The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pitx3 is required for development of substantia nigra dopaminergic neurons
Open accessAbstract
Dopaminergic (DA) neurons of substantia nigra in the midbrain control voluntary movement, and their degeneration is the cause of Parkinson's disease. The complete set of genes required to specifically determine the development of midbrain DA subgroups is not known yet. We report here that mice lacking the bicoid -related homeoprotein Pitx3 fail to develop DA neurons of the substantia nigra. Other mesencephalic DA neurons of the ventral tegmental area and retrorubral field are unaltered in their dopamine expression and histological organization. These data suggest that Pitx3-dependent gene expression is specifically required for the differentiation of DA progenitors within the mesencephalic DA system.
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Kawasaki, H., Suemori, H., Mizuseki, K., Watanabe, K., Urano, F., Ichinose, H., Haruta, M., Takahashi, M., Yoshikawa, K., Nishikawa, S.-I., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032662199 · Cited by 477
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An atlas of the protein-coding genes in the human, pig, and mouse brain
Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., et al. (2020) · Science · doi:10.1126/science.aay5947 · Cited by 1,151
Molecular diversity of midbrain development in mouse, human, and stem cells
La Manno, G., Gyllborg, D., Codeluppi, S., Nishimura, K., Salto, C., Zeisel, A., Borm, L. E., Stott, S. R. W., Toledo, E. M., Villaescusa, J. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.027 · Cited by 835
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., & Ericson, J. (2006) · Cell · doi:10.1016/j.cell.2005.10.037 · Cited by 587
The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
Jankovic, J., Chen, S., & Le, W. D. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.09.001 · Cited by 325
Metadata
- Authors
- Nunes, I., Tovmasian, L. T., Silva, R. M., Burke, R. E., & Goff, S. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-03-24
- Volume
- 100
- Issue
- 7
- Pages
- 4245-4250
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068602040
- Cited by
- 385
- References
- 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Nunes, I., Tovmasian, L. T., Silva, R. M., Burke, R. E., & Goff, S. P. (2003). Pitx3 is required for development of substantia nigra dopaminergic neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0230529100
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