CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress
Open accessAbstract
A role for macrophages in erythropoiesis was suggested several decades ago when erythroblastic islands in the bone marrow, composed of a central macrophage surrounded by developing erythroblasts, were described. However, the in vivo role of macrophages in erythropoiesis under homeostatic conditions or in disease remains unclear. We found that specific depletion of CD169(+) macrophages markedly reduced the number of erythroblasts in the bone marrow but did not result in overt anemia under homeostatic conditions, probably because of concomitant alterations in red blood cell clearance. However, CD169(+) macrophage depletion significantly impaired erythropoietic recovery from hemolytic anemia, acute blood loss and myeloablation. Furthermore, macrophage depletion normalized the erythroid compartment in a JAK2(V617F)-driven mouse model of polycythemia vera, suggesting that erythropoiesis in polycythemia vera remains under the control of macrophages in the bone marrow and splenic microenvironments. These results indicate that CD169(+) macrophages promote late erythroid maturation and that modulation of the macrophage compartment may be a new strategy to treat erythropoietic disorders.
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The major source of iron for systemic needs, such as red blood cell maturation, are macrophages, which ingest senescent erythrocytes as well as haptoglobin-bound free hemoglobin and heme/Fe complexes released from lysed red blood cells.
“However, the major source of iron for systemic needs, such as red blood cell (RBC) maturation, are macrophages, which ingest senescent erythrocytes as well as haptoglobin-bound free hemoglobin and heme/Fe complexes released from lysed RBCs (Burger et al., 2012; Chow et al., 2013).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Chow et al., 2013
A moderate decrease of iron supply to erythroblasts as deduced from reduced Hb content in reticulocytes was observed after EIM depletion.
“Concretely, a moderate decrease of iron supply to erythroblasts as deduced from the reduced Hb content in reticulocytes was observed [38].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [38]
Depletion of EIM (and other CD169+ macrophages) had only little impact on the restoration of erythropoiesis after bone marrow transplantation.
“Data in support of this concept has been generated using the CD169-DTR model: The depletion of EIM (and other CD169+ macrophages) had only little impact on the restoration of erythropoiesis after BM transplantation.”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [38]
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- Authors
- Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., van Rooijen, N., Tanaka, M., Zhao, Z. J., Bergman, A., Merad, M., & Frenette, P. S.
- Affiliations
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
- Institut Pasteur (FR)
- Tokyo University of Pharmacy and Life Sciences (JP)
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Frenette, Paul S
- ORCID
- Venue
- Nature Medicine
- Published
- 2013-03-17
- Volume
- 19
- Issue
- 4
- Pages
- 429-436
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3983996
- OpenAlex
- W2066005598
- Semantic Scholar
- d9d50bd98a92c9991c1b66c7664adaf3d4dd5f5a
- Cited by
- 433
- References
- 47
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 27 · 2021: 44 · 2020: 42 · 2019: 38 · 2018: 32 · 2017: 40 · 2016: 35 · 2015: 35 · 2014: 44 · 2013: 12
- FWCI
- 30.13
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (23390095)
- National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, F30HL099028, R01HL069438, R01HL097819)
- National Cancer Institute (R01CA112100)
- National Institute of General Medical Sciences (T32GM062754)
- National Institute of Allergy and Infectious Diseases (U01AI095611)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Keywords
- CD169+ macrophages, erythropoiesis, erythroblasts, erythroid maturation, polycythemia vera, JAK2 V617F mutation, macrophage depletion, hemolytic anemia, acute blood loss, myeloablation, red blood cell clearance, bone marrow microenvironment, splenic microenvironment
- MeSH terms
- Anemia, Anemia, Hemolytic, Animals, Erythroblasts, Erythropoiesis, Female, Homeostasis, Humans, Macrophages, Male, Mice, Inbred C57BL, Polycythemia Vera, Spleen, Stress, Physiological, Vascular Cell Adhesion Molecule-1, Mice, Sialic Acid Binding Ig-like Lectin 1
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