PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Open accessAbstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.
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Many ion channels and transporters in the plasma membrane depend on PI(4,5)P2 for correct functioning.
“Like endocytosis, many ion channels and transporters in the plasma membrane also depend on the presence of PI(4,5)P2 for correct functioning [112–114].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [112]
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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176 · see citing works
- Authors
- Suh, B.-C., & Hille, B.
- Affiliations
- University of Washington (US)
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2008-06-01
- Volume
- 37
- Issue
- 1
- Pages
- 175-195
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- PMC
- PMC2692585
- OpenAlex
- W2113755495
- Cited by
- 646
- References
- 0
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 26 · 2023: 34 · 2022: 41 · 2021: 42 · 2020: 38 · 2019: 29 · 2018: 34 · 2017: 35 · 2016: 35 · 2015: 44 · 2014: 49 · 2013: 42 · 2012: 52
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Biophysics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 083913, R01GM083913)
- National Institute of Neurological Disorders and Stroke (R37NS008174, NS 08174, R01NS008174)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- phosphatidylinositol 4,5-bisphosphate, ion channels, ion transporters, phosphoinositides, plasma membrane, channel regulation, signaling pathways, lipid signaling, membrane lipids
- MeSH terms
- Binding Sites, Ion Channels, Models, Biological, Models, Chemical, Models, Molecular, Protein Binding, Protein Conformation, Ion Channel Gating, Phosphatidylinositol 4,5