The DOI matches its Crossref record; 19 of the 22 references it cites were found in a registry or an index.
Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department
Abstract
Study objectives We sought to document the degree of polypharmacy, the frequency of adverse drug-related events (ADREs) leading to emergency department presentation that were recognized by emergency physicians, and the frequency of potential adverse drug interactions (PADIs) in medication regimens of elderly patients in the ED.Methods We conducted a retrospective chart review on 300 randomly selected ED visits made by patients 65 years of age and older between January 1 and December 31, 1998. ADREs were defined according to a standardized algorithm. PADIs were identified by using the drug interaction database PharmVigilance.Results After excluding 17 patient visits with inadequate documentation, 283 were left for review. Of these, 257 (90.8%) patients were taking 1 or more medications (prescribed or over the counter). The number of medications consumed ranged from 0 to 17 and averaged 4.2 (SD+/-3.1) drugs per patient. ADREs accounted for 10.6% of all ED visits in our patient group. The most frequently implicated classes of medications were nonsteroidal anti-inflammatory drugs, antibiotics, anticoagulants, diuretics, hypoglycemics, beta-blockers, calcium-channel blockers, and chemotherapeutic agents. Thirty-one percent of all patients in our group had at least 1 PADI in their medication list. Among patients who presented because of an ADRE, 50% had at least 1 PADI in their medication list that was unrelated to the ADRE with which they presented.Conclusion ADREs are an important cause of ED presentation in the elderly. PADIs are found in a significant proportion of medication lists. Emergency physicians must be vigilant in monitoring elderly patients for medication-related problems.
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“the importance of medication counts in the model may either reflect a proxy feature for medical complexity or indicate that polypharmacy itself is a risk factor [42,43].”
From Predicting hospital admission at emergency department triage using machine learning (2018) · cites this paper as [42]
Citations
Cites
Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
Bates, D. W. (1995) · JAMA · doi:10.1001/jama.1995.03530010043033 · Cited by 2,127
Classen, D. C. (1997) · JAMA · doi:10.1001/jama.277.4.301 · Cited by 1,897
Incidence of adverse drug events and potential adverse drug events
Bates, D. W., Cullen, D. J., & Laird, N. (1995) · International Journal of Trauma Nursing · doi:10.1016/s1075-4210(05)80011-2 · Cited by 537
Karch, F. E. (1975) · JAMA · doi:10.1001/jama.234.12.1236 · Cited by 522
Drug-Related Hospital Admissions
Einarson, T. R. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700702 · Cited by 520
Adverse drug events in hospitalized patients
van den Bemt, P. M. L. A., Egberts, T. C. G., Lenderink, A. W., Verzijl, J. M., Simons, K. A., van der Pol, W. S. C. J. M., & Leufkens, H. G. M. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050611 · Cited by 460
Adverse Drug Events In High Risk Older Outpatients
Hanlon, J. T., Schmader, K. E., Koronkowski, M. J., Weinberger, M., Landsman, P. B., Samsa, G. P., & Lewis, I. K. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02964.x · Cited by 447
"Compendium of pharmaceuticals and specialties".
Krogh, C. (1983) · PubMed · Cited by 410
Drug‐Associated Hospital Admissions in Older Medical Patients
Grymonpre, R., Mitenko, P. A., SITAR, D. S., Aoki, F. Y., & Montgomery, P. R. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb04395.x · Cited by 318
Suspected adverse drug events requiring emergency department visits or hospital admissions
Raschetti, R., Morgutti, M., Menniti‐Ippolito, F., Belisari, A., Rossignoli, A., LONGHINI, P., & GUIDARA, C. L. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050582 · Cited by 183
International drug monitoring. The role of the hospital.
(1969) · PubMed · Cited by 172
Adverse Events After Discontinuing Medications in Elderly Outpatients
Graves, T. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440400055007 · Cited by 145
Drug-related illness in emergency department patients
Dennehy, C. E., Kishi, D. T., & Louie, C. (1996) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/53.12.1422 · Cited by 95
Compendium of Pharmaceuticals and Specialties
Bakst, A. W. (1983) · Therapeutic Drug Monitoring · doi:10.1097/00007691-198309000-00026 · Cited by 92
Potential Adverse Drug Interactions in the Emergency Room
Beers, M. H., Storrie, M., & Lee, G. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-1-61 · Cited by 90
Medication misadventures resulting in emergency department visits at and HMO medical center
Schneitman-McIntire, O., Farnen, T. A., Gordon, N. P., Chan, J., & Toy, W. A. (1996) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/53.12.1416 · Cited by 87
Potential Medication-Related Problems in Noninstitutionalized Elderly
Shimp, L. A., Ascione, F. J., Glazer, H. M., & Atwood, B. F. (1985) · Annals of Pharmacotherapy · doi:10.1177/106002808501901024 · Cited by 63
Medication use in seniors: challenges and solutions.
Tamblyn, R. M. (1996) · PubMed · Cited by 60
Adverse Drug Reaction Surveillance in an Emergency Room
Stoukides, C. A., D'Agostino, P. R., & Kaufman, M. B. (1993) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/50.4.712 · Cited by 40
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Clinical consequences of polypharmacy in elderly
Maher, R. L., Hanlon, J. T., & Hajjar, E. R. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.827660 · Cited by 1,970
Boyd, C. M., & Fortin, M. (2010) · Public health reviews · doi:10.1007/bf03391611 · Cited by 701
Older Patients in the Emergency Department: A Review
Samaras, N., Chevalley, T., Samaras, D., & Gold, G. (2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.04.015 · Cited by 656
de Vries, T. I., Cooney, M. T., Selmer, R. M., Hageman, S. H. J., Pennells, L. A. M., Wood, A., Kaptoge, S. K., Xu, Z., Westerink, J., Rabanal, K. S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab312 · Cited by 682
The challenge of managing drug interactions in elderly people
Mallet, L., Spinewine, A., & Huang, A. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61092-7 · Cited by 536
Metadata
- Authors
- Hohl, C. M., Dankoff, J., Colacone, A., & Afilalo, M.
- Affiliations
- Jewish General Hospital (CA)
- Venue
- Annals of Emergency Medicine
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 38
- Issue
- 6
- Pages
- 666-671
- ISSN
- 0196-0644 (ISSN-L)
- OpenAlex
- W2034981842
- Cited by
- 477
- References
- 22
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 20 · 2023: 14 · 2022: 20 · 2021: 15 · 2020: 16 · 2019: 22 · 2018: 33 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 25 · 2013: 29 · 2012: 24
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
- Keywords
- polypharmacy, adverse drug interactions, elderly patients, emergency department visits, drug-related problems, drug safety, nonsteroidal anti-inflammatory drugs, anticoagulants, antibiotics, over-the-counter drugs
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Drug Interactions, Drug Therapy, Combination, Emergency Service, Hospital, Female, Hospitals, General, Humans, Male, Quebec, Retrospective Studies
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