Anemia of Inflammation
Abstract
Anemia of inflammation is a common normocytic, normochromic anemia associated with systemic inflammation that increases the level of hepcidin and results in defective iron reuse from body stores. Reducing inflammation can help correct the defect.
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In functional iron deficiency (e.g., in inflammation) total body iron is not decreased, but iron is sequestered in stores by the high hepcidin levels.
“In functional iron deficiency (e.g., in inflammation) total body iron is not decreased, but iron is sequestered in stores by the high hepcidin levels.84,97”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [97]
Targeting the hepcidin-ferroportin axis may not fully correct anemia of inflammation, which is multifactorial and characterized by low erythropoietin and a blunted erythropoietic response.
“However, targeting the hepcidin-ferroportin axis may not fully correct this multifactorial anemia characterized by low erythropoietin and a blunted erythropoietic response.97,98”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [97]
Proinflammatory cytokines such as IL-6 and IL-1β, produced in chronic infections, autoimmunity, cancer, renal failure and other chronic disorders, activate hepcidin expression leading to iron-restricted erythropoiesis and anemia of inflammation.
“Proinflammatory cytokines such as IL-6 and IL-1β, produced in chronic infections, autoimmunity, cancer, renal failure and other chronic disorders activate hepcidin expression leading to iron-restricted erythropoiesis and anemia of inflammation, once named anemia of chronic diseases.84,97,98”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [97]
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Cites
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Anemia at older age: etiologies, clinical implications, and management
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Self-citationA mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
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Iron metabolism and iron disorders revisited in the hepcidin era
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Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis
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Self-citationAberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
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The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
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Effects of PM2.5 and its constituents on hemoglobin during the third trimester in pregnant women
Xie, G., Yue, J., Yang, W., Yang, L., Xu, M., Sun, L., Zhang, B., Guo, L., & Chung, M. C. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-18693-2 · Cited by 34 · see citing works
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- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2019-09-19
- Volume
- 381
- Issue
- 12
- Pages
- 1148-1157
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2973305257
- Cited by
- 589
- References
- 11
- Citations by year
- 2026: 74 · 2025: 102 · 2024: 98 · 2023: 89 · 2022: 76 · 2021: 86 · 2020: 59 · 2019: 3
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- anemia of chronic disease, hepcidin, iron metabolism, systemic inflammation, normocytic normochromic anemia, iron stores, inflammation reduction
- MeSH terms
- Anemia, Hemoglobins, Humans, Inflammation, Iron, Biomarkers
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