CoChat
Sign Up
Cited by 502Complementary and Alternative Medicine StudiesPharmacovigilance and Adverse Drug ReactionsNutrition and Health Studies

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Emergency Department Visits for Adverse Events Related to Dietary Supplements

Open access
Geller, Andrew I., Shehab, Nadine, Weidle, Nina J., Lovegrove, Maribeth C., Wolpert, Beverly J., Timbo, Babgaleh B., Mozersky, Robert P., Budnitz, Daniel S.·2015·New England Journal of Medicine
DOI 10.1056/nejmsa1504267PMC PMC6196363
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Dietary supplements, such as herbal or complementary nutritional products and micronutrients (vitamins and minerals), are commonly used in the United States, yet national data on adverse effects are limited. METHODS: We used nationally representative surveillance data from 63 emergency departments obtained from 2004 through 2013 to describe visits to U.S. emergency departments because of adverse events related to dietary supplements. RESULTS: On the basis of 3667 cases, we estimated that 23,005 (95% confidence interval [CI], 18,611 to 27,398) emergency department visits per year were attributed to adverse events related to dietary supplements. These visits resulted in an estimated 2154 hospitalizations (95% CI, 1342 to 2967) annually. Such visits frequently involved young adults between the ages of 20 and 34 years (28.0% of visits; 95% CI, 25.1 to 30.8) and unsupervised children (21.2% of visits; 95% CI, 18.4 to 24.0). After the exclusion of unsupervised ingestion of dietary supplements by children, 65.9% (95% CI, 63.2 to 68.5) of emergency department visits for single-supplement-related adverse events involved herbal or complementary nutritional products; 31.8% (95% CI, 29.2 to 34.3) involved micronutrients. Herbal or complementary nutritional products for weight loss (25.5%; 95% CI, 23.1 to 27.9) and increased energy (10.0%; 95% CI, 8.0 to 11.9) were commonly implicated. Weight-loss or energy products caused 71.8% (95% CI, 67.6 to 76.1) of supplement-related adverse events involving palpitations, chest pain, or tachycardia, and 58.0% (95% CI, 52.2 to 63.7) involved persons 20 to 34 years of age. Among adults 65 years of age or older, choking or pill-induced dysphagia or globus caused 37.6% (95% CI, 29.1 to 46.2) of all emergency department visits for supplement-related adverse events; micronutrients were implicated in 83.1% (95% CI, 73.3 to 92.9) of these visits. CONCLUSIONS: An estimated 23,000 emergency department visits in the United States every year are attributed to adverse events related to dietary supplements. Such visits commonly involve cardiovascular manifestations from weight-loss or energy products among young adults and swallowing problems, often associated with micronutrients, among older adults. (Funded by the Department of Health and Human Services.).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejmsa1504267

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 22 references

Research works printed but not linked: 3

  1. Nahin RL, Natl Health Stat Report, 2009, 1
  2. Harel Z, 2013, JAMA Intern Med, 173, 926
  3. 10.4065/74.5.443 · DOI · Paper page

Cited by

Sorted by citations

Items 301–400 of 499

Related

See all

Metadata

Authors
Geller, A. I., Shehab, N., Weidle, N. J., Lovegrove, M. C., Wolpert, B. J., Timbo, B. B., Mozersky, R. P., & Budnitz, D. S.
Affiliations
  • Center for Food Safety and Applied Nutrition (US)
  • Centers for Disease Control and Prevention (US)
  • United States Food and Drug Administration (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2015-10-15
Volume
373
Issue
16
Pages
1531-1540
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmsa1504267
PMC
PMC6196363
OpenAlex
W2330664058
Cited by
502
References
22
Citations by year
2026: 35 · 2025: 44 · 2024: 41 · 2023: 46 · 2022: 50 · 2021: 45 · 2020: 58 · 2019: 40 · 2018: 47 · 2017: 48 · 2016: 43 · 2015: 5
FWCI
93.54
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Health and Human Services
  • U.S. Consumer Product Safety Commission
  • National Institutes of Health (CC999999)
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
dietary supplements, emergency department visits, micronutrients, weight loss supplements, energy supplements, hospitalization, choking, dysphagia, tachycardia, emergency department surveillance, young adults, older adults, supplement safety
MeSH terms
Adolescent, Adult, Aged, Complementary Therapies, Calcium, Child, Child, Preschool, Emergency Service, Hospital, Female, Hospitalization, Humans, Iron, Phytotherapy, Middle Aged, Population Surveillance, Potassium, United States, Age Distribution, Micronutrients, Dietary Supplements, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review