Cited by 502Complementary and Alternative Medicine StudiesPharmacovigilance and Adverse Drug ReactionsNutrition and Health Studies

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Emergency Department Visits for Adverse Events Related to Dietary Supplements

Open access

Geller, Andrew I., Shehab, Nadine, Weidle, Nina J., Lovegrove, Maribeth C., Wolpert, Beverly J., Timbo, Babgaleh B., Mozersky, Robert P., Budnitz, Daniel S.·2015·New England Journal of Medicine

DOI 10.1056/nejmsa1504267PMC PMC6196363

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Dietary supplements, such as herbal or complementary nutritional products and micronutrients (vitamins and minerals), are commonly used in the United States, yet national data on adverse effects are limited. METHODS: We used nationally representative surveillance data from 63 emergency departments obtained from 2004 through 2013 to describe visits to U.S. emergency departments because of adverse events related to dietary supplements. RESULTS: On the basis of 3667 cases, we estimated that 23,005 (95% confidence interval [CI], 18,611 to 27,398) emergency department visits per year were attributed to adverse events related to dietary supplements. These visits resulted in an estimated 2154 hospitalizations (95% CI, 1342 to 2967) annually. Such visits frequently involved young adults between the ages of 20 and 34 years (28.0% of visits; 95% CI, 25.1 to 30.8) and unsupervised children (21.2% of visits; 95% CI, 18.4 to 24.0). After the exclusion of unsupervised ingestion of dietary supplements by children, 65.9% (95% CI, 63.2 to 68.5) of emergency department visits for single-supplement-related adverse events involved herbal or complementary nutritional products; 31.8% (95% CI, 29.2 to 34.3) involved micronutrients. Herbal or complementary nutritional products for weight loss (25.5%; 95% CI, 23.1 to 27.9) and increased energy (10.0%; 95% CI, 8.0 to 11.9) were commonly implicated. Weight-loss or energy products caused 71.8% (95% CI, 67.6 to 76.1) of supplement-related adverse events involving palpitations, chest pain, or tachycardia, and 58.0% (95% CI, 52.2 to 63.7) involved persons 20 to 34 years of age. Among adults 65 years of age or older, choking or pill-induced dysphagia or globus caused 37.6% (95% CI, 29.1 to 46.2) of all emergency department visits for supplement-related adverse events; micronutrients were implicated in 83.1% (95% CI, 73.3 to 92.9) of these visits. CONCLUSIONS: An estimated 23,000 emergency department visits in the United States every year are attributed to adverse events related to dietary supplements. Such visits commonly involve cardiovascular manifestations from weight-loss or energy products among young adults and swallowing problems, often associated with micronutrients, among older adults. (Funded by the Department of Health and Human Services.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmsa1504267

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Herbal Medicines and Perioperative Care
Ang-Lee, M. K. (2001) · JAMA · doi:10.1001/jama.286.2.208 · Cited by 981
National Surveillance of Emergency Department Visits for Outpatient Adverse Drug Events
Budnitz, D. S., Pollock, D. A., Weidenbach, K. N., Mendelsohn, A. B., Schroeder, T. J., & Annest, J. L. (2006) · JAMA · doi:10.1001/jama.296.15.1858 · Cited by 891
Self-citation
Dietary Supplement Use in the United States, 2003–2006
Bailey, R. L., Gahche, J. J., Lentino, C. V., Dwyer, J. T., Engel, J. S., Thomas, P. R., Betz, J. M., Sempos, C. T., & Picciano, M. F. (2010) · Journal of Nutrition · doi:10.3945/jn.110.133025 · Cited by 814
Why US adults use dietary supplements
Bailey, R. L., Gahche, J. J., Miller, P. E., Thomas, P. R., & Dwyer, J. T. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.2299 · Cited by 745
Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007.
Nahin, R. L., Barnes, P. M., Stussman, B. J., & Bloom, B. E. (2009) · PubMed · Cited by 583
Dietary Supplements in a National Survey: Prevalence of Use and Reports of Adverse Events
Timbo, B. B., Ross, M., McCarthy, P. V., & Lin, C. J. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.09.002 · Cited by 318
Self-citation
Too Little, Too Late: Ineffective Regulation of Dietary Supplements in the United States
Starr, R. R. (2015) · American Journal of Public Health · doi:10.2105/ajph.2014.302348 · Cited by 190
Herbal medicines: current trends in anesthesiology practice—a hospital survey
Kaye, A. D., Clarke, R. C. N., Sabar, R., Vig, S., Dhawan, K. P., Hofbauer, R., & Kaye, A. M. (2000) · Journal of Clinical Anesthesia · doi:10.1016/s0952-8180(00)00195-1 · Cited by 189
Underreporting the use of dietary supplements and nonprescription medications among patients undergoing a periodic health examination
Hensrud, D. D., Engle, D. D., & Scheitel, S. M. (1999) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)65120-3 · Cited by 153
Hazards of Hindsight — Monitoring the Safety of Nutritional Supplements
Cohen, P. A. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1315559 · Cited by 149

