Cited by 652Drug-Induced Hepatotoxicity and ProtectionPharmacovigilance and Adverse Drug ReactionsDrug-Induced Adverse Reactions

Drug-induced liver injury—types and phenotypes

Hoofnagle, Jay H., Björnsson, Einar S.·2019·New England Journal of Medicine

Abstract

The liver has a range of responses to drug-induced injury, with a number of phenotypes. In addition, idiosyncratic reactions may occur as a consequence of both direct drug action and indirect drug effects. Antibiotics are the most common cause of drug-induced liver injury.

Integrity signals

Registry

Crossref · 10.1056/nejmra1816149

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hoofnagle, J. H., & Björnsson, E. S.
Affiliations
  • National Institutes of Health (US)
  • From the Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (J.H.H.); and the Department of Internal Medicine, National University Hospital of Iceland, and the Faculty of Medicine, University of Iceland — both in Reykjavík (E.S.B.).
Venue
New England Journal of Medicine
Published
2019-07-18
Volume
381
Issue
3
Pages
264-273
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2960526624
Cited by
652
References
72
Citations by year
2026: 57 · 2025: 101 · 2024: 98 · 2023: 108 · 2022: 107 · 2021: 111 · 2020: 54 · 2019: 15
FWCI
11.37
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Hirsla (Landspítali University Hospital) (submittedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
Keywords
drug-induced liver injury, idiosyncratic drug reactions, antibiotics
MeSH terms
Anti-Bacterial Agents, Humans, Liver, Phenotype, Dietary Supplements, Plant Preparations, Prescription Drugs, Chemical and Drug Induced Liver Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review