The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Chromosomal Abnormalities in Cancer
Abstract
This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–small-cell lung cancer. The authors point out that some of the chromosomal abnormalities have revealed targets for cancer treatment, and others have clinical application in the diagnosis of certain types of neoplasms and in the formulation of a prognosis.
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“Chromosomal translocations are very common in hematologic malignancies [200, 201].”
From Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies (2020) · cites this paper as [201]
Citations
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- Nowell PC, 1960, J Natl Cancer Inst, 25, 85
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Metadata
- Authors
- Fröhling, S., & Döhner, H.
- Affiliations
- Brigham and Women's Hospital (US)
- University Hospital Ulm (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-08-14
- Volume
- 359
- Issue
- 7
- Pages
- 722-734
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1975410130
- Cited by
- 229
- References
- 94
- Citations by year
- 2025: 8 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 19 · 2012: 18
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromosomal abnormalities, cancer, hematologic malignancies, solid tumors, prostate cancer, non-small cell lung cancer, cancer therapy targets, tumor diagnosis, prognosis
- MeSH terms
- Chromosome Aberrations, Chromosomes, Human, Humans, Neoplasms, Protein-Tyrosine Kinases, Transcription Factors, Translocation, Genetic, Gene Expression Regulation, Neoplastic
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