The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
Open accessAbstract
Phosphoinositides are critical regulators of ion channel and transporter activity. Defects in interactions of i nwardly r ectifying potassium (Kir) channels with phosphoinositides lead to disease. ATP-sensitive K + channels (K ATP ) are unique among Kir channels in that they serve as metabolic sensors, inhibited by ATP while stimulated by long-chain (LC) acyl-CoA. Here we show that K ATP are the least specific Kir channels in their activation by phosphoinositides and we demonstrate that LC acyl-CoA activation of these channels depends on their low phosphoinositide specificity. We provide a systematic characterization of phosphoinositide specificity of the entire Kir channel family expressed in Xenopus oocytes and identify molecular determinants of such specificity. We show that mutations in the Kir2.1 channel decreasing phosphoinositide specificity allow activation by LC acyl-CoA. Our data demonstrate that differences in phosphoinositide specificity determine the modulation of Kir channel activity by distinct regulatory lipids.
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Citations
Cites
Membrane Phospholipid Control of Nucleotide Sensitivity of K ATP Channels
Shyng, S.-L., & Nichols, C. G. (1998) · Science · doi:10.1126/science.282.5391.1138 · Cited by 559
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Suh, B.-C., & Hille, B. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125859 · Cited by 646
Zhang, H., Craciun, L. C., Mirshahi, T., Rohács, T., Lopes, C. M. B., Jin, T., & Logothetis, D. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00125-9 · Cited by 523
Self-citationThe role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
OUDIT, G. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.015 · Cited by 469
Metadata
- Authors
- Rohács, T., Lopes, C. M. B., Jin, T., Ramdya, P. P., Molnár, Z., & Logothetis, D. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-01-13
- Volume
- 100
- Issue
- 2
- Pages
- 745-750
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2148389925
- Cited by
- 199
- References
- 1
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Rohács, T., Lopes, C. M. B., Jin, T., Ramdya, P. P., Molnár, Z., & Logothetis, D. E. (2003). Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0236364100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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