CoChat
Sign Up
Cited by 649Mosquito-borne diseases and controlInsect symbiosis and bacterial influencesDengue and Mosquito Control Research

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue

Open access
Utarini, Adi, Indriani, Citra, Ahmad, Riris A., Tantowijoyo, Warsito, Arguni, Eggi, Ansari, M. Ridwan, Supriyati, Endah, Wardana, D. Satria, Meitika, Yeti, Ernesia, Inggrid, Nurhayati, Indah, Prabowo, Equatori, Andari, Bekti, Green, Benjamin R., Hodgson, Lauren, Cutcher, Zoe, Rancès, Edwige, Ryan, Peter A., O’Neill, Scott L., Dufault, Suzanne M., Tanamas, Stephanie K., Jewell, Nicholas P., Anders, Katherine L., Simmons, Cameron P.·2021·New England Journal of Medicine
DOI 10.1056/nejmoa2030243PMC PMC8103655
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUNDAedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis are less susceptible than wild-type A. aegypti to dengue virus infection. METHODSWe conducted a cluster-randomized trial involving releases of wMel-infected A. aegypti mosquitoes for the control of dengue in Yogyakarta, Indonesia.We randomly assigned 12 geographic clusters to receive deployments of wMel-infected A. aegypti (intervention clusters) and 12 clusters to receive no deployments (control clusters).All clusters practiced local mosquito-control measures as usual.A testnegative design was used to assess the efficacy of the intervention.Patients with acute undifferentiated fever who presented to local primary care clinics and were 3 to 45 years of age were recruited.Laboratory testing was used to identify participants who had virologically confirmed dengue (VCD) and those who were testnegative controls.The primary end point was symptomatic VCD of any severity caused by any dengue virus serotype. RESULTSAfter successful introgression of wMel into the intervention clusters, 8144 participants were enrolled; 3721 lived in intervention clusters, and 4423 lived in control clusters.In the intention-to-treat analysis, VCD occurred in 67 of 2905 participants (2.3%) in the intervention clusters and in 318 of 3401 (9.4%) in the control clusters (aggregate odds ratio for VCD, 0.23; 95% confidence interval [CI], 0.15 to 0.35; P = 0.004).The protective efficacy of the intervention was 77.1% (95% CI, 65.3 to 84.9) and was similar against the four dengue virus serotypes.The incidence of hospitalization for VCD was lower among participants who lived in intervention clusters (13 of 2905 participants [0.4%]) than among those who lived in control clusters (102 of 3401 [3.0%]) (protective efficacy, 86.2%; 95% CI, 66.2 to 94.3). CONCLUSIONSIntrogression of wMel into A. aegypti populations was effective in reducing the incidence of symptomatic dengue and resulted in fewer hospitalizations for dengue among the participants.(Funded by the Tahija Foundation and others; AWED ClinicalTrials.govnumber, NCT03055585; Indonesia Registry number, INA-A7OB6TW.)

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejmoa2030243

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 33 references

Research works printed but not linked: 1

  1. Department of Control of Neglected Tropical Diseases, Special Programme for Research and Training in Tropical Diseases. Dengue: guidelines for diagnosis, treatment, prevention and control. Geneva: World Health Organization, 2009.

Cited by

Sorted by citations

Items 401–500 of 648

Related

See all

Metadata

Authors
Utarini, A., Indriani, C., Ahmad, R. A., Tantowijoyo, W., Arguni, E., Ansari, M. R., Supriyati, E., Wardana, D. S., Meitika, Y., Ernesia, I., Nurhayati, I., Prabowo, E., Andari, B., Green, B. R., Hodgson, L., Cutcher, Z., Rancès, E., Ryan, P. A., O’Neill, S. L., Dufault, S. M., Tanamas, S. K., Jewell, N. P., Anders, K. L., & Simmons, C. P.
Affiliations
Universitas Gadjah Mada (ID)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2021-06-10
Volume
384
Issue
23
Pages
2177-2186
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa2030243
PMC
PMC8103655
OpenAlex
W3172070999
Cited by
649
References
33
Citations by year
2026: 121 · 2025: 143 · 2024: 127 · 2023: 121 · 2022: 96 · 2021: 40
FWCI
84.34
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • New England Journal of Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
Funders
  • Wellcome Trust (212914)
  • National Institute of Allergy and Infectious Diseases (R01AI148127)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect symbiosis and bacterial influences
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Dengue and Mosquito Control Research
Keywords
Wolbachia, wMel strain, Aedes aegypti, dengue control, mosquito release, dengue virus, test-negative design, protective efficacy, dengue hospitalization, mosquito control, Yogyakarta, dengue serotypes, dengue surveillance, dengue prevention
MeSH terms
Mosquito Vectors, Adolescent, Adult, Aedes, Animals, Child, Child, Preschool, Communicable Disease Control, Dengue, Dengue Virus, Female, Humans, Indonesia, Male, Middle Aged, Incidence, Wolbachia, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review