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Cited by 361

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

Open access
McCall, A. Scott, Cummings, Christopher F., Bhave, Gautam, Vanacore, Roberto, Page-McCaw, Andrea, Hudson, Billy G.·2014·Cell
DOI 10.1016/j.cell.2014.05.009
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Abstract

Summary Bromine is ubiquitously present in animals as ionic bromide (Br−) yet has no known essential function. Herein, we demonstrate that Br− is a required cofactor for peroxidasin-catalyzed formation of sulfilimine crosslinks, a post-translational modification essential for tissue development and architecture found within the collagen IV scaffold of basement membranes (BMs). Bromide, converted to hypobromous acid, forms a bromosulfonium-ion intermediate that energetically selects for sulfilimine formation. Dietary Br-deficiency is lethal in Drosophila while Br-replenishment restores viability, demonstrating its physiologic requirement. Importantly, Br-deficient flies phenocopy the developmental and BM defects observed in peroxidasin mutants and indicate a functional connection between Br−, collagen IV, and peroxidasin. We establish that Br− is required for sulfilimine formation within collagen IV, an event critical for BM assembly and tissue development. Thus, bromine is an essential trace element for all animals and its deficiency may be relevant to BM alterations observed in nutritional and smoking related disease.

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Metadata

Authors
McCall, A. S., Cummings, C. F., Bhave, G., Vanacore, R., Page-McCaw, A., & Hudson, B. G.
Venue
Cell
Publisher
Elsevier BV
Published
2014-06
Volume
157
Issue
6
Pages
1380-1392
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.05.009
OpenAlex
W2167807799
Cited by
361
References
48
FWCI
9.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture. https://app.cochat.ai/papers/10.1016/j.cell.2014.05.009
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McCall, A. S., Cummings, C. F., Bhave, G., Vanacore, R., Page-McCaw, A., & Hudson, B. G. (2014). Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture. Cell. https://doi.org/10.1016/j.cell.2014.05.009

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.