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Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen
Abstract
Defects in type IV collagen, a collagenous protein involved in the formation of basement membranes, have been implicated in hereditary Alport's syndrome and acquired Goodpasture's syndrome. Mutations in genes corresponding to the building blocks of type IV collagen cause Alport's syndrome, whereas autoantibodies against structures that are usually hidden in the recesses of collagen IV cause Goodpasture's syndrome.
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Citations
Cited by
Khoshnoodi, J., Pedchenko, V., & Hudson, B. G. (2008) · Microscopy Research and Technique · doi:10.1002/jemt.20564 · Cited by 668
Self-citationRole of COL4A1 in Small-Vessel Disease and Hemorrhagic Stroke
Gould, D. B., Phalan, F. C., van Mil, S. E., Sundberg, J. P., Vahedi, K., Massin, P., Bousser, M. G., Heutink, P., Miner, J. H., Tournier-Lasserve, E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053727 · Cited by 581
The good and the bad collagens of fibrosis – Their role in signaling and organ function
Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509
McCall, A. S., Cummings, C. F., Bhave, G., Vanacore, R., Page-McCaw, A., & Hudson, B. G. (2014) · Cell · doi:10.1016/j.cell.2014.05.009 · Cited by 361
Self-citationDevelopmental and Pathogenic Mechanisms of Basement Membrane Assembly
Yurchenco, P., & Patton, B. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787846766 · Cited by 342
Metadata
- Authors
- Hudson, B. G., Tryggvason, K., Sundaramoorthy, M., & Neilson, E. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-06-19
- Volume
- 348
- Issue
- 25
- Pages
- 2543-2556
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2127923616
- Cited by
- 963
- References
- 0
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen. https://app.cochat.ai/papers/10.1056/nejmra022296
- The paper
- Hudson, B. G., Tryggvason, K., Sundaramoorthy, M., & Neilson, E. G. (2003). Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen. New England Journal of Medicine. https://doi.org/10.1056/nejmra022296
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
