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Cited by 184Xenotransplantation and immune responseAnimal Genetics and ReproductionRenal Transplantation Outcomes and Treatments

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease

Kawai, Tatsuo, Williams, Winfred W., Elias, Nahel, Fishman, Jay A., Crisalli, Kerry, Longchamp, Alban, Rosales, Ivy A., Duggan, Michael, Kimura, Shoko, Morena, Leela, Borges, Thiago J., Tomosugi, Toshihide, Karadagi, Ahmad, Nakamura, Tsukasa, Safa, Kassem, Giarraputo, Alessia, Avillach, Claire T., Patalas, Eva D., Smith, R. Neal, Sachs, David H., Cosimi, A. Benedict, Madsen, Joren C., Cooper, David K.C., Pierson, Richard, Perrin, Steve, Anand, Ranjith P., Chhangawala, Sagar, Coscarella, Matthew, Daigneault, Alexandre, Li, Feng, Pearce, Owen, Qin, Wenning, Serkin, William T., Yeung, Vincent, Getchell, Kristen, Low, Susan C., Curtis, Michael, Colvin, Robert B., Riella, Leonardo V.·2025·New England Journal of Medicine
DOI 10.1056/nejmoa2412747
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Abstract

Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges received a gene-edited porcine kidney with 69 genomic edits, including deletion of three glycan antigens, inactivation of porcine endogenous retroviruses, and insertion of seven human transgenes. The xenograft functioned immediately. The patient's creatinine levels decreased promptly and progressively, and dialysis was no longer needed. After a T-cell-mediated rejection episode on day 8, intensified immunosuppression reversed rejection. Despite sustained kidney function, the patient died from unexpected, sudden cardiac causes on day 52; autopsy revealed severe coronary artery disease and ventricular scarring without evident xenograft rejection. (Funded by Massachusetts General Hospital and eGenesis.).

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Crossref · 10.1056/nejmoa2412747

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Metadata

Authors
Kawai, T., Williams, W. W., Elias, N., Fishman, J. A., Crisalli, K., Longchamp, A., Rosales, I. A., Duggan, M., Kimura, S., Morena, L., Borges, T. J., Tomosugi, T., Karadagi, A., Nakamura, T., Safa, K., Giarraputo, A., Avillach, C. T., Patalas, E. D., Smith, R. N., Sachs, D. H., Cosimi, A. B., Madsen, J. C., Cooper, D. K. C., Pierson, R., Perrin, S., Anand, R. P., Chhangawala, S., Coscarella, M., Daigneault, A., Li, F., Pearce, O., Qin, W., Serkin, W. T., Yeung, V., Getchell, K., Low, S. C., Curtis, M., Colvin, R. B., & Riella, L. V.
Affiliations
  • Harvard University (US)
  • Transplant Center, Massachusetts General Hospital, Boston
  • Eledon Pharmaceuticals, Irvine, CA
  • eGenesis, Cambridge, MA
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2025-05-15
Volume
392
Issue
19
Pages
1933-1940
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa2412747
OpenAlex
W4407259548
Semantic Scholar
dc3137c82b6a5c9c96b26a1d6d2806b17cea3a4a
Cited by
184
References
12
Citations by year
2026: 112 · 2025: 72
FWCI
128.84
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (U19AI090959)
Topics
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
Keywords
xenotransplantation, porcine kidney, end-stage renal disease, gene-edited pigs, porcine endogenous retroviruses, T cell-mediated rejection, immunosuppression, hemodialysis dependence, diabetes mellitus, coronary artery disease, organ shortage
MeSH terms
Animals, Coronary Artery Disease, Graft Rejection, Humans, Immunosuppressive Agents, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Swine, Transplantation, Heterologous, Kidney Transplantation, Fatal Outcome, Animals, Genetically Modified, Heterografts

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