Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system

A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation

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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

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Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

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Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493

Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

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Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction

Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J., & Gatlin, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030207 · Cited by 4,941

A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure

Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927

Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial

McMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604

Challenges in Treating Cardiovascular Disease: Restricting Sodium and Managing Hyperkalemia

Clegg, D. J., Cody, M., & Palmer, B. F. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.04.006 · Cited by 14

A Model to Predict Risk of Hyperkalemia in Patients with Chronic Kidney Disease Using a Large Administrative Claims Database

Sharma, A. K., Alvarez, P. J., Woods, S. D., & Dai, D. (2020) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s267063 · Cited by 12

Sorbets as Functional Food Products, Unexplored Food Matrices, Their Challenges, and Advancements

Williams, J., McKune, A. J., & Naumovski, N. (2023) · Applied Sciences · doi:10.3390/app132111945 · Cited by 12

A Survey of Nursing Home Physicians to Determine Laboratory Monitoring Adverse Drug Event Alert Preferences

Perera, S., Nace, D. A., Culley, C. M., Handler, S. M., & Boyce, R. D. (2014) · Applied Clinical Informatics · doi:10.4338/aci-2014-06-ra-0053 · Cited by 11

Patiromer Facilitates Angiotensin Inhibitor and Mineralocorticoid Antagonist Therapies in Patients With Heart Failure and Hyperkalemia

Pitt, B., Anker, S. D., Lund, L. H., Coats, A. J. S., Filippatos, G. S., Rossignol, P., Weir, M. R., Friede, T., Kosiborod, M., Metra, M., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.05.079 · Cited by 11

Sodium Zirconium Cyclosilicate

Levien, T. L., & Baker, D. E. (2018) · Hospital Pharmacy · doi:10.1177/0018578718817470 · Cited by 11

Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia

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The target‐specific transporter and current status of diuretics as antihypertensive

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Racial Differences in Potassium Response to Spironolactone in Heart Failure

Cavallari, L. H., Groo, V. L., Momary, K. M., Fontana, D., Viana, M. A. G., & Vaitkus, P. T. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2006.05502.x · Cited by 11

An Economic Evaluation of a Laboratory Monitoring Program for Renin-Angiotensin System Agents

Smith, D. H., Raebel, M. A., Chan, K. A., Johnson, E. S., Petrik, A. F., Weiss, J. R., Yang, X., & Feldstein, A. C. (2011) · Medical Decision Making · doi:10.1177/0272989x10379918 · Cited by 11

Preventing end-stage renal disease: flexible strategies to overcome obstacles

Hirsch, S. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000242171.29329.1d · Cited by 11

Hyperkalemia in Predialysis Patients

Palmer, B. F. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06060612 · Cited by 11

Risk–Benefit Balance of Renin–Angiotensin–Aldosterone Inhibitor Cessation in Heart Failure Patients with Hyperkalemia

Kohsaka, S., Okami, S., Morita, N., & Yajima, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195828 · Cited by 10

New Onset of Diabetes Mellitus and Associated Factors among COVID-19 Patients in COVID-19 Care Centers, Addis Ababa, Ethiopia 2022

Habtamu, A., Sibhat, M. M., Getnet, M., Zewde, W. C., Mesfin, E. G., Beyene, H. A., Ashine, T. M., Tiruneh, K. G., & Mengistie, M. A. (2022) · Journal of Diabetes Research · doi:10.1155/2022/9652940 · Cited by 10

Hyperkalemia by eplerenone or esaxerenone in the presence or absence of clarithromycin in hypertensive patients: a retrospective observational cohort study

Hirai, T., Ueda, S., Ogura, T., Katayama, K., Dohi, K., Hosohata, K., Aoyama, T., Matsumoto, Y., & Iwamoto, T. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003372 · Cited by 10

Acid base and fluid electrolyte disturbances in Chronic Kidney Disease

Mahaldar, A. R. (2012) · Clinical Queries Nephrology · doi:10.1016/j.cqn.2012.09.003 · Cited by 10

Outcomes in patients with cardiometabolic disease who develop hyperkalemia while treated with a renin-angiotensin-aldosterone system inhibitor

Johnson, M., Morrison, F. J. R., McMahon, G. M., Su, M., & Turchin, A. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.01.002 · Cited by 10

Role of Sodium Restriction and Diuretic Therapy for “Resistant” Hypertension in Chronic Kidney Disease

Sinnakirouchenan, R., & Kotchen, T. A. (2014) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2014.08.005 · Cited by 10

Hyperkalemia associated with spironolactone therapy.

