The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery
Open accessAbstract
BACKGROUND: Patients with three-vessel coronary artery disease have been found to have better outcomes with coronary-artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI), but studies in which PCI is guided by measurement of fractional flow reserve (FFR) have been lacking. METHODS: In this multicenter, international, noninferiority trial, patients with three-vessel coronary artery disease were randomly assigned to undergo CABG or FFR-guided PCI with current-generation zotarolimus-eluting stents. The primary end point was the occurrence within 1 year of a major adverse cardiac or cerebrovascular event, defined as death from any cause, myocardial infarction, stroke, or repeat revascularization. Noninferiority of FFR-guided PCI to CABG was prespecified as an upper boundary of less than 1.65 for the 95% confidence interval of the hazard ratio. Secondary end points included a composite of death, myocardial infarction, or stroke; safety was also assessed. RESULTS: A total of 1500 patients underwent randomization at 48 centers. Patients assigned to undergo PCI received a mean (±SD) of 3.7±1.9 stents, and those assigned to undergo CABG received 3.4±1.0 distal anastomoses. The 1-year incidence of the composite primary end point was 10.6% among patients randomly assigned to undergo FFR-guided PCI and 6.9% among those assigned to undergo CABG (hazard ratio, 1.5; 95% confidence interval [CI], 1.1 to 2.2), findings that were not consistent with noninferiority of FFR-guided PCI (P = 0.35 for noninferiority). The incidence of death, myocardial infarction, or stroke was 7.3% in the FFR-guided PCI group and 5.2% in the CABG group (hazard ratio, 1.4; 95% CI, 0.9 to 2.1). The incidences of major bleeding, arrhythmia, and acute kidney injury were higher in the CABG group than in the FFR-guided PCI group. CONCLUSIONS: In patients with three-vessel coronary artery disease, FFR-guided PCI was not found to be noninferior to CABG with respect to the incidence of a composite of death, myocardial infarction, stroke, or repeat revascularization at 1 year. (Funded by Medtronic and Abbott Vascular; FAME 3 ClinicalTrials.gov number, NCT02100722.).
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Serruys, P. W., Morice, M.-C., Kappetein, A. P., Colombo, A., Holmes, D. R., Mack, M. J., Ståhle, E., Feldman, T. E., van den Brand, M., Bass, E. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804626 · Cited by 4,331
Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention
Tonino, P. A. L., De Bruyne, B., Pijls, N. H. J., Siebert, U., Ikeno, F., van `t Veer, M., Klauss, V., Manoharan, G., Engstrøm, T., Oldroyd, K. G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807611 · Cited by 4,260
Self-citationFourth Universal Definition of Myocardial Infarction (2018)
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., & White, H. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.1038 · Cited by 4,118
Third Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., White, H. D., Thygesen, K., Alpert, J. S., White, H. D., Jaffe, A. S., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.001 · Cited by 2,621
Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh, M. E., Domanski, M., Sleeper, L. A., Siami, F. S., Dangas, G., Mack, M., Yang, M., Cohen, D. J., Rosenberg, Y., Solomon, S. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211585 · Cited by 1,922
Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease
Stone, G. W., Sabik, J. F., Serruys, P. W., Simonton, C. A., Généreux, P., Puskas, J., Kandzari, D. E., Morice, M.-C., Lembo, N., Brown, W. M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610227 · Cited by 1,068
Self-citationFractional Flow Reserve–Guided PCI for Stable Coronary Artery Disease
De Bruyne, B., Fearon, W. F., Pijls, N. H. J., Barbato, E., Tonino, P., Piroth, Z., Jagic, N., Mobius-Winckler, S., Rioufol, G., Witt, N., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408758 · Cited by 1,062
Self-citationFive-Year Outcomes with PCI Guided by Fractional Flow Reserve
Xaplanteris, P., Fournier, S., Pijls, N. H. J., Fearon, W. F., Barbato, E., Tonino, P. A. L., Engstrøm, T., Kääb, S., Dambrink, J.-H., Rioufol, G., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803538 · Cited by 866
Self-citationMäkikallio, T., Holm, N. R., Lindsay, M., Spence, M. S., Erglis, A., Menown, I. B. A., Trovik, T., Eskola, M., Romppanen, H., Kellerth, T., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32052-9 · Cited by 772
Self-citationIntravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation
Zhang, J., Gao, X., Kan, J., Ge, Z., Han, L., Lu, S., Tian, N., Lin, S., Lu, Q., Wu, X., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.013 · Cited by 665
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2024 ESC Guidelines for the management of chronic coronary syndromes
Vrints, C., Andreotti, F., Koskinas, K. C., Rossello, X., Adamo, M., Ainslie, J., Banning, A. P., Budaj, A., Buechel, R. R., Chiariello, G. A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae177 · Cited by 2,774
Self-citationVirani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
Self-citationVirani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.04.003 · Cited by 596
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Metadata
- Authors
- Fearon, W. F., Zimmermann, F. M., De Bruyne, B., Piroth, Z., van Straten, A. H. M., Szekely, L., Davidavičius, G., Kalinauskas, G., Mansour, S., Kharbanda, R., Östlund-Papadogeorgos, N., Aminian, A., Oldroyd, K. G., Al-Attar, N., Jagic, N., Dambrink, J.-H. E., Kala, P., Angerås, O., MacCarthy, P., Wendler, O., Casselman, F., Witt, N., Mavromatis, K., Miner, S. E. S., Sarma, J., Engstrøm, T., Christiansen, E. H., Tonino, P. A. L., Reardon, M. J., Lu, D., Ding, V. Y., Kobayashi, Y., Hlatky, M. A., Mahaffey, K. W., Desai, M., Woo, Y. J., Yeung, A. C., & Pijls, N. H. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2022-01-13
- Volume
- 386
- Issue
- 2
- Pages
- 128-137
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3211158953
- Cited by
- 359
- References
- 18
- FWCI
- 51.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fearon, W. F., Zimmermann, F. M., De Bruyne, B., Piroth, Z., van Straten, A. H. M., Szekely, L., Davidavičius, G., Kalinauskas, G., Mansour, S., Kharbanda, R., Östlund-Papadogeorgos, N., Aminian, A., Oldroyd, K. G., Al-Attar, N., Jagic, N., Dambrink, J.-H. E., Kala, P., Angerås, O., MacCarthy, P., . . . Pijls, N. H. J. (2022). Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2112299
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