Flagged first, then by citations

Show all 22 references

Research works printed but not linked: 3

Nahin RL, Natl Health Stat Report, 2009, 1
Harel Z, 2013, JAMA Intern Med, 173, 926
10.4065/74.5.443 · DOI · Paper page

Sorted by citations

IOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0173-z · Cited by 1,057
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540
Adverse Effects of Nutraceuticals and Dietary Supplements
Ronis, M. J. J., Pedersen, K. B., & Watt, J. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052844 · Cited by 393
Regulatory landscape of dietary supplements and herbal medicines from a global perspective
Thakkar, S., Anklam, E., Xu, A., Ulberth, F., Li, J., Li, B., Hugas, M., Sarma, N. D., Crerar, S., Swift, S. N., et al. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104647 · Cited by 285
Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings
Tucker, J., Fischer, T., Upjohn, L., Mazzera, D., & Kumar, M. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.3337 · Cited by 251
An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series
Brown, A. C. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.11.001 · Cited by 184
United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts
Oketch-Rabah, H. A., Roe, A. L., Rider, C. V., Bonkovsky, H. L., Giancaspro, G. I., Navarro, V., Paine, M. F., Betz, J. M., Marles, R. J., Casper, S., et al. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.02.008 · Cited by 168
Prohibited Contaminants in Dietary Supplements
Mathews, N. M. (2017) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738117727736 · Cited by 177
The abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research
Henningfield, J. E., Fant, R. V., & Wang, D. W. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4813-4 · Cited by 151
Probiotic use in at-risk populations
Sanders, M. E., Merenstein, D. J., Ouwehand, A. C., Reid, G., Salminen, S., Cabana, M. D., Paraskevakos, G., & Leyer, G. (2016) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2016.07.001 · Cited by 129
Swifter, higher, stronger: What’s on the menu?
Burke, L. M., & Hawley, J. A. (2018) · Science · doi:10.1126/science.aau2093 · Cited by 135
New Dietary Supplements for Obesity: What We Currently Know
Ríos-Hoyo, A., & Gutiérrez-Salmeán, G. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0214-y · Cited by 126
Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide
Enioutina, E. Y., Salis, E. R., Job, K. M., Gubarev, M. I., Krepkova, L. V., & Sherwin, C. M. T. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1268917 · Cited by 122
Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use
Wierzejska, R. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18178897 · Cited by 145
Ashwagandha‐induced liver injury: A case series from Iceland and the US Drug‐Induced Liver Injury Network
Björnsson, H. K., Björnsson, E. S., Avula, B., Khan, I. A., Jonasson, J. G., Ghabril, M., Hayashi, P. H., & Navarro, V. (2020) · Liver International · doi:10.1111/liv.14393 · Cited by 125
Taking Stock of Dietary Supplements' Harmful Effects on Children, Adolescents, and Young Adults
Or, F., Kim, Y., Simms, J., & Austin, S. B. (2019) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2019.03.005 · Cited by 116
Dietary supplements as source of unintentional doping
Kozhuharov, V. R., Ivanov, K., & Ivanova, S. (2022) · BioMed Research International · doi:10.1155/2022/8387271 · Cited by 108
The Prevalence of Dietary Supplement Use among College Students: A Nationwide Survey in Japan
Kobayashi, E., Sato, Y., Umegaki, K., & Chiba, T. (2017) · Nutrients · doi:10.3390/nu9111250 · Cited by 100
Making Decisions About Supplement Use
Maughan, R. J., Shirreffs, S. M., & Vernec, A. R. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0009 · Cited by 111
Chemical Adulterants in Herbal Medicinal Products: A Review
Calahan, J., Howard, D., Almalki, A. J., Gupta, M. P., & Calderón, Á. I. (2016) · Planta Medica · doi:10.1055/s-0042-103495 · Cited by 97
A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation
Nascimento, D. D. C., Rolnick, N. D., Neto, I. V. D. S., Severin, R. S., & Beal, F. L. R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.808622 · Cited by 108
Unpredictable adverse effects of herbal products
Başaran, N., Paslı, D., & Başaran, A. A. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112762 · Cited by 100
Comparative Effects of Low-Dose Rosuvastatin, Placebo, and Dietary Supplements on Lipids and Inflammatory Biomarkers
