Cited by 317Breast Cancer Treatment StudiesAdvanced Breast Cancer TherapiesEstrogen and related hormone effects

Systemic Therapy for Estrogen Receptor–Positive, HER2-Negative Breast Cancer

Burstein, Harold J.·2020·New England Journal of Medicine

Abstract

ER-positive, HER2-negative breast cancer, which accounts for about 70% of all breast cancers, is heterogeneous. Antiestrogen therapy is the cornerstone of systemic therapy, and its efficacy depends on such factors as grade, Ki-67 labeling, and progesterone receptor expression.

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Crossref · 10.1056/nejmra1307118

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  • CDK4/6 inhibitors are effective in the treatment of some cancers, particularly oestrogen receptor-positive breast cancers.

    “CDK4/6 inhibitors, such as palbociclib, ribociclib and abemaciclib, are effective in the treatment of some cancers, particularly oestrogen receptor-positive breast cancers147.”

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Authors
Burstein, H. J.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Burstein, Harold J.
Venue
New England Journal of Medicine
Published
2020-12-24
Volume
383
Issue
26
Pages
2557-2570
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W3116128628
Cited by
316
References
106
Citations by year
2026: 51 · 2025: 53 · 2024: 67 · 2023: 62 · 2022: 53 · 2021: 30
FWCI
3.70
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Advanced Breast Cancer Therapies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
estrogen receptor-positive breast cancer, HER2-negative breast cancer, systemic therapy, antiestrogen therapy, breast cancer heterogeneity, progesterone receptor expression, tumor grade
MeSH terms
Breast Neoplasms, Female, Humans, Prognosis, Receptors, Estrogen, Chemotherapy, Adjuvant, Erb-b2 Receptor Tyrosine Kinases, Receptor, ErbB-2, Neoadjuvant Therapy, Selective Estrogen Receptor Modulators, Estrogen Receptor Antagonists

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