Chunyan Hu, Ming Zhang, Lei Tao, Liang Fu Zhou · 2022 · Cancer
Diagnosis and Management of Rectal Cancer in Patients Younger Than 50 Years: Rising Global Incidence and Unique Challenges
Daenielle Lang, Kristen Keon Ciombor · 2022 · Journal of the National Comprehensive Cancer Network
Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study
Herbert Leon Duvivier, Michael Rothe, Pam K. Mangat, Elizabeth S. Garrett-Mayer, Eugene R. Ahn, Tareq Al Baghdadi, Ajjai Shivaram Alva, Stephanie A. Dublis, Timothy Lewis Cannon, Carmen Julia Calfa et al. · 2023 · Journal of Clinical Oncology
Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
Tao Tan, Dmitri Mouradov, Margaret Lee, Grace Gard, Yumiko Hirokawa, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu et al. · 2023 · Cell Reports Medicine
The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies
Haitao Wang, Rui Tang, Jiang Ling, Yingtian Jia · 2024 · Frontiers in Pharmacology
NCOA3 impairs the efficacy of anti-PD-L1 therapy via HSP90α/EZH2/CXCL9 axis in colon cancer
Jiaqi Liu, Yixi Su, Chi Zhang, Haiyan Dong, Runfeng Yu, Xin Yang, Yu Tian, Yanchun Feng, Jingdan Zhang, Mengchen Shi et al. · 2025 · International Immunopharmacology
The role of opioids in cancer response to immunotherapy
Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Bruna Cerbelli, Simone Scagnoli, Michela Roberto, Alain Jonathan Gelibter, Giulia Mammone, Maria Letizia Calandrella, Edoardo Cerbelli et al. · 2021 · Journal of Translational Medicine
LAG-3 Expression Predicts Outcome in Stage II Colon Cancer
Gaëlle Rhyner Agocs, Naziheh Assarzadegan, Richard Kirsch, Heather Dawson, José A. Galván, Alessandro Lugli, Inti Zlobec, Martin D. Berger · 2021 · Journal of Personalized Medicine
Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal Cancer
Catalano, Fabio, Borea, Roberto, Puglisi, Silvia, Boutros, Andrea, Gandini, Annalice, Cremante, Malvina, Martelli, Valentino, Sciallero, Stefania, Puccini, Alberto · 2022 · Cancers
B2M and JAK1/2–mutated MSI-H Colorectal Carcinomas Can Benefit From Anti-PD-1 Therapy
Chenzhi Zhang, Dandan Li, Binyi Xiao, Chi Zhou, Wu Jiang, Jinghua Tang, Yuan Li, Rongxin Zhang, Kai Han, Zhenlin Hou et al. · 2022 · Journal of Immunotherapy
CD155 in tumor progression and targeted therapy
Meixiao Zhan, Zhiren Zhang, Xiaoguang Zhao, Yuncong Zhang, Tianqing Liu, Ligong Lu, Xian-Yang Li · 2022 · Cancer Letters
Tumor-agnostic drug development in dMMR/MSI-H solid tumors
Deepak Bhamidipati, Vivek Subbiah · 2023 · Trends in cancer
Advancing translational research for colorectal immuno-oncology
E Thomas, Josephine A. Wright, Stephen J. Blake, Amanda J. Page, Daniel L. Worthley, Susan Lesley Woods · 2023 · British Journal of Cancer
Genomic instability as a driver and suppressor of anti-tumor immunity
Marta Requesens, Floris Foijer, Hans W. Nijman, Marco de Bruyn · 2024 · Frontiers in Immunology
Efficacy and Safety of Neoadjuvant Monoimmunotherapy With PD-1 Inhibitor for dMMR/MSI⁃H Locally Advanced Colorectal Cancer: A Single-Center Real-World Study
Xuan Zhang, Renfang Yang, Tao Wu, Xinyi Cai, Guoyu Li, Kun Yu, Yong Li, Rong Ding, Chao Dong, Jinsha Li et al. · 2022 · Frontiers in Immunology
CSCO guidelines for colorectal cancer version 2022: Updates and discussions
