Cited by 568Pain Mechanisms and TreatmentsIon Channels and ReceptorsDermatology and Skin Diseases

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

Andrew, D., Craig, A. D.·2001·Nature Neuroscience

Abstract

We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally.

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Crossref · 10.1038/82924

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Authors
Andrew, D., & Craig, A. D.
Affiliations
Barrow Neurological Institute (US)
Corresponding author
Andrew, D.
Venue
Nature Neuroscience
Published
2001-01
Volume
4
Issue
1
Pages
72-77
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1581789522
Cited by
568
References
34
Citations by year
2026: 9 · 2025: 9 · 2024: 4 · 2023: 21 · 2022: 9 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 9 · 2017: 8 · 2016: 22 · 2015: 29 · 2014: 25 · 2013: 32 · 2012: 24
FWCI
18.72
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns025616-09)
  • National Institute of Neurological Disorders and Stroke (NS25616)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
pruritus, histamine, spinothalamic tract, C-fibers, central sensitization, thalamic projections, conduction velocity, iontophoresis
MeSH terms
Animals, Cats, Histamine, Iontophoresis, Lumbosacral Region, Mustard Plant, Nerve Fibers, Neural Conduction, Neural Pathways, Neurons, Afferent, Pain Measurement, Plant Extracts, Plant Oils, Pruritus, Spinothalamic Tracts, Stimulation, Chemical, Thermosensing, Thalamus

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