Dolovich, L. R., Gavura, S., & Pottie, K. C. (2005) · Europe PMC (PubMed Central) · Cited by 10

Cardio-renal failure: an emerging clinical entity

Gil, P., Justo, S., & Caramelo, C. A. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh927 · Cited by 10

Is there a pharmacologic basis for combination renin axis blockade?

Hollenberg, N. K. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00773.x · Cited by 10

The Role of the Multidisciplinary Team

So, W., & Chan, J. C. N. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch57 · Cited by 10

Inappropriate medication prescribing, polypharmacy, potential drug-drug interactions and medication regimen complexity in older adults attending three referral hospitals in Asmara, Eritrea: a cross-sectional study

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The positive predictive value of a hyperkalemia diagnosis in automated health care data

Raebel, M. A., Smith, M. L., Saylor, G., Wright, L., Cheetham, C., Blanchette, C. M., & Xu, S. (2010) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2030 · Cited by 9

Expanding Role of Mineralocorticoid Receptor Antagonists in the Treatment of Heart Failure

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Hyperkalemia and Electrocardiogram Manifestations in End-Stage Renal Disease

Rafique, Z., Hoang, B., Mesbah, H., Pappal, R. D., Peacock, W. F., Juárez‐Vela, R., Szarpak, Ł., & Kuo, D. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192316140 · Cited by 9

Dose- and time-dependent renoprotection of Angelica sinensis in patients with chronic kidney disease: A longitudinal cohort study

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The Prevalence and Risk Factors of Hyperkalemia in the Outpatient Setting

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Cardiac Medications Are Not Associated with Clinically Important Preoperative Electrolyte Disturbances in Children Presenting for Cardiac Surgery

Hastings, L. A., Wood, J. C., Harris, B. D., Busse, S. V., Drachenberg, A., Dorey, F. J., & Bushman, G. A. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318189adcf · Cited by 9

Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome

Ueno, H., Yoshimura, M., Nakayama, M., Yamamuro, M., Nishijima, T., Kusuhara, K., Nagayoshi, Y., Kojima, S., Kaikita, K., Sumida, H., et al. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.08.011 · Cited by 9

Emerging therapies for the management of chronic hyperkalemia in the ambulatory care setting

Henneman, A., Guirguis, E. H., Grace, Y., Patel, D., & Shah, B. (2015) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp150457 · Cited by 9

A Stepped Care Approach to the Management of Chronic Kidney Disease

Fogarty, D. G., & Taal, M. W. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6193-9.10061-2 · Cited by 9

Role of Single‐Pill Combination Therapy in Optimizing Blood Pressure Control in High‐Risk Hypertension Patients and Management of Treatment‐Related Adverse Events

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Can we prevent or treat renal dysfunction in chronic heart failure?

Dobre, D., Rossignol, P., Metra, M., & Zannad, F. M. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9264-0 · Cited by 9

The role of aldosterone receptor antagonists in the management of heart failure: An update

Nagarajan, V., Chamsi‐Pasha, M. A., & Tang, W. H. W. (2012) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.79a.12014 · Cited by 9

Hyperkalemia in heart failure patients: current challenges and future prospects

Bonet, L. A., López‐Vilella, R., Climent, H. M., López, D. P., Sánchez-Lázaro, I. J., & Pinar, M. C. (2016) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s75680 · Cited by 9

Role of Hyperkalemia in Heart Failure and the Therapeutic Use of Potassium Binders

Sarwar, C. M. S., Bhagat, A. A., Anker, S. D., & Butler, J. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_25 · Cited by 9

The impact of chronic kidney disease on medication choice and pharmacologic management in patients with heart failure

Shah, S. R., & Winchester, D. E. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1479252 · Cited by 9

Syncope caused by iatrogenic hyperkalemia

Giancaspro, G., Suppa, M., Genuini, I., Caselli, S., & Fedele, F. G. (2009) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e328319bfa4 · Cited by 9

Monitoring renal function in hypertension

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An update on proteinuric chronic kidney disease: The dual-goal approach

HIRSCH, S. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.10.705 · Cited by 9

Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Might Be Associated with Lung Adenocarcinoma Risk: A Nationwide Population-Based Nested Case–Control StudyPreprint

Hsu, H. L., Lee, C., Zhang, J.-F., & Wu, S. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3564398 · Cited by 9

Managing Hyperkalemia to Enable Guideline-Recommended Dosing of Renin-Angiotensin-Aldosterone System Inhibitors

Palmer, B. F., & Clegg, D. J. (2022) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2022.02.012 · Cited by 9

Predicting Weight Loss Success After Gastric Sleeve Surgery: A Machine Learning-Based Approach

Domínguez, M. C., Montano, I. H., Gómez, J. J. L., Bachiller, B. R., de Luis, D. A., & Díez, I. D. L. T. (2025) · Nutrients · doi:10.3390/nu17081391 · Cited by 8

