Cited by 230Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsChromatin Remodeling and Cancer

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Chromosomal Abnormalities in Cancer

Fröhling, Stefan, Döhner, Hartmut·2008·New England Journal of Medicine

DOI 10.1056/nejmra0803109

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Abstract

This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–small-cell lung cancer. The authors point out that some of the chromosomal abnormalities have revealed targets for cancer treatment, and others have clinical application in the diagnosis of certain types of neoplasms and in the formulation of a prognosis.

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Authors: Fröhling, S., & Döhner, H.
Affiliations: Brigham and Women's Hospital (US)
University Hospital Ulm (DE)
ORCID: Fröhling, Stefan
Döhner, Hartmut
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-08-14
Volume: 359
Issue: 7
Pages: 722-734
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra0803109
OpenAlex: W1975410130
Cited by: 229
References: 94
Citations by year: 2025: 8 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 19 · 2012: 18
FWCI: 2.39
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: chromosomal abnormalities, cancer, hematologic malignancies, solid tumors, prostate cancer, non-small cell lung cancer, cancer therapy targets, tumor diagnosis, prognosis
MeSH terms: Chromosome Aberrations, Chromosomes, Human, Humans, Neoplasms, Protein-Tyrosine Kinases, Transcription Factors, Translocation, Genetic, Gene Expression Regulation, Neoplastic

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