Laffin, L. J., Bruemmer, D., García, M. G., Brennan, D. M., McErlean, E. S., Jacoby, D. S., Michos, E. D., Ridker, P. M., Wang, T. Y., Watson, K. E., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.10.013 · Cited by 87
Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA)
Cohen, P. A., Travis, J. C., Keizers, P. H. J., Deuster, P. A., & Venhuis, B. J. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1398328 · Cited by 86
Prevalence, Adverse Events, and Factors Associated with Dietary Supplement and Nutritional Supplement Use by US Navy and Marine Corps Personnel
Knapik, J. J., Trone, D. W., Austin, K. G., Steelman, R. A., Farina, E. K., & Lieberman, H. R. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.02.015 · Cited by 86
Clinical Implications of Herbal Supplements in Conventional Medical Practice: A US Perspective
Hassen, G., Belete, G., Carrera, K. G., Iriowen, R., Araya, H., Alemu, T., Solomon, N., Bam, D. S., Nicola, S. M., Araya, M. E., et al. (2022) · Cureus · doi:10.7759/cureus.26893 · Cited by 97
Herbal and Dietary Supplement–Induced Liver Injury
de Boer, Y. S., & Sherker, A. H. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2016.08.010 · Cited by 84
Prevalence of dietary supplement use by gym members in Portugal and associated factors
Ruano, J., & Teixeira, V. H. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00342-z · Cited by 82
Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system
Mazzanti, G., Moro, P. A., Raschi, E., Da Cas, R., & Menniti‐Ippolito, F. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13171 · Cited by 81
The Role of Dietary Antioxidants, Food Supplements and Functional Foods for Energy Enhancement in Healthcare Professionals
Kalogerakou, T., & Αντωνιάδου, Μ. (2024) · Antioxidants · doi:10.3390/antiox13121508 · Cited by 104
The stimulant higenamine in weight loss and sports supplements
Cohen, P. A., Travis, J. C., Keizers, P. H. J., Boyer, F. E., & Venhuis, B. J. (2018) · Clinical Toxicology · doi:10.1080/15563650.2018.1497171 · Cited by 69
Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: a 10-year systematic review of randomised controlled trials
D’Cunha, N. M., Georgousopoulou, E. N., Dadigamuwage, L., Kellett, J., Panagiotakos, D. B., Thomas, J., McKune, A. J., Mellor, D. D., & Naumovski, N. (2018) · British Journal of Nutrition · doi:10.1017/s0007114517003452 · Cited by 68
Actually, natural is neutral
Scott, S. E., & Rozin, P. N. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0891-0 · Cited by 67
Prevalence of Dietary Supplement Use in US Children and Adolescents, 2003-2014
Qato, D. M., Alexander, G. C., Guadamuz, J. S., & Lindau, S. T. (2018) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2018.1008 · Cited by 63
Medicinal plants and their preparations in the European market: Why has the harmonization failed? The cases of St. John's wort, valerian, ginkgo, ginseng, and green tea
Bilia, A. R., & Costa, M. D. C. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153421 · Cited by 62
Prevalence of adulteration in dietary supplements and recommendations for safe supplement practices in sport
Jagim, A. R., Harty, P. S., Erickson, J. L., Tinsley, G. M., Garner, D., & Galpin, A. J. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1239121 · Cited by 66
Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health
Kloner, R. A., Burnett, A. L. “., Miner, M. M., Blaha, M. J., Ganz, P., Goldstein, I., Kim, N. N., Köhler, T., Lue, T. F., McVary, K. T., et al. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad163 · Cited by 70
Protecting consumers from fraudulent health claims: A taxonomy of psychological drivers, interventions, barriers, and treatments
MacFarlane, D., Hurlstone, M. J., & Ecker, U. K. H. (2020) · Social Science & Medicine · doi:10.1016/j.socscimed.2020.112790 · Cited by 64
Patients’ perceptions and use of natural health products
Barry, A. R. (2018) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.1177/1715163518779409 · Cited by 55
Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine
Cohen, P. A., Travis, J. C., Vanhee, C., Ohana, D., & Venhuis, B. J. (2021) · Clinical Toxicology · doi:10.1080/15563650.2021.1894333 · Cited by 54
Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres-Based PlantLIBRA Study
Lüde, S., Vecchio, S., Sinno‐Tellier, S., Dopter, A., Mustonen, H., Vučinić, S., Jonsson, B., Müller, D., Fruchtengarten, L. V. G., Hrubý, K., et al. (2016) · Phytotherapy Research · doi:10.1002/ptr.5604 · Cited by 53
