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Cited by 26High Altitude and HypoxiaCardiac Imaging and DiagnosticsPulmonary Hypertension Research and Treatments

Increased myocardial blood flow during acute exposure to simulated altitudes

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Kaufmann, Philipp A., Schirlo, Christian, Pavlicek, Vojtech, Berthold, Thomas, Burger, Cyrill, von Schulthess, Gustav K., Koller, Erwin A., Buck, Alfred·2001·Journal of Nuclear Cardiology
DOI 10.1067/mnc.2001.112537
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Abstract

Background Although only poor data exist on changes in myocardial blood flow (MBF) under acute hypoxia, patients with known coronary artery disease are advised not to exceed a moderate altitude exposure of about 2000 m above sea level.Methods and results We measured MBF with positron emission tomography using O-15--labeled water in 8 healthy human volunteers (aged 26 +/- 3 years [mean +/- SD]) at baseline (450 m above sea level, Zurich, Switzerland) and during acute hypoxic hypoxemia induced by inhalation of 2 hypoxic gas mixtures corresponding to altitudes of 2000 and 4500 m. MBF remained unchanged at 2000 m (increase of 10%, not significant) but increased significantly at 4500 m (62%, P <.001), exceeding the relative increase in rate pressure product.Conclusions Our results may explain why exposure to an altitude of 2000 m (corresponding to the cabin pressure in most airplanes during flight) is clinically well tolerated, even by patients with reduced coronary flow reserve, such as those with coronary artery disease. However, at an altitude of 4500 m, MBF increases significantly, supporting the recommendation that patients with impaired flow reserve avoid exposure to higher altitudes.

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Research works printed but not linked: 4

  1. Gregg DW. Regulation of the collateral and coronary circulation of the heart. In: McMichael J, editor. Circulation. Oxford (UK): Blackwell Scientific Publications; 1958.
  2. Iida H, Kanno I, Takahashi A, et al. Measurement of absolute myocar- Journal of Nuclear Cardiology March/April 2001
  3. Rushmer RF. The coronary system. In: Rushmer RF, editor. Cardiovascular dynamics. 2nd ed. Philadelphia: Saunders; 1961. p. 218-9.
  4. Heistad DD, Abboud FM. Circulatory adjustments to hypoxia. Circulation 1980;61:463-70.

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Authors
Kaufmann, P. A., Schirlo, C., Pavlicek, V., Berthold, T., Burger, C., von Schulthess, G. K., Koller, E. A., & Buck, A.
Affiliations
University of Zurich (CH)
Corresponding author
Kaufmann, Philipp A.
ORCID
Venue
Journal of Nuclear Cardiology
Publisher
Elsevier BV
Published
2001-03
Volume
8
Issue
2
Pages
158-164
ISSN
1071-3581 (ISSN-L)
DOI
10.1067/mnc.2001.112537
OpenAlex
W2080113720
Cited by
26
References
44
Citations by year
2023: 1 · 2020: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 1
FWCI
1.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nuclear Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (3232-055002.98)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Keywords
myocardial blood flow, acute hypoxia, altitude exposure, 15O-water PET, coronary artery disease, coronary flow reserve, rate-pressure product, cabin altitude, flight safety
MeSH terms
Acute Disease, Adult, Altitude, Hypoxia, Blood Pressure, Coronary Circulation, Electrocardiography, Female, Heart Rate, Humans, Male, Oxygen Radioisotopes, Respiration, Tomography, Emission-Computed

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