Approved Steroidal Drugs (2000–2025): A Medicinal Chemistry Perspective

Zhu, J., Luo, G., & Xiang, H. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03005 · Cited by 8

Impact of hyperkalaemia definition on incidence assessment: implications for epidemiological research based on a large cohort study in newly diagnosed heart failure patients in primary care

Martín‐Pérez, M., Ruigómez, A., Michel, A., & Rodríguez, L. A. G. (2016) · BMC Family Practice · doi:10.1186/s12875-016-0448-5 · Cited by 8

Patiromer

Vu, B. N., Castro, A. M. D., Shottland, D., Frishman, W. H., & Cheng-Lai, A. (2016) · Cardiology in Review · doi:10.1097/crd.0000000000000123 · Cited by 8

Efficacy and safety of calcium polystyrene sulfonate in patients with hyperkalemia and stage 3–5 non-dialysis chronic kidney disease: a single-center randomized controlled trial

Wang, X., Chen, D., Song, X., Wang, J., & Zhang, H. (2023) · Journal of International Medical Research · doi:10.1177/03000605231167516 · Cited by 8

Efficacy and safety of delapril/indapamide compared to different ACE-inhibitor/hydrochlorothiazide combinations: a meta-analysis

Circelli, M., Nicolini, Egan, C. G., & Cremonesi (2012) · International Journal of General Medicine · doi:10.2147/ijgm.s35220 · Cited by 8

Healthcare utilization and expenditures associated with hyperkalemia management: a retrospective study of Medicare Advantage patients

Desai, N. R., Alvarez, P. J., Golestaneh, L., Woods, S. D., Coca, S. G., & Rowan, C. G. (2021) · Journal of Medical Economics · doi:10.1080/13696998.2021.1965389 · Cited by 8

Management of Hyperkalemia in Heart Failure

Altay, H., Çavuşoğlu, Y., Çelik, A., Demir, Ş., Adana Devlet Hastanesi, K. K., Kılıçarslan, B., Tepecik Egitim ve Arastirma Hastanesi, K. K., Nalbantgil, S., Temizhan, A., Tokgöz, B., et al. (2021) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2021.s1 · Cited by 8

Preclinical safety evaluation of calcineurin inhibitors delivered through an intraductal route to prevent post-ERCP pancreatitis demonstrates endocrine and systemic safety

Ni, J., Khalid, A., Lin, Y.-C., Barakat, M. T., Wang, J., Tsai, C., Azar, P. R. S., Ding, Y., Murayi, J. O., Jayaraman, T., et al. (2023) · Pancreatology · doi:10.1016/j.pan.2023.03.009 · Cited by 8

Renal Complications in Oncohematologic Patients

Buemi, M., Fazio, M. R., Bolignano, D., Coppolino, G., Donato, V., Lacquaniti, A., Mondello, S., Buemi, A., & Allegra, A. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181c5e762 · Cited by 8

Heart failure in subjects with chronic kidney disease: Best management practices

Aslam, F. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i5.112 · Cited by 8

Pharmacologic therapy in patients with chronic heart failure and chronic kidney disease: a complex issue

Acquarone, N., Castello, C., Antonucci, G., Lione, S., & Bellotti, P. (2009) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3283189533 · Cited by 8

What is the risk of hyperkalaemia in heart failure?

Bielecka-Dabrowa, A. M., Rysz, J., Mikhailidis, D. P., & Banach, M. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.601743 · Cited by 8

Effects of Dual Blockade of the Renin Angiotensin System in Diabetic Kidney Disease: A Systematic Review and Meta-Analysis

Pham, J. T. (2012) · Journal of Nephrology & Therapeutics · doi:10.4172/2161-0959.s2-003 · Cited by 8

Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions

Choi, J. Y., Cho, S. G., Jang, K.-S., & Kim, G. (2020) · Electrolytes & Blood Pressure · doi:10.5049/ebp.2020.18.1.10 · Cited by 8

Optimizing Therapies in Heart Failure: The Role of Potassium Binders

Scicchitano, P., Iacoviello, M., Massari, F., Palo, M. D., Caldarola, P., Mannarini, A., Passantino, A., Ciccone, M. M., & Magnesa, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071721 · Cited by 8

New treatments for hyperkalaemia: clinical use in cardiology

Vijayakumar, S., Butler, J., & Anker, S. D. (2019) · European Heart Journal Supplements · doi:10.1093/eurheartj/suy031 · Cited by 8

Effects of pharmacist participation in chronic kidney disease (CKD) network and CKD manual distribution on drug‐related kidney injury