Energy drinks and population health: consumption pattern and adverse effects among Saudi population
Subaiea, G. M., Altebainawi, A. F., & Alshammari, T. M. (2019) · BMC Public Health · doi:10.1186/s12889-019-7731-z · Cited by 61
Complementary and Alternative Medicine Use Among Allergy Practices: Results of a Nationwide Survey of Allergists
Land, M. H., & Wang, J. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.01.017 · Cited by 49
Herbal Medicines: Personal Use, Knowledge, Attitude, Dispensing Practice, and the Barriers among Community Pharmacists in Gondar, Northwest Ethiopia
Gelayee, D. A., Mekonnen, G. B., Atnafie, S. A., Birarra, M. K., & Asrie, A. B. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/6480142 · Cited by 49
Dietary Supplement Adverse Event Report Data From the FDA Center for Food Safety and Applied Nutrition Adverse Event Reporting System (CAERS), 2004-2013
Timbo, B. B., Chirtel, S. J., Ihrie, J., Oladipo, T., Velez-Suarez, L., Brewer, V., & Mozersky, R. (2018) · Annals of Pharmacotherapy · doi:10.1177/1060028017744316 · Cited by 49
Self-citation
European Cardiac Arrhythmia Society Statement on the cardiovascular events associated with the use or abuse of energy drinks
Lévy, S., Santini, L., Capucci, A., Oto, A., Santomauro, M., Riganti, C., Raviele, A., & Cappato, R. (2019) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-019-00610-2 · Cited by 51
Amino acids regulating skeletal muscle metabolism: mechanisms of action, physical training dosage recommendations and adverse effects
Li, G., Li, Z., & Liu, J. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00820-0 · Cited by 66
Critical Differences Between Dietary Supplement and Prescription Omega-3 Fatty Acids: A Narrative Review
Hilleman, D. E., Wiggins, B. S., & Bottorff, M. B. (2020) · Advances in Therapy · doi:10.1007/s12325-019-01211-1 · Cited by 46
Evaluation and Behavior of Spanish Bodybuilders: Doping and Sports Supplements
Sánchez-Oliver, A. J., Puyana, M. G., & Domínguez, R. (2019) · Biomolecules · doi:10.3390/biom9040122 · Cited by 52
Dietary quercetin supplements: Assessment of online product informations and quantitation of quercetin in the products by high‐performance liquid chromatography
Vida, R. G., Fittler, A., Somogyi‐Végh, A., & Poór, M. (2019) · Phytotherapy Research · doi:10.1002/ptr.6382 · Cited by 47
Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions
Cerbin‐Koczorowska, M., Waszyk-Nowaczyk, M., Bakun, P., Gośliński, T. A., & Koczorowski, T. (2021) · Applied Sciences · doi:10.3390/app11114905 · Cited by 46
An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers
Rao, N., Spiller, H. A., Michaels, N. L., Chounthirath, T., Casavant, M. J., Kamboj, A. K., & Smith, G. A. (2017) · Journal of Medical Toxicology · doi:10.1007/s13181-017-0623-7 · Cited by 46
Do We Need Plant Food Supplements? A Critical Examination of Quality, Safety, Efficacy, and Necessity for a New Regulatory Framework
Tawab, M. A. (2017) · Planta Medica · doi:10.1055/s-0043-123764 · Cited by 47
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Douros, A., Bronder, E., Andersohn, F., Klimpel, A., Kreutz, R. H., Garbe, E., & Bolbrinker, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010114 · Cited by 44
Herbal medicines: challenges in the modern world. Part 4. Canada and United States
Job, K. M., Kiang, T. K. L., Constance, J. E., Sherwin, C. M. T., & Enioutina, E. Y. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2016.1238762 · Cited by 38
A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel
Pomeroy, D. E., Tooley, K. L., Probert, B., Wilson, A., & Kemps, E. (2020) · Nutrients · doi:10.3390/nu12020545 · Cited by 47
Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series
Heidemann, L. A., Navarro, V. J., Ahmad, J., Hayashi, P. H., Stolz, A., Kleiner, D. E., & Fontana, R. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4181-7 · Cited by 43
Media hype: Patient and scientific perspectives on misleading medical news
Robledo, I., & Jankovic, J. J. (2017) · Movement Disorders · doi:10.1002/mds.26993 · Cited by 43
Safety assessment of combination therapies in the treatment of obesity: focus on naltrexone/bupropion extended release and phentermine-topiramate extended release
Halpern, B., & Mancini, M. C. (2016) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1247807 · Cited by 42
The FDA and Adulterated Supplements—Dereliction of Duty
Cohen, P. A. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.3329 · Cited by 42
Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters
Kaci, H., Bodnárová, S., Fliszár-Nyúl, E., Lemli, B., Pelantová, H., Valentová, K., Bakos, É., Özvegy‐Laczka, C., & Poór, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114078 · Cited by 40
Mast cell activation disease and the modern epidemic of chronic inflammatory disease
Afrin, L. B. (2016) · Translational Research · doi:10.1016/j.trsl.2016.01.003 · Cited by 39
iDISK: the integrated DIetary Supplements Knowledge base
Rizvi, R. F., Vasilakes, J., Adam, T. J., Melton, G. B., Bishop, J. R., Bian, J., Tao, C., & Zhang, R. (2019) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocz216 · Cited by 38
Rare cause of acute hepatitis: a common energy drink
Harb, J. N., Taylor, Z. A., Khullar, V., & Sattari, M. (2016) · BMJ Case Reports · doi:10.1136/bcr-2016-216612 · Cited by 40
A Behaviourally Informed Approach to Reducing the Risk of Inadvertent Anti-doping Rule Violations from Supplement Use
Backhouse, S. H. (2023) · Sports Medicine · doi:10.1007/s40279-023-01933-x · Cited by 35
Chronological Review and Rational and Future Prospects of Cannabis-Based Drug Development
Namdar, D., Anis, O., Poulin, P., & Koltai, H. (2020) · Molecules · doi:10.3390/molecules25204821 · Cited by 35
Prevalence of, and factors associated with health supplement use in Dubai, United Arab Emirates: a population-based cross-sectional study
Abdulla, N. M., Aziz, F., Blair, I., Grivna, M., Ádám, B., & Loney, T. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2593-6 · Cited by 33
An educational intervention improved knowledge of dietary supplements in college students
Chiba, T., Kobayashi, E., Okura, T., Sekimoto, M., Mizuno, H., Saito, M., & Umegaki, K. (2020) · BMC Public Health · doi:10.1186/s12889-020-08786-3 · Cited by 34
Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition
Pokushalov, E., Ponomarenko, A., Shrainer, E., Kudlay, D. A., & Miller, R. (2024) · Nutrients · doi:10.3390/nu16234033 · Cited by 39
Behaviors of consumers, physicians and pharmacists in response to adverse events associated with dietary supplement use
Chiba, T., Sato, Y., Kobayashi, E., Ide, K., Yamada, H., & Umegaki, K. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0239-4 · Cited by 33
Adverse Events to Food Supplements Containing Red Yeast Rice: Comparative Analysis of FAERS and CAERS Reporting Systems
Raschi, E., Girardi, A. M., Poluzzi, E., Forcesi, E., Menniti‐Ippolito, F., Mazzanti, G., & Ponti, F. D. (2018) · Drug Safety · doi:10.1007/s40264-018-0661-3 · Cited by 33
Factors Related to Disclosure and Nondisclosure of Dietary Supplements in Primary Care, Integrative Medicine, and Naturopathic Medicine
Guzman Jennifer, R., Paterniti, D. A., Yihang, L., & Tarn, D. M. (2019) · Journal of Family Medicine and Disease Prevention · doi:10.23937/2469-5793/1510109 · Cited by 33
Herbal medications and other dietary supplements. A clinical review for physicians caring for older people
Pitkälä, K. H., Suominen, M. H., Bell, J. S., & Strandberg, T. E. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1197414 · Cited by 32
An evaluation of randomized controlled trials on nutraceuticals containing traditional Chinese medicines for diabetes management: a systematic review
Shi, J., Hu, H., Harnett, J., Zheng, X., Liang, Z., Wang, Y., & Ung, C. O. L. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0276-3 · Cited by 32
False and misleading health-related claims in food supplements on Spanish radio: an analysis from a European Regulatory Framework
Molina, C. M., Oliver, S. P., & García-Arranz, A. (2021) · Public Health Nutrition · doi:10.1017/s1368980021002007 · Cited by 31
Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA
Cohen, P. A., Avula, B., Venhuis, B. J., Travis, J. C., Wang, Y., & Khan, I. A. (2016) · Drug Testing and Analysis · doi:10.1002/dta.1976 · Cited by 35
Evidence for the efficacy and safety of herbal weight loss preparations
Farrington, R., Musgrave, I., & Byard, R. W. (2019) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2019.01.009 · Cited by 34
Effect of respiratory muscle training on dysphagia in stroke patients—A retrospective pilot study
Arnold, R. J., & Bausek, N. (2020) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.483 · Cited by 31
The use of herbal and dietary supplement among community-dwelling elderly in a suburban town of Malaysia