Zhijun Yuan, Shanshan Weng, Chenyang Ye, Hanguang Hu, Suzhan Zhang, Ying Yuan · 2022 · Chinese Journal of Cancer Research
Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA)
Nic Gabriel Reitsam, Bruno Märkl, Sebastian Dintner, Éva Sipos, Przemyslaw Grochowski, Bianca Grosser, Florian Sommer, Stefan Eser, Pia Nerlinger, Frank Alexander Jordan et al. · 2023 · Cancers
Primary tumour side as a driver for treatment choice in RAS wild-type metastatic colorectal cancer patients: a systematic review and pooled analysis of randomised trials
Daniele Rossini, Alessandra Boccaccino, Martina Carullo, Carlotta Antoniotti, Giovanni Dima, Paolo Ciracì, Federica Marmorino, Roberto Moretto, Gianluca Masi, Chiara Cremolini · 2023 · European Journal of Cancer
Comprehensive genomic profiling for oncological advancements by precision medicine
Maya Pankiw, Christine Brezden‐Masley, George S. Charames · 2023 · Medical Oncology
Potential predictive biomarkers in antitumor immunotherapy: navigating the future of antitumor treatment and immune checkpoint inhibitor efficacy
Xiangyu Yin, Xue Song, Wanglong Deng, NEIL W. BLAKE, Xinghong Luo, Jia Meng · 2024 · Frontiers in Oncology
RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients
Umberto Malapelle, Francesco Passiglia, Chiara Cremolini, Maria Lucia Reale, Francesco Pepe, Pasquale Pisapia, Antonio Avallone, Diego Luigi Cortinovis, Alfonso De Stefano, Matteo Fassan et al. · 2021 · European Journal of Cancer
Targeting KRAS G12C with Covalent Inhibitors
Jonathan M. L. Ostrem, Kevan M. Shokat · 2021 · Annual Review of Cancer Biology
Regorafenib in combination with immune checkpoint inhibitors for mismatch repair proficient (pMMR)/microsatellite stable (MSS) colorectal cancer
Tuğba Akın Telli, Giacomo Bregni, Michele Vanhooren, Rita Saúde-Conde, Alain Hendlisz, Francesco Sclafani · 2022 · Cancer Treatment Reviews
Targeting DNA Damage Response and Immune Checkpoint for Anticancer Therapy
Huang, Jau-Ling, Chang, Yu-Tzu, Hong, Zhen-Yang, Lin, Chang-Shen · 2022 · International Journal of Molecular Sciences
Clinical benefits of PD-1/PD-L1 inhibitors in patients with metastatic colorectal cancer: a systematic review and meta-analysis
Xiao Zhang, Zhengyang Yang, Yongbo An, Yishan Liu, Qi Wei, Fengming Xu, Hongwei Yao, Zhongtao Zhang · 2022 · World Journal of Surgical Oncology
Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Kai He, Zhihan Wang, Maochao Luo, Bowen Li, Ning Ding, Lei Li, Bo He, Han Wang, Jiangjun Cao, Canhua Huang et al. · 2023 · Journal of Translational Medicine
Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn M. Kljavin, Sarah Gierke, Alexis Scherl, James M. Ziai, Erin McNamara et al. · 2023 · Nature Communications
Anti‐angiogenic therapy enhances cancer immunotherapy: Mechanism and clinical application
An‐Qi Li, Jian‐Hong Fang · 2024 · Interdisciplinary medicine
Late-line options for patients with metastatic colorectal cancer: a review and evidence-based algorithm
Paolo Ciracì, Vittorio Studiale, Ada Taravella, Carlotta Antoniotti, Chiara Cremolini · 2024 · Nature Reviews Clinical Oncology
Centromere Protein F (CENPF) Serves as a Potential Prognostic Biomarker and Target for Human Hepatocellular Carcinoma
