Pulmonary transplantation for advanced bronchioloalveolar carcinoma
Open accessAbstract
BACKGROUND No effective therapy is currently available for the diffuse stage of bronchioloalveolar carcinoma. OBJECTIVE We tested the hypothesis that total lung replacement with standard lung transplantation techniques would provide curative therapy. METHODS Nine patients aged 31 to 58 years with bronchioloalveolar carcinoma were entered in the study. Five patients initially had bilateral diffuse tumor. Four patients had recurrence in the contralateral lung after pulmonary resection. RESULTS Between 1993 and 1998, all 9 patients underwent transplantation (2 single-lung and 7 bilateral transplants, 1 reoperative single-lung transplant, and 1 reoperative bilateral transplant). Two patients had mediastinal node metastasis (level 7) at the time of transplantation, and 1 of these had a frankly invasive adenocarcinoma. Of the 8 patients with pure bronchioloalveolar carcinoma, 6 had recurrent pulmonary tumor after transplantation. In 2 of these patients the tumor was localized and could be resected with left lower lobectomy in one case and left pneumonectomy in the other. One is alive 89 months after transplantation; the other died 82 months after transplantation. Four other patients had a diffuse pattern of pulmonary recurrence. Two died of progressive pulmonary failure; 1 of these had retransplantation with recurrence. A third patient died of cerebral edema shortly after bilateral retransplantation. The other patient is alive with recurrence 39 months after transplantation and has bronchiolitis obliterans. Two patients without recurrence are well with unrestricted performance levels 87 and 76 months after transplantation. CONCLUSIONS Transplantation produces a powerful palliative outcome in patients with advanced bronchioloalveolar carcinoma, but the recurrence rate is high. Transplantation for this indication remains controversial.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The risk of disease recurrence after lung transplant for thoracic malignancy is high.
“The risk of disease recurrence is high.(321, 322, 330)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [322]
The Results report recurrence in 6 of 8 patients transplanted for bronchioloalveolar carcinoma, and the Conclusions give a 75% recurrence rate at five years. This supports a high recurrence risk for that cancer, but the study does not establish the risk for thoracic malignancies generally. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOlder data on patients transplanted for advanced multifocal bronchioalveolar cell carcinoma showed post-transplant survival comparable to patients transplanted for other lung diseases.
“Older data on patients undergoing lung transplant for what was previously referred to as advanced multifocal bronchioalveolar cell carcinoma (BAC) showed post-transplant survival comparable to that of patients transplanted for other lung diseases.(321–323)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [322]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Recurrence of bronchioloalveolar carcinoma in transplanted lungs
Garver, R. I., Zorn, G. L., Wu, X., McGiffin, D. C., Young, K. R., & Pinkard, N. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904083401403 · Cited by 102 · see citing works
Self-citationGrover, F. L., & Piantadosi, S. (1989) · Annals of Surgery · doi:10.1097/00000658-198906000-00016 · Cited by 87 · see citing works
Bronchoalveolar Cell Carcinoma of the Lung
Greco, R. J., Steiner, R. M., Goldman, S., Cotler, H. B., Patchefsky, A. S., & Cohn, H. E. (1986) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)63082-2 · Cited by 85 · see citing works
Bronchioloalveolar carcinoma of the lung: Recurrences and survival in patients with stage I disease
Breathnach, O. S., Kwiatkowski, D. J., Finkelstein, D., Godleski, J. J., Sugarbaker, D. J., Johnson, B. E., & Mentzer, S. J. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.110190 · Cited by 84 · see citing works
Alveolar Cell Carcinoma of the Lung: A Retrospective Analysis of 205 Patients
Harpole, D. H., Bigelow, C., Young, W. G., Wolfe, W. G., & Sabiston, D. C. (1988) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)64685-1 · Cited by 40 · see citing works
Hsu, C., Chen, C.-Y., & Hsu, N. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70233-4 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Weill, D., Benden, C., Corris, P. A., Dark, J. H., Davis, R. D., Keshavjee, S., Lederer, D. J., Mulligan, M. J., Patterson, G. A., Singer, L. G., et al. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2014.06.014 · Cited by 1,329 · see citing works
Self-citationLeard, L. E., Holm, A. M., Valapour, M., Glanville, A. R., Attawar, S., Aversa, M., Campos, S. V., Christon, L. M., Cypel, M., Dellgren, G., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.07.005 · Cited by 821 · see citing works
“321,322,330 Modifying the surgical approach as suggested to reduce aerogenous contamination of donor lungs at the time of implantation may mitigate the risk of relapse post-transplant.”