Wahab, M. S. A., Zaini, M. H., Ali, A. A., Sahudin, S., Mehat, M. Z., Hamid, H. A., Mustaffa, M. F., Othman, N., & Maniam, S. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03287-1 · Cited by 31
Dietary Supplements for Weight Management: A Narrative Review of Safety and Metabolic Health Benefits
Mah, E., Chen, O., Liska, D. J., & Blumberg, J. B. (2022) · Nutrients · doi:10.3390/nu14091787 · Cited by 31
Nutraceuticals
Télessy, I. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813148-0.00024-4 · Cited by 31
A Content Analysis of Social Media influencers’ “What I Eat in a day” Vlogs on YouTube
Pfender, E. J., Wanzer, C. V., & Bleakley, A. (2023) · Health Communication · doi:10.1080/10410236.2023.2260966 · Cited by 42
Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats
Song, Y.-K., Yoon, J., Woo, J. K., Kang, J., Lee, K., Oh, S. H., Chung, S., & Maeng, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050397 · Cited by 30
Dietary Supplement Use among Non-athlete Students at a Canadian University: A Pilot-Survey
Khoury, D. T. D. E., Hansen, J., Tabakos, M., Spriet, L. L., & Brauer, P. M. (2020) · Nutrients · doi:10.3390/nu12082284 · Cited by 30
Analysis of Ingredients of Supplements in the National Institutes of Health Supplement Database Marketed as Containing a Novel Alternative to Anabolic Steroids
Cohen, P. A., Sharfstein, J., Kamugisha, A., & Vanhee, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.2818 · Cited by 29
Estimated Exposure to 6 Potentially Hepatotoxic Botanicals in US Adults
Likhitsup, A., Chen, V. L., & Fontana, R. J. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.25822 · Cited by 31
Monitoring of essential and toxic elements in multi-ingredient food supplements produced in European Union
Poniedziałek, B., Niedzielski, P., Kozak, L., Rzymski, P., Wachelka, M., Rzymska, I., Karczewski, J., & Rzymski, P. (2018) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-018-1148-y · Cited by 29
Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems.
Gatti, M., Ippoliti, I., Poluzzi, E., Antonazzo, I., Moro, P., Moretti, U., Menniti-Ippolito, F., Mazzanti, G., de Ponti, F., & Raschi, E. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.07.028 · Cited by 31
Elite athletes, a rationale for the use of dietary supplements: A practical approach
Garthe, I., & Ramsbottom, R. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100234 · Cited by 29
Pharmacotherapy for weight management in the VHA
Semla, T. P., Ruser, C., Good, C. B., Yanovski, S. Z., Ames, D., Copeland, L. A., Billington, C., Ferguson, U. I., Aronne, L. J., Wadden, T. A., et al. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3949-y · Cited by 28
Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols
Conti, F., MCCUE, J., Dituro, P., Galpin, A. J., & Wood, T. R. (2024) · Nutrients · doi:10.3390/nu16152430 · Cited by 33
Is multi-level marketing of nutrition supplements a legal and an ethical practice?
Cárdenas, D., & Fuchs‐Tarlovsky, V. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.03.118 · Cited by 28
E-cigarettes and Weight Loss—Product Design Innovation Insights From Industry Patents
Singh, H., Kennedy, R. D., Lagasse, L. P., Czaplicki, L., & Cohen, J. E. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx112 · Cited by 28
DIETARY SUPPLEMENTS AND THEIR EFFECTS ON HEALTH
Atalay, D., & Erge, H. S. (2018) · Food and Health · doi:10.3153/fh18010 · Cited by 28
Certainty and uncertainty in the biological activities of resveratrol
Drago, L., Ciprandi, G., Brindisi, G., Brunese, F. P., Dinardo, G., Gori, A., Indolfi, C., Naso, M., Tondina, E., Trincianti, C., et al. (2024) · Food Frontiers · doi:10.1002/fft2.375 · Cited by 27
Trends in dietary supplement use among athletes selected for doping controls
Lauritzen, F., & Gjelstad, A. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1143187 · Cited by 27
Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users
Chiba, T., & Tanemura, N. (2022) · Nutrients · doi:10.3390/nu14194114 · Cited by 29
Dietary supplement and complementary and alternative medicine use among older adults in Australia and the United States
Fravel, M. A., Ernst, M. E., Gilmartin‐Thomas, J., Woods, R. L., Orchard, S. G., Owen, A. J., & the ASPirin in Reducing Events in the Elderly Investigator Group (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18305 · Cited by 26
Using natural language processing methods to classify use status of dietary supplements in clinical notes
Fan, Y., & Zhang, R. (2018) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-018-0626-6 · Cited by 26

