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Protein detection by optical shift of a resonant microcavity
Abstract
We present an optical biosensor with unprecedented sensitivity for detection of unlabeled molecules. Our device uses optical resonances in a dielectric microparticle (whispering gallery modes) as the physical transducing mechanism. The resonances are excited by evanescent coupling to an eroded optical fiber and detected as dips in the light intensity transmitted through the fiber at different wavelengths. Binding of proteins on the microparticle surface is measured from a shift in resonance wavelength. We demonstrate the sensitivity of our device by measuring adsorption of bovine serum albumin and we show its use as a biosensor by detecting streptavidin binding to biotin.
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Citations
Cited by
Vahala, K. J. (2003) · Nature · doi:10.1038/nature01939 · Cited by 4,878
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Armani, D. K., Kippenberg, T. J., Spillane, S. M., & Vahala, K. J. (2003) · Nature · doi:10.1038/nature01371 · Cited by 2,214
Recent progress in nanoimprint technology and its applications
Guo, L. J. (2004) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/37/11/r01 · Cited by 733
Fundamental limits and non-reciprocal approaches in non-Hermitian quantum sensing
Lau, H.-K., & Clerk, A. A. (2018) · Nature Communications · doi:10.1038/s41467-018-06477-7 · Cited by 380
Optical ring resonators for biochemical and chemical sensing
Sun, Y., & Fan, X. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4237-z · Cited by 355
Metadata
- Authors
- Vollmer, F., Braun, D., Libchaber, A., Khoshsima, M., Teraoka, I., & Arnold, S.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2002-05-27
- Volume
- 80
- Issue
- 21
- Pages
- 4057-4059
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2015665105
- Cited by
- 903
- References
- 0
- FWCI
- 24.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vollmer, F., Braun, D., Libchaber, A., Khoshsima, M., Teraoka, I., & Arnold, S. (2002). Protein detection by optical shift of a resonant microcavity. Applied Physics Letters. https://doi.org/10.1063/1.1482797
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