The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Antidepressants' Black-Box Warning — 10 Years Later
Open accessAbstract
In 2004, the FDA issued a black-box warning linking antidepressants to an increased risk of suicidal thinking, feeling, and behavior in young people. But some worrisome trends suggest that the warning may inadvertently discourage appropriate treatment of depression.
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In the citing paper
“slight impairments in executive control 207,210 and memory 207 may remain”
From Major depressive disorder (2016) · cites this paper as [207]
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In the citing paper
“One meta-analysis identified executive function, memory, and attention as the predominantly affected domains 207 .”
From Major depressive disorder (2016) · cites this paper as [207]
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In the citing paper
“Although the cognitive deficits are more modest after remission (i.e. in euthymic patients with MDD)”
From Major depressive disorder (2016) · cites this paper as [207]
Experimental — accuracy not yet measuredIn the citing paper
“Moreover, the meta-analysis which lead to the black box warning in fact showed that rate of suicidal thinking or suicidal behavior was 4% among patients being prescribed an antidepressant, as compared with 2% among those being taken placebo.58”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [58]
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Cites
Lu, C. Y., Zhang, F., Lakoma, M. D., Madden, J. M., Rusinak, D., Penfold, R. B., Simon, G. E., Ahmedani, B. K., Clarke, G. N., Hunkeler, E. M., et al. (2014) · BMJ · doi:10.1136/bmj.g3596 · Cited by 229
Suicide among adults aged 35-64 years--United States, 1999-2010.
Sullivan, E., Annest, J. L., Luo, F., Simon, T. R., & Dahlberg, L. L. (2013) · PubMed Central · Cited by 155
Persisting Decline in Depression Treatment After FDA Warnings
Libby, A. M., Orton, H. D., & Valuck, R. J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.46 · Cited by 153
Valuck, R. J., Libby, A. M., Orton, H. D., Morrato, E. H., Allen, R. R., & Baldessarini, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010007 · Cited by 137
The FDA Warning on Antidepressants and Suicidality — Why the Controversy?
Stone, M. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1411138 · Cited by 45
Flagged first, then by citations
Research works printed but not linked: 1
- 2013, MMWR Morb Mortal Wkly Rep, 62, 321
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Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269
Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review
Wang, S.-M., Han, C., Bahk, W.-M., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C.-U. (2018) · Chonnam Medical Journal · doi:10.4068/cmj.2018.54.2.101 · Cited by 299
Suicide risk assessment and intervention in people with mental illness
Bolton, J. M., Gunnell, D., & Turecki, G. (2015) · BMJ · doi:10.1136/bmj.h4978 · Cited by 294
Lenze, E. J., Mulsant, B. H., Blumberger, D. M., Karp, J. F., Newcomer, J. W., Anderson, S. J., Dew, M. A., Butters, M. A., Stack, J. A., Begley, A. E., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00308-6 · Cited by 283
Andrews, G., Bell, C., Boyce, P., Gale, C., Lampe, L., Marwat, O., Rapee, R., & Wilkins, G. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418799453 · Cited by 243
Metadata
- Authors
- Friedman, R. A.
- Affiliations
- Cornell University (US)
- Corresponding author
- Friedman, Richard A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-10-30
- Volume
- 371
- Issue
- 18
- Pages
- 1666-1668
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2006985105
- Cited by
- 171
- References
- 5
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 19 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 34 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 1
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- antidepressants, black box warning, suicide risk, FDA drug labeling, treatment underuse, depression treatment
- MeSH terms
- Suicide Prevention, Adolescent, Adult, Aged, Antidepressive Agents, Child, Depressive Disorder, Drug Labeling, Drug Utilization, Humans, Risk Factors, Suicide, United States, United States Food and Drug Administration, Government Regulation
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