Drug-induced liver injury—types and phenotypes
Abstract
The liver has a range of responses to drug-induced injury, with a number of phenotypes. In addition, idiosyncratic reactions may occur as a consequence of both direct drug action and indirect drug effects. Antibiotics are the most common cause of drug-induced liver injury.
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Sulfamethoxazole (SMX) is associated with idiosyncratic drug-induced liver injury (DILI) that is difficult to predict.
“Sulfamethoxazole (SMX) is associated with idiosyncratic drug induced liver injury (DILI), which remains difficult to predict.”
From N-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation (2025) · cites this paper as [2]
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- Authors
- Hoofnagle, J. H., & Björnsson, E. S.
- Affiliations
- National Institutes of Health (US)
- From the Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (J.H.H.); and the Department of Internal Medicine, National University Hospital of Iceland, and the Faculty of Medicine, University of Iceland — both in Reykjavík (E.S.B.).
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2019-07-18
- Volume
- 381
- Issue
- 3
- Pages
- 264-273
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2960526624
- Cited by
- 652
- References
- 72
- Citations by year
- 2026: 57 · 2025: 101 · 2024: 98 · 2023: 108 · 2022: 107 · 2021: 111 · 2020: 54 · 2019: 15
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- drug-induced liver injury, idiosyncratic drug reactions, antibiotics
- MeSH terms
- Anti-Bacterial Agents, Humans, Liver, Phenotype, Dietary Supplements, Plant Preparations, Prescription Drugs, Chemical and Drug Induced Liver Injury
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