Adverse pregnancy outcomes in snuff users
Abstract
Objective The purpose of the study was to evaluate the effects of smokeless tobacco use during pregnancy.Study design We examined birth weight, preterm delivery, and preeclampsia in women who were delivered of singleton, live-born infants in Sweden from 1999 through 2000. For each snuff user, 10 cigarette smokers and 10 tobacco nonusers were selected randomly.Results After exclusions, 789 snuff users, 11,240 smokers, and 11,495 nonusers remained. Compared with nonusers, adjusted mean birth weight was reduced in snuff users by 39 g (95% CI, 6-72 g) and in smokers by 190 g (95% CI, 178-202 g). Preterm delivery was increased in snuff users and smokers (adjusted odds ratios, 1.98 [95% CI, 1.46-2.68] and 1.57 [95% CI, 1.38-1.80], respectively). Preeclampsia was reduced in smokers (adjusted odds ratio, 0.63; 95% CI, 0.53-0.75) but increased in snuff users (adjusted odds ratio, 1.58; 95% CI, 1.09-2.27).Conclusion Snuff use was associated with increased risk of preterm delivery and preeclampsia. Snuff does not appear to be a safe alternative to cigarettes during pregnancy.
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Smokeless tobacco use during pregnancy has no clear association with fetal growth restriction.
“but no clear association with fetal growth restriction.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [37]
A Swedish study showed that snus is associated with birthweight reduction.
“A Swedish study showed that snus is associated to birthweight reduction [19].”
From The effect of swedish snuff (snus) on offspring birthweight: a sibling analysis (2013) · cites this paper as [19]
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References 18 · Cited by 174
- Authors
- England, L. J., Levine, R. J., Mills, J. L., Klebanoff, M. A., Yu, K. F., & Cnattingius, S.
- Affiliations
- National Institutes of Health (US)
- Karolinska Institutet (SE)
- Corresponding author
- England, Lucinda J
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 189
- Issue
- 4
- Pages
- 939-943
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2035609639
- Cited by
- 174
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 10 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 15 · 2013: 8 · 2012: 13
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- snuff, smokeless tobacco, pregnancy, birth weight, preterm birth, preeclampsia, cigarette smoking, tobacco use, adverse pregnancy outcomes
- MeSH terms
- Birth Weight, Female, Humans, Obstetric Labor, Premature, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Risk Factors, Smoking, Tobacco, Smokeless
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