Myeloproliferative Neoplasms
Abstract
The myeloproliferative disorders, comprising polycythemia vera, essential thrombocytosis, and myelofibrosis, are clonal hematopoietic cancers that have an indolent course. The clinical manifestations of these entities overlap, as do their genetic drivers.
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These cytokines display overlapping features, such as inducing cell cycle entry of HSCs and their differentiation, frequently toward the granulo-monocytic lineage.
“These cytokines display overlapping features, such as inducing cell cycle entry of HSCs and their differentiation, frequently toward the granulo-monocytic lineage 1,4-6,12-15 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [14]
Cites
Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>
Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756 · see citing works
CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress
Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., van Rooijen, N., et al. (2013) · Nature Medicine · doi:10.1038/nm.3057 · Cited by 433 · see citing works
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Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms
Fisher, D. A. C., Fowles, J. S., Zhou, A., & Oh, S. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683401 · Cited by 115 · see citing works
Type 1 interferon perturbates clonal competition by reshaping human blood development
Lama, C., Isakov, D., Rosenberg, S., Quijada-Álamo, M., Saurty-Seerunghen, M. S., Moein, S., Nozais, M., Abera, T.-A., Sakaguchi, O., Totwani, M., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02751-3 · Cited by 3 · see citing works
- Authors
- Spivak, J. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Spivak, Jerry L.
- ORCID
- Spivak, Jerry L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-06
- Volume
- 376
- Issue
- 22
- Pages
- 2168-2181
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4249369999
- Cited by
- 404
- References
- 2
- Citations by year
- 2026: 31 · 2025: 35 · 2024: 37 · 2023: 46 · 2022: 50 · 2021: 70 · 2020: 56 · 2019: 40 · 2018: 27 · 2017: 12
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, myelofibrosis, indolent disease, driver genes, clinical features
- MeSH terms
- Age Factors, Antineoplastic Agents, Female, Hematopoietic Stem Cells, Humans, Male, Mutation, Myeloproliferative Disorders, Phenotype, Polycythemia Vera, Sex Factors, Thrombocythemia, Essential, Leukemia, Myeloid, Acute, Gene Expression, Bone Marrow Transplantation, Primary Myelofibrosis
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