Cockroach allergens and asthma

Arruda, L.Karla; Vailes, Lisa D.; Ferriani, Virginia P.L.; Santos, Ana Beatriz R.; Pomés, Anna; Chapman, Martin D.

doi:10.1067/mai.2001.112854

Cited by 260Indoor Air Quality and Microbial ExposureAsthma and respiratory diseasesAllergic Rhinitis and Sensitization

Cockroach allergens and asthma

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Arruda, L.Karla, Vailes, Lisa D., Ferriani, Virginia P.L., Santos, Ana Beatriz R., Pomés, Anna, Chapman, Martin D.·2001·Journal of Allergy and Clinical Immunology

DOI 10.1067/mai.2001.112854

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Abstract

Asthma and allergy are the most common diseases associated with cockroach infestation of houses in the United States and other parts of the world. Sensitization and exposure to cockroach allergens is associated with increased asthma morbidity in the United States, especially among lower socioeconomic groups, including African American and Hispanic populations. Exposure to cockroach allergens in the first 3 months of life has been associated with repeated wheezing and asthma. The principal domestic cockroach species are Blattella germanica and Periplaneta americana. Both species produce several potent allergens, including Bla g 2 (inactive aspartic proteinase), Bla g 4 (calycin), Bla g 5 (glutathione-S-transferase), the group 1 cross-reactive allergens Bla g 1 and Per a 1, and tropomyosin. Structural homology between tropomyosins from cockroaches, mites, and shrimp may explain clinical cases of the oral allergy syndrome. The 3-dimensional structures of several cockroach allergens are known, and biologically active recombinant allergens have been produced in high-level expression vectors. The use of recombinant cockroach allergens should allow mechanisms of cockroach-induced asthma to be investigated and may lead to the development of new approaches to asthma treatment. Environmental allergen measurements of Bla g 1 and Bla g 2 have allowed exposure levels that cause allergic sensitization to be established. Abatement studies have shown that a sustained decrease in cockroach allergen levels is difficult but can be accomplished by professional application of insecticides, together with rigorous household cleaning. Cockroach asthma is an important public health problem that affects patients who are the least likely to be compliant with treatment with asthma medications or environmental control. Patient education, improvements in the housing stock, and improvements in environmental and immunologic treatment strategies are likely to be the most successful approaches to reduce the prevalence of cockroach-induced asthma.

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Allergens related to cockroach sensitization include Bla g 1, Bla g 2, Bla g 4, and Bla g 5, although tropomyosins Bla g 7 and/or Per a 7 can be important in certain populations.
“Allergens related to sensitization to cockroaches are Bla g 1, Bla g 2, Bla g 4, and Bla g 5, although in certain populations tropomyosins (Bla g 7 and/or Per a 7) can be important.1000”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1000]

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510 Comparative modeling of Bla g 2, a cockroach allergen and inactive aspartic proteinase
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956 Expression of cockroach tropomysin in pichia pastoris and purification of the natural allergen from periplaneta americana extract
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244 Cockroach and dust mite allergen exposure in homes of children with acute episodes of wheezing
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Authors: Arruda, L. K., Vailes, L. D., Ferriani, V. P. L., Santos, A. B. R., Pomés, A., & Chapman, M. D.
Affiliations: Universidade de São Paulo (BR)
ORCID: Arruda, L.Karla
Pomés, Anna
Chapman, Martin D.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2001-03
Volume: 107
Issue: 3
Pages: 419-428
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1067/mai.2001.112854
OpenAlex: W2030477185
Cited by: 260
References: 82
Citations by year: 2026: 8 · 2025: 6 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 15 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 15 · 2013: 16 · 2012: 14
FWCI: 1.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
National Institutes of Health (5r01ai032557-08)
National Institute of Allergy and Infectious Diseases (AI34607, AI 32557)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords: cockroach allergens, Blattella germanica, Periplaneta americana, Bla g 1, Bla g 2, tropomyosin, cross-reactive allergens, oral allergy syndrome, allergen sensitization, allergen exposure, insecticides, household cleaning, socioeconomic disparities, asthma morbidity, recombinant allergens, allergen structure
MeSH terms: Allergens, Animals, Asthma, Cockroaches

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