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Human Papillomavirus Infection and Survival in Oral Squamous Cell Cancer: A Population‐Based Study
Abstract
OBJECTIVE: To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma. STUDY DESIGN: Two hundred fifty‐four patients diagnosed with primary oral cancer were studied for survival in relation to tumor HPV type 16 status. Kaplan‐Meier analysis and Cox proportional hazard models were used to assess survival and estimate hazard ratios adjusted for potential confounders. RESULTS: HPV type 16 DNA was detected in 15.1% of tumors. HPV 16 positive patients had significantly reduced all‐cause mortality (hazard ratio [HR] estimates = 0.34, 95% CI = 0.14, 0.83) and disease‐specific mortality (HR = 0.17, 95% CI = 0.04, 0.76) compared with HPV 16 negative patients after adjustment for age, stage, treatment, smoking, alcohol, education, and comorbid disease. CONCLUSIONS: The presence of HPV type 16 DNA is independently associated with a favorable prognosis in patients with oral squamous cell carcinoma. CLINICAL SIGNIFICANCE: Although HPV genotyping is currently not widely available, it may provide important prognostic information.
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Cited by
Fakhry, C., Westra, W. H., Li, S., Cmelak, A., Ridge, J. A., Pinto, H., Forastiere, A., & Gillison, M. L. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn011 · Cited by 2,779
Gillison, M. L., D'Souza, G., Westra, W., Sugar, E., Xiao, W., Begum, S., & Viscidi, R. (2008) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djn025 · Cited by 1,543
Gillison, M. L. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.09.011 · Cited by 549
Ritchie, J. M., Smith, E. M., Summersgill, K. F., Hoffman, H. T., Wang, D., Klussmann, J. P., Turek, L. P., & Haugen, T. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.10960 · Cited by 406
Molecular biology of squamous cell carcinoma of the head and neck
Perez-Ordoñez, B., Beauchemin, M., & Jordan, R. C. K. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.007641 · Cited by 314
Metadata
- Authors
- Schwartz, S. R., Yueh, B., McDougall, J. K., Daling, J. R., & Schwartz, S. M.
- Venue
- Otolaryngology–Head and Neck Surgery
- Publisher
- Wiley
- Published
- 2001-07
- Volume
- 125
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0161-6439 (ISSN-L)
- 0194-5998
- 1097-6817
- OpenAlex
- W2014201296
- Cited by
- 287
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwartz, S. R., Yueh, B., McDougall, J. K., Daling, J. R., & Schwartz, S. M. (2001). Human Papillomavirus Infection and Survival in Oral Squamous Cell Cancer: A Population‐Based Study. Otolaryngology–Head and Neck Surgery. https://doi.org/10.1067/mhn.2001.116979
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