Yamamoto, T., Nakayama, I., Kawakatsu, Y., Yamamoto, T., Ishigami, N., Watanuki, K., Okabe, T., & Yokoyama, H. (2019) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4787 · Cited by 8

Untoward effects of chronic dual renin-angiotensin system blockade: influence of previous chronic renal failure

Robles, N. R., Cancho, B., Barroso, S., Martín, M. V. M., & Casado, E. S. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.00995.x · Cited by 8

Life threatening severe hyperkalemia presenting typical electrocardiographic changes—Rapid recovery following medical, temporary pacing, and hemodialysis treatments

Oh, P. C., Koh, K. K., Kim, J. H., Park, H., & Kim, S. J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.09.069 · Cited by 8

Study of the use of a spironolactone and angiotensin‐converting enzyme inhibitor combination: a population‐based analysis

Besançon, J., Lagarce, L., Diquet, B., & Lainé‐Cessac, P. (2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1511 · Cited by 8

Acute hyperkalemia in adults

Emektar, E. (2023) · Turkish Journal of Emergency Medicine · doi:10.4103/tjem.tjem_288_22 · Cited by 7

Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice

Khan, L. A., Jamil, A., Greene, S. J., Khan, M. S., & Butler, J. (2024) · Cardiac failure review · doi:10.15420/cfr.2024.09 · Cited by 7

Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats

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Potassium binding for conservative and preservative management of chronic kidney disease

Clegg, D. J., & Palmer, B. F. (2019) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000564 · Cited by 7

Effect of patiromer on serum potassium in hyperkalemic patients with heart failure: Pooled analysis of 3 randomized trials

Piña, I. L., Yuan, J., Ackourey, G., & Ventura, H. O. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.09.007 · Cited by 7

Hyperkalemia Management in Older Adults With Diabetic Kidney Disease Receiving Renin-Angiotensin-Aldosterone System Inhibitors: A Post Hoc Analysis of the AMETHYST-DN Clinical Trial

Bakris, G. L., Woods, S. D., Alvarez, P. J., Arthur, S. P., & Kumar, R. (2021) · Kidney Medicine · doi:10.1016/j.xkme.2021.01.005 · Cited by 7

Long-term Patiromer Use and Outcomes Among US Veterans With Hyperkalemia and CKD: A Propensity-Matched Cohort Study

Obi, Y., Thomas, F., Dashputre, A. A., Goedecke, P. J., & Kovesdy, C. P. (2023) · Kidney Medicine · doi:10.1016/j.xkme.2023.100757 · Cited by 7

Evolving strategies for the use of spironolactone in cardiovascular disease

Jolobe, O. M. P. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.11.007 · Cited by 7

Patiromer for Heart Failure Medication Optimization in Patients With Current or Past Hyperkalemia

Coats, A. J. S., Anker, S. D., Lund, L. H., Filippatos, G., Rossignol, P., Pitt, B., Weir, M. R., Kosiborod, M., Metra, M., Böhm, M., et al. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.08.003 · Cited by 6

Pharmacology and Therapeutic Potential of Finerenone: A Novel Third-Generation Nonsteroidal Mineralocorticoid Receptor Antagonist

Ramadan, M. M., Alajmi, S., Aldouseri, J., Alajmi, M., Tello, E., Mahdi, A.-M. O., Aladwani, A. J., AlAyyaf, A. E., Mahdi, O., & Elmahal, M. (2025) · Cureus · doi:10.7759/cureus.87706 · Cited by 6

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Adomako, E. A., & Maalouf, N. M. (2022) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000859 · Cited by 6

Aging and Remodeling of the RAS and RAAS and Related Pathways: Implications for Heart Failure Therapy

Jugdutt, B. I. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_18 · Cited by 6

Assessment of Renal Function, Iatrogenic Hyperkalemia and Acute Renal Dysfunction in Cardiology. Contrast-Induced Nephropathy

Teruel, J. L., & Catalán, S. B. (2011) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2011.08.012 · Cited by 6

Expression, purification and thermal stability evaluation of an engineered amaranth protein expressed in Escherichia coli

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Development of hyperkalemia following treatment with dapagliflozin (DAPA) in a patient with type 2 diabetes after bilateral adrenalectomy

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Early Detection of Cardiovascular Disease in Patients with Chronic Kidney Disease using Data Mining Techniques

Chaudhuri, A. K., Ray, A., Das, A., Chakrabarti, P., & Banerjee, D. K. (2020) · ASIAN JOURNAL OF CONVERGENCE IN TECHNOLOGY · doi:10.33130/ajct.2020v06i03.011 · Cited by 6

Association of serum potassium with decline in residual kidney function in incident hemodialysis patients

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