Yugang Huang, Xiuwen Chen, Li Wang, Tieyan Wang, Xian-bin Tang, Xiaomin Su · 2021 · Journal of Cancer
The EMA assessment of pembrolizumab as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer
Ana Trullas, Julio Delgado, Armando A. Genazzani, Jan Mueller-Berghaus, Cristina Migali, S. Müller-Egert, Hilke Zander, Harald G. Enzmann, Francesco Pignatti · 2021 · ESMO Open
Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases
Pieter M. H. Nierop, Diederik J. Höppener, Florian E. Buisman, Eric P. van der Stok, Boris Galjart, Vinod P. Balachandran, William R. Jarnagin, T. Peter Kingham, Jinru Shia, Murielle E.L. Mauer et al. · 2021 · The Journal of Pathology Clinical Research
Primary and metastatic peritoneal surface malignancies
2021 · Nature Reviews Disease Primers
Optimal Neoadjuvant Strategies for Locally Advanced Rectal Cancer by Risk Assessment and Tumor Location
Anurag Saraf, Hannah Johnson Roberts, Jennifer Yon-Li Wo, Aparna R. Parikh · 2022 · Journal of the National Comprehensive Cancer Network
Advances in pharmacokinetics and pharmacodynamics of PD-1/PD-L1 inhibitors
Ting Yan, Lun Yu, Dangang Shangguan, Wěi Li, Ni Liu, Yun Chen, Yilan Fu, Jingyi Tang, Dehua Liao · 2022 · International Immunopharmacology
Cancer Therapy Guided by Mutation Tests: Current Status and Perspectives
Aleksakhina, Svetlana N., Imyanitov, Evgeny N. · 2021 · International Journal of Molecular Sciences
Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy
Siyuan Cheng, Zihan Han, Die Dai, Fang Li, Xiaotian Zhang, Ming Shian Lu, Zhihao Lü, Xicheng Wang, Jun Zhou, Jian Li et al. · 2024 · Cell Reports Medicine
Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on Biomarkers
Areti D. Strati, Christos Adamopoulos, Ioannis Kotsantis, Amanda K. Psyrri, Evi S. Lianidou, Athanasios G. Papavassiliou · 2025 · International Journal of Molecular Sciences
Expanding Therapeutic Opportunities for Extrapulmonary Neuroendocrine Carcinoma
Melissa Frizziero, Elaine Kilgour, Kathryn Simpson, Dominic G. Rothwell, David Allan Moore, Kristopher K. Frese, Melanie Galvin, Ángela Lamarca, Richard A Hubner, Juan W. Valle et al. · 2022 · Clinical Cancer Research
Neoantigen: A Promising Target for the Immunotherapy of Colorectal Cancer
Yue Zheng, Yang Fu, Peipei Wang, Zhenyu Ding · 2022 · Disease Markers
BRAF V600E/RAS Mutations and Lynch Syndrome in Patients With MSI-H/dMMR Metastatic Colorectal Cancer Treated With Immune Checkpoint Inhibitors
Raphaël Colle, Sara Lonardi, Marine Cachanado, Michael James Overman, Elena Élez, Marwan Fakih, Francesca Corti, Priya Jayachandran, Magali Svrcek, Antoine Dardenne et al. · 2023 · The Oncologist
Immunotherapy: Recent Advances and Its Future as a Neoadjuvant, Adjuvant, and Primary Treatment in Colorectal Cancer
Yu, Irene, Dakwar, Anthony, Takabe, Kazuaki · 2023 · Cells
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong et al. · 2022 · Journal for ImmunoTherapy of Cancer
Preliminary clinical study of personalized neoantigen vaccine therapy for microsatellite stability (MSS)-advanced colorectal cancer
Yaojun Yu, Na Shan, Liyi Li, Yuesheng Zhu, Limiao Lin, Chenchen Mao, Tingting Hu, Xiangyang Xue, Xiaoping Su, Xian Shen et al. · 2023 · Cancer Immunology Immunotherapy
Liver transplantation in metastatic colorectal cancer: are we ready for it?