BackgroundSelf-citationLung transplantation: indications and contraindications
Weill, D. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.06.141 · Cited by 121 · see citing works
Self-citationBronchioloalveolar Carcinoma: A Review
Raz, D. J., He, B., Rosell, R., & Jablons, D. M. (2006) · Clinical Lung Cancer · doi:10.3816/clc.2006.n.012 · Cited by 72 · see citing works
Lung Cancer and Lung Transplantation: A Review
Mathew, J., & Kratzke, R. A. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31819afdd9 · Cited by 51 · see citing works
Malignancy after lung transplantation
Shtraichman, O., & Ahya, V. N. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.126 · Cited by 48 · see citing works
Lung cancer: a rare indication for, but frequent complication after lung transplantation
Raemdonck, D. V., Vos, R., Yserbyt, J., Decaluwe, H., Leyn, P. D., & Verleden, G. M. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.11.05 · Cited by 44 · see citing works
Outcomes for lung transplantation for lung cancer in the United Network for Organ Sharing Registry
Ahmad, U., Wang, Z., Bryant, A. S., Kim, A. W., Kukreja, J., Mason, D. P., Bermudez, C. A., Detterbeck, F. C., & Boffa, D. J. (2012) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2012.04.069 · Cited by 43 · see citing works
Rusch, V. W., Tsuchiya, R., Tsuboi, M., Pass, H. I., Grunenwald, D. H., & Goldstraw, P. G. (2006) · Journal of Thoracic Oncology · doi:10.1016/s1556-0864(15)30006-x · Cited by 38 · see citing works
Lung transplantation for non-small cell lung cancer and multifocal bronchioalveolar cell carcinoma
Glanville, A. R., & Wilson, B. E. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30297-3 · Cited by 30 · see citing works
Review: Update on lung transplantation
Gottlieb, J. (2008) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465808093514 · Cited by 28 · see citing works
Bronchioloalveolar carcinoma: myths and realities in the surgical management
Barlési, F. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00190-8 · Cited by 26 · see citing works
Gómez‐Román, J., Valle, C. E. D., Zarrabeitia, M. T., Martínez, J. M. C., Goñi, F. Z., Mons, R., Cuevas, J., & Val‐Bernal, J. F. (2005) · Pathology International · doi:10.1111/j.1440-1827.2005.01872.x · Cited by 24 · see citing works
Transplantation for lung cancer
Machuca, T., & Keshavjee, S. H. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328357fff6 · Cited by 18 · see citing works
Actualización del trasplante pulmonar en España
Borro, J. M. (2005) · Archivos de Bronconeumología · doi:10.1157/13077957 · Cited by 17 · see citing works
Imaging of recurrent lung cancer
Bogot, N. (2004) · Cancer Imaging · doi:10.1102/1470-7330.2004.0002 · Cited by 15 · see citing works
Lung transplantation for lung cancer: A systematic review of the literature
Elsolh, B., Bayat, Z., Lyu, D. M., Lin, J., & Wakeam, E. (2023) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2023.05.011 · Cited by 12 · see citing works
Current and future role of double-lung transplantation for bilateral lung cancer
Lee, J., Schellenberg, S., Chung, L. I., Bharat, A., & Chae, Y. K. (2023) · Transplantation Reviews · doi:10.1016/j.trre.2023.100772 · Cited by 11 · see citing works
Emerging approaches to advanced bronchioloalveolar carcinoma
West, H. (2006) · Current Treatment Options in Oncology · doi:10.1007/s11864-006-0033-6 · Cited by 12 · see citing works
Recurrence of primary disease following lung transplantation
Esendagli, D. R., Ntiamoah, P., Küpeli̇, E., Bhardwaj, A., Ghosh, S., Mukhopadhyay, S., & Mehta, A. C. (2022) · ERJ Open Research · doi:10.1183/23120541.00038-2022 · Cited by 14 · see citing works
Lung Transplantation for Multifocal Lung Adenocarcinoma (Multifocal Lung Carcinoma)
Kachala, S. S., & Murthy, S. C. (2014) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2014.07.011 · Cited by 9 · see citing works
Lee, J., Chuchuca, M. J. A., Yu, J., Chung, L. I., Bharat, A., & Chae, Y. K. (2023) · Annals of Transplantation · doi:10.12659/aot.941301 · Cited by 8 · see citing works
West, H. (2014) · PubMed · Cited by 7 · see citing works
Egan, T. M., & Detterbeck, F. C. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2003.146 · Cited by 7 · see citing works
Poor results after surgery for bronchioloalveolar carcinoma
Damhuis, R. A. M., Schütte, P. R., Varin, O., van den Berg, P. M., Heinhuis, R., & Plaisier, P. W. (2006) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2006.02.007 · Cited by 6 · see citing works
Mesothelioma after lung transplantation
Chhajed, P. N. (2006) · Thorax · doi:10.1136/thx.2004.032573 · Cited by 6 · see citing works
Lung cancer in lung transplant—management and outcomes
Rappaport, J. M. P., & Ahmad, U. (2021) · Current Challenges in Thoracic Surgery · doi:10.21037/ccts-20-142 · Cited by 4 · see citing works
Chae, Y. K., Oh, Y., Kim, L., Park, J. H., Djunadi, T. A., Shah, Z., Chung, L. I., Yoon, S. M., Duan, R., Lee, J., et al. (2024) · The Oncologist · doi:10.1093/oncolo/oyae263 · Cited by 3 · see citing works
Zhang-Velten, E. R., Gerber, D. E., & Westover, K. D. (2020) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2020.100094 · Cited by 3 · see citing works
Bronchioloalveolar Carcinoma and Ground Glass Opacities
Altorki, N. K. (2005) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.03.080 · Cited by 3 · see citing works
Zander, D. S. (2008) · Springer eBooks · doi:10.1007/978-0-387-68792-6_23 · Cited by 3 · see citing works
Lung transplantation proposed as a cure for cancer
Pullen, L. C. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.06.012 · Cited by 2 · see citing works
[Lung transplantation for lung carcinoma: a case report and literature review].
Wang, Y., & Chen, J. (2011) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2011.07.14 · Cited by 2 · see citing works
Editorial Commentary: A New Set of Lungs or a New Pair of Glasses?
Raemdonck, D. E. V. (2015) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2015.02.009 · Cited by 2 · see citing works
Malignancy Following Lung Transplantation
Benvenuto, L. J., Aversa, M. M., & Arcasoy, S. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00120-7 · Cited by 2 · see citing works
Shamji, F. M., & Deslauriers, J. (2013) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2013.05.005 · Cited by 1 · see citing works
Carcinome bronchioloalvéolaire et transplantation pulmonaire
Avrillon, V., Philit, F., Chalabreysse, L., Chumbi-Flores, R.-W., Tronc, F., Thivolet-Béjui, F., & Mornex, J. (2011) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2011.11.004 · Cited by 1 · see citing works
Zwintscher, N. P., de Perrot, M. E., Cypel, M., & Keshavjee, S. H. (2025) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2025.08.004 · Cited by 1 · see citing works
Rizzo, S., Petrella, F., Passaro, A., de Marinis, F., & Bellomi, M. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.07.23 · Cited by 1 · see citing works
Heart and lung transplantation
McGiffin, D. C., & Marasco, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810491-0.00002-3 · Cited by 1 · see citing works
Self-citationBurke, M. M., & Rice, A. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3369-8.00011-2 · Cited by 1 · see citing works
Berry, G. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-29683-8_5 · Cited by 1 · see citing works
Jaksch, P., Mehrain, S., Kienzl, D., & Bankier, A. A. (2007) · Medical radiology · doi:10.1007/978-3-540-68218-9_5 · Cited by 1 · see citing works
Bronchioloalveolar Carcinoma of the Lung
Riely, G. J., & Miller, V. A. (2012) · doi:10.1002/9781118464557.ch25 · Cited by 1 · see citing works
Patient Selection and Indications for Lung Transplantation
Becker, J. B., & Garrity, E. R. (2014) · Wiley eBooks · doi:10.1002/9781118873434.ch31 · Cited by 1 · see citing works
Créquit, P., Cadranel, J. L., Mal, H., Grigoriu, B. D., & Berghmans, T. (2019) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2019.07.003 · Cited by 1 · see citing works
Recurrent Disease after Lung Transplantation
Astor, T. L. (2014) · doi:10.1002/9781118873434.ch80
Management of Multifocal Bronchioloalveolar Carcinoma (BAC)
West, H. (2014) · Lung Cancer · doi:10.1002/9781118468791.ch9
What’s New in General Thoracic Surgery
Naunheim, K. S. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00380-6
Lung Transplantation in Spain: an Update
Borro, J. M. (2005) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(06)60261-9
Surgery for Bronchoalveolar Lung Cancer
Deb, S. J., & Deschamps, C. C. (2007) · Springer eBooks · doi:10.1007/978-1-84628-474-8_20
LUNG AND HEART-LUNG TRANSPLANTATION
Moffatt, S. D., & Reitz, B. A. (2006)
Batiste, R. C., & Litzky, L. A. (2012) · Pathology Case Reviews · doi:10.1097/pcr.0b013e31826d8894
Emerging Approaches to Advanced ar Carcinoma
West, H. (2006)
Puri, V., Fernández, F. G., & Patterson, G. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5225-8.00014-3
(2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00838-9
Lung Cancer and Lung Transplantation
Jablonski, R. P. (2023) · Current Pulmonology Reports · doi:10.1007/s13665-023-00301-4
Heart and lung transplantation
Doi, A., Marasco, S., Patel, H. C., Paraskeva, M. A., & McGiffin, D. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22148-4.00002-2
Self-citation
- Authors
- Zorn, G. L., McGiffin, D. C., Young, K. R., Alexander, C. B., Weill, D., & Kirklin, J. K.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 125
- Issue
- 1
- Pages
- 45-48
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2002315000
- Semantic Scholar
- 34cb5f5ee0ef5fe844f07e608af63293aa2d897f
- Cited by
- 58
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 1 · 2012: 4
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Metastasis and carcinoma case studies
- Keywords
- lung transplantation, bronchioloalveolar carcinoma, adenocarcinoma, tumor recurrence, bilateral lung transplantation, retransplantation, mediastinal lymph node metastasis, palliative care, bronchiolitis obliterans, survival outcomes
- MeSH terms
- Adult, Adenocarcinoma, Bronchiolo-Alveolar, Female, Humans, Lung Neoplasms, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Recurrence, Local, Palliative Care, Survival Rate, Lung Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
