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Cited by 35Dermatology and Skin DiseasesPain Mechanisms and TreatmentsMast cells and histamine

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Sensitivity of human scalp skin to pruritic stimuli investigated by intradermal microdialysis in vivo

Rukwied, Roman, Zeck, Susanne, Schmelz, Martin, McGlone, Francis·2002·Journal of the American Academy of Dermatology
DOI 10.1067/mjd.2002.120461
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Abstract

Background Although pruritus is common in scalp skin, the forearm has been the main site for investigation in previous experimental studies. Objective Our purpose was to compare the sensitivity to pruritic stimuli in human scalp and forearm skin. Methods Four microdialysis fibers were inserted intradermally into scalp (n = 10) or forearm skin (n = 10) of healthy male subjects and were perfused with histamine (0.01%) or compound 48/80 (C48/80; 0.05%) for 20 minutes. Total protein content in the dialysate was assessed at 10-minute intervals. Intensity of itching and pain sensation were measured psychophysically. Results Histamine- and C48/80-induced protein extravasation was significantly lower in scalp skin. Histamine and C48/80 invariably provoked an itching sensation in the forearm but only in 4 of 10 applications in the scalp. Conclusion Despite the high prevalence of pruritus, scalp skin is less sensitive to histamine-induced experimental itching. A lower innervation density of pruritic nociceptors and/or different central processing of itching might account for this difference.

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  • Dandruff patients are more reactive (higher itch perception or flaking) than controls to topical applications of histamine or oleic acid to the scalp.

    “Consistent with the structural findings, dandruff patients have been found to be more reactive (higher itch perception or flaking) than controls to topical applications of histamine or oleic acid to the scalp [48,69,70].”

    From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [70]

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Research works printed but not linked: 35

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Metadata

Authors
Rukwied, R., Zeck, S., Schmelz, M., & McGlone, F.
Affiliations
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • Bangor University (GB)
ORCID
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2002-08
Volume
47
Issue
2
Pages
245-250
ISSN
0190-9622 (ISSN-L)
DOI
10.1067/mjd.2002.120461
OpenAlex
W2040012703
Cited by
35
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 4
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords
pruritus, scalp skin, histamine, compound 48/80, protein extravasation, nociceptors, skin innervation, intradermal microdialysis
MeSH terms
Adult, p-Methoxy-N-methylphenethylamine, Forearm, Histamine, Humans, Male, Pruritus, Scalp, Skin, Microdialysis

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