Javier Ros, Francesc Salvà, Cristina Dopazo, D. López-Valbuena, Nadia Saoudi Gonzalez, Iosune Baraibar, Ramón Charco, Josep M. Tabernero, Elena Élez · 2023 · British Journal of Cancer
Targeted Therapies in Colorectal Cancer: Recent Advances in Biomarkers, Landmark Trials, and Future Perspectives
Joao Lucas Lima Manzi, Camilla Oliveira Hoff, Raphaella Ferreira, Agustin Pimentel, Jashodeep Datta, Alan S. Livingstone, Rodrigo Vianna, Phillipe Abreu · 2023 · Cancers
“De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade
Sara Hadad, Rohit K. Gupta, Nancy Ann Oberheim Bush, Jennie Webster Taylor, Javier E. Villanueva-Meyer, Jacob S. Young, Jasper Wu, Ajay Ravindranathan, Yalan Zhang, Gayathri Warrier et al. · 2023 · Acta Neuropathologica
State-of-the-Art Management of Colorectal Cancer: Treatment Advances and Innovation
Priyadarshini Pathak, Gloria Hui Jia Chan, Dustin A. Deming, Cheng Ean Chee · 2024 · American Society of Clinical Oncology Educational Book
FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy
Jian‐Hao Chen, Yangfan Zhou, Yizhen Pang, Kaili Fu, Qicong Luo, Long Sun, Hua Wu, Qin Lin, Guoqiang Su, Xiaoyuan Shawn Chen et al. · 2025 · Journal for ImmunoTherapy of Cancer
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies
Marwa Abdel Hamid, Lorenz Michael Pammer, Silvia Oberparleiter, Michael Günther, Arno Amann, Rebecca Gruber, Anna Mair, Fabienne I. Nocera, Steffen Ormanns, Kai Zimmer et al. · 2025 · npj Precision Oncology
Beyond RAS and BRAF: HER2, a New Actionable Oncotarget in Advanced Colorectal Cancer
Chiara Guarini, Teresa Grassi, Gaetano Pezzicoli, Camillo Porta · 2021 · International Journal of Molecular Sciences
Stem Cell Theory of Cancer: Origin of Tumor Heterogeneity and Plasticity
Shi‐Ming Tu, Miao Zhang, Christopher G. Wood, Louis L. Pisters · 2021 · Cancers
The CIRCULATE Trial: Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation (AIO-KRK-0217)
Gunnar Folprecht, Anke Reinacher‐Schick, Jürgen Weitz, Céline Lugnier, Anna‐Lena Kraeft, Sarah Wisser, Daniela Ellen Aust, Lukas Weiß, Nikolas C. C. von Bubnoff, Michael Krämer et al. · 2021 · Clinical Colorectal Cancer
Immune checkpoint blockade in the treatment of malignant tumor: current statue and future strategies
Wenwen Yang, Caining Lei, Shaoming Song, Wutang Jing, Chuanwei Jin, Shiyi Gong, Hongwei Tian, Tiankang Guo · 2021 · Cancer Cell International
Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer
Michael Joe Duffy, John Paul Crown · 2022 · Journal of Personalized Medicine
Neoadjuvant immunotherapy of locoregionally advanced solid tumors
Ahmad A. Tarhini, Jennifer Rachel Eads, Kathleen N. Moore, Valerie M. Tatard-Leitman, John Wright, Patrick M. Forde, Robert Louis Ferris · 2022 · Journal for ImmunoTherapy of Cancer
Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal Cancer
Thomas J. Roberts, Kenneth L. Kehl, Gabriel A. Brooks, Lynette Marie Sholl, Alexi A. Wright, Mary Beth Landrum, Nancy Lynn Keating · 2023 · JAMA Network Open
Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
Amodio, Vito, Lamba, Simona, Chilà, Rosaria, Cattaneo, Chiara M., Mussolin, Benedetta, Corti, Giorgio, Rospo, Giuseppe, Berrino, Enrico, Tripodo, Claudio, Pisati, Federica et al. · 2023 · Cancer Cell
Current and emerging concepts for systemic treatment of metastatic colorectal cancer
Steup, Christoph, Kennel, Kilian B, Neurath, Markus F, Fichtner-Feigl, Stefan, Greten, Florian R · 2025 · Gut
Colorectal Cancer Immunotherapy: State of the Art and Future Directions
Cornista, Alyssa Mauri, Giolito, Maria Virginia, Baker, Kristi, Hazime, Hajar, Dufait, Inès, Datta, Jashodeep, Khumukcham, Saratchandra Singh, De Ridder, Mark, Roper, Jatin, Abreu, Maria T. et al. · 2023 · Gastro Hep Advances
Soluble PD-L1: a potential dynamic predictive biomarker for immunotherapy in patients with proficient mismatch repair colorectal cancer
Yinjun He, Xiang Zhang, Ming Qiao Zhu, Wenguang He, Hanju Hua, Feng Ye, Xile Zhou, Nan Chen, Yandong Li, Weixiang Zhong et al. · 2023 · Journal of Translational Medicine
Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E‐stained images: achieving state‐of‐the‐art predictive performance with fewer data using Swin Transformer
Bangwei Guo, Xingyu Li, Miaomiao Yang, Jitendra Jonnagaddala, Hong Zhang, Steven X. Xu · 2023 · The Journal of Pathology Clinical Research
Predictive biomarkers for immune checkpoint inhibitor response in urothelial cancer
Pauline Parent, Gautier Marcq, Sola Michael Adeleke, Anthony Turpin, Stergios Boussios, Elie Rassy, Nicolas Penel · 2023 · Therapeutic Advances in Medical Oncology
Anti-EGFR Antibodies in the Management of Advanced Colorectal Cancer
Pashtoon Murtaza Kasi, Manuel Geroy Afable, Cameron J. Herting, Mariusz Lukanowski, Zhaohui Jin · 2023 · The Oncologist
Risk and Incidence of Endocrine Immune-Related Adverse Effects Under Checkpoint Inhibitor Mono- or Combination Therapy in Solid Tumors: A Meta-Analysis of Randomized Controlled Trials
Irfan Vardarli, Susanne Tan, Tim Brandenburg, Frank Weidemann, Rainer Görges, Ken Herrmann, Dagmar Führer · 2023 · The Journal of Clinical Endocrinology & Metabolism
68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer
Ké Li, Wei Liu, Hang Yu, Jiwei Chen, Wenxuan Tang, Jianpeng Wang, Ming Qi, Yuyun Sun, Xiaoping Xu, Ji Zhang et al. · 2024 · Journal of Clinical Investigation
Generating and using real-world data: A worthwhile uphill battle
K. Verkerk, Emile E. Voest · 2024 · Cell
Immunotherapy for colorectal cancer
Bing Yu, Jian Kang, Hong Lei, Zhe Li, Hao Chun Yang, Meng Zhang · 2024 · Frontiers in Immunology
Adjuvant Chemotherapy for Gastric Cancer Patients with Mismatch Repair Deficiency or Microsatellite Instability: Systematic Review and Meta-Analysis
Run Cong Nie, Guo Ming Chen, Shu Qiang Yuan, Jin Won Kim, Jie Zhou, Man Nie, Chen Yang Feng, Yingbo Chen, Shi Chen, Zhi Zhou et al. · 2021 · Annals of Surgical Oncology
Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer
Alyssa Schledwitz, Margaret H. Sundel, Madeline A. Alizadeh, Shien Hu, Guofeng Xie, Jean‐Pierre Raufman · 2021 · International Journal of Molecular Sciences
Upper Tract Urothelial Carcinoma in the Lynch Syndrome Tumour Spectrum: A Comprehensive Overview from the European Association of Urology - Young Academic Urologists and the Global Society of Rare Genitourinary Tumors
Chiara Lonati, Andrea Necchi, Juan Gómez Rivas, Luca Afferi, Ekaterina Laukhtina, Alberto Martini, Eugenio Ventimiglia, Renzo Colombo, Giorgio Gandaglia, Andrea Salonia et al. · 2021 · European Urology Oncology
Pembrolizumab in MSI-H–dMMR Advanced Colorectal Cancer — A New Standard of Care
Axel F. Grothey · 2020 · New England Journal of Medicine
Envafolimab – first PD-1/PD-L1 antibody to be administered by subcutaneous injection for microsatellite instability-high or deficient mismatch repair advanced solid tumors
Mifen Chen, Mengyun Jiang, Xinhui Wang, Lin Shen, Jian Li · 2022 · Expert Opinion on Biological Therapy
Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition
Bianca Medici, B. Riccò, Eugenia Caffari, Silvia Zaniboni, Massimiliano Salati, Andrea Spallanzani, Ingrid Garajová, Stefania Benatti, Chiara Chiavelli, Massimo Dominici et al. · 2023 · Cancers
Biomarkers of Pathologic Complete Response to Neoadjuvant Immunotherapy in Mismatch Repair–Deficient Colorectal Cancer
Jianxia Li, Huabin Hu, Ge Qin, Fan Bai, Xianrui Wu, Haoxian Ke, Jianwei Zhang, Yuqian Xie, Zehua Wu, Yang Fu et al. · 2023 · Clinical Cancer Research
Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis
Xiaosheng Lin, Hongwu Chen, Tingting Deng, Binghui Cai, Yubin Xia, Lei Xie, Huaiming Wang, Cong Huang · 2024 · ACS Applied Materials & Interfaces
Artificial Intelligence for Predicting Microsatellite Instability Based on Tumor Histomorphology: A Systematic Review
Ji Hyun Park, Eun Young Kim, Claudio Luchini, Albino Eccher, Kalthoum Tizaoui, Jae Il Shin, Beom Jin Lim · 2022 · International Journal of Molecular Sciences
Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, Taxiarchis Konstantinos, Chrysos, Emmanuel, Docea, Anca Oana, Fragkiadaki, Persefoni, Souglakos, John, Tsiaoussis, John, Tsatsakis, Aristidis · 2024 · Cancers