The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ultrasensitive, label-free, and real-time immunodetection using silicon field-effect transistors
Abstract
Ultrasensitive, label-free, and real-time prostate-specific antigen (PSA) sensor was developed using n-type silicon nanowire-based structures configured as field-effect transistors using the conventional “top-down” semiconductor processes. Specific binding of PSA with antibody of PSA (anti-PSA) immobilized on the Si surface through covalent linkage leads to a conductivity change in response to variations of electric field at the surface. The conductance changes depending on PSA concentrations and pH values in solution according to isoelectric point of PSA provide the evidence of the real-time detection of 1fg∕ml PSA. The authors also explored the sensitivity of PSA immunodetection depending on both Si–field-effect transistors (FET) dimensions and doping concentrations to provide strategy for fabrication of an ultrasensitive Si-FET biosensor.
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Citations
Cites
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Cited by
Mani, V., Chikkaveeraiah, B. V., Patel, V., Gutkind, J. S., & Rusling, J. F. (2009) · ACS Nano · doi:10.1021/nn800863w · Cited by 532
Label-free DNA detection with a nanogap embedded complementary metal oxide semiconductor
Kim, C.-H., Jung, C., Lee, K.-B., Park, H. G., & Choi, Y.-K. (2011) · Nanotechnology · doi:10.1088/0957-4484/22/13/135502 · Cited by 103
Shalev, G., Landman, G., Amit, I., Rosenwaks, Y., & Levy, I. (2013) · NPG Asia Materials · doi:10.1038/am.2012.75 · Cited by 61
Kumar, S., Singh, B., & Singh, Y. (2021) · IEEE Sensors Journal · doi:10.1109/jsen.2021.3056385 · Cited by 39
Metadata
- Authors
- Kim, A., Ah, C. S., Yu, H. Y., Yang, J.-H., Baek, I.-B., Ahn, C.-G., Park, C. W., Jun, M. S., & Lee, S.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2007-09-03
- Volume
- 91
- Issue
- 10
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2068235344
- Cited by
- 250
- References
- 1
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, A., Ah, C. S., Yu, H. Y., Yang, J.-H., Baek, I.-B., Ahn, C.-G., Park, C. W., Jun, M. S., & Lee, S. (2007). Ultrasensitive, label-free, and real-time immunodetection using silicon field-effect transistors. Applied Physics Letters. https://doi.org/10.1063/1.2779965
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