Authors: Geller, A. I., Shehab, N., Weidle, N. J., Lovegrove, M. C., Wolpert, B. J., Timbo, B. B., Mozersky, R. P., & Budnitz, D. S.
Affiliations: Center for Food Safety and Applied Nutrition (US)
Centers for Disease Control and Prevention (US)
United States Food and Drug Administration (US)
ORCID: Geller, Andrew I.
Shehab, Nadine
Lovegrove, Maribeth C.
Wolpert, Beverly J.
Budnitz, Daniel S.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2015-10-15
Volume: 373
Issue: 16
Pages: 1531-1540
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmsa1504267
PMC: PMC6196363
OpenAlex: W2330664058
Cited by: 502
References: 22
Citations by year: 2026: 35 · 2025: 44 · 2024: 41 · 2023: 46 · 2022: 50 · 2021: 45 · 2020: 58 · 2019: 40 · 2018: 47 · 2017: 48 · 2016: 43 · 2015: 5
FWCI: 93.54
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services
U.S. Consumer Product Safety Commission
National Institutes of Health (CC999999)
Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords: dietary supplements, emergency department visits, micronutrients, weight loss supplements, energy supplements, hospitalization, choking, dysphagia, tachycardia, emergency department surveillance, young adults, older adults, supplement safety
MeSH terms: Adolescent, Adult, Aged, Complementary Therapies, Calcium, Child, Child, Preschool, Emergency Service, Hospital, Female, Hospitalization, Humans, Iron, Phytotherapy, Middle Aged, Population Surveillance, Potassium, United States, Age Distribution, Micronutrients, Dietary Supplements, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Emergency Department Visits for Adverse Events Related to Dietary Supplements

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks