The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
Open accessAbstract
Hemoglobin degradation is a metabolic process that is central to the growth and maturation of the malaria parasite Plasmodium falciparum. Two aspartic proteases that initiate degradation, plasmepsins (PMs) I and II, have been identified and extensively characterized. Eight additional PM genes are present in the P. falciparum genome. To better understand the enzymology of hemoglobin degradation, it is necessary to determine which of these genes are expressed when hemoglobin degradation is occurring, which encode active enzymes, and which gene products are found in the food vacuole where catabolism takes place. Our genome-wide analysis reveals that PM I, II, and IV and histo-aspartic protease encode hemoglobin-degrading food vacuole proteases. Despite having a histidine in place of one of the catalytic aspartic acids conserved in other aspartic proteases, histo-aspartic protease is an active hydrolase.
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Cites
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., & Leech, J. H. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113766 · Cited by 331
Cited by
A proteomic view of the Plasmodium falciparum life cycle
Florens, L., Washburn, M. P., Raine, J. D., Anthony, R. M., Grainger, M., Haynes, J. D., Moch, J. K., Muster, N., Sacci, J. B., Tabb, D. L., et al. (2002) · Nature · doi:10.1038/nature01107 · Cited by 1,308
Wiesner, J., Ortmann, R., Jomaa, H., & Schlitzer, M. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200569 · Cited by 428
Sijwali, P. S., & Rosenthal, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307720101 · Cited by 276
A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms
Williamson, A. L., Lecchi, P., Turk, B. E., Choe, Y., Hotez, P. J., McKerrow, J. H., Cantley, L. C., Sajid, M., Craik, C. S., & Loukas, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405842200 · Cited by 181
Metadata
- Authors
- Banerjee, R., Liu, J., Beatty, W., Pelosof, L., Klemba, M., & Goldberg, D. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-08
- Volume
- 99
- Issue
- 2
- Pages
- 990-995
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2165174924
- Cited by
- 452
- References
- 1
- FWCI
- 28.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Banerjee, R., Liu, J., Beatty, W., Pelosof, L., Klemba, M., & Goldberg, D. E. (2002). Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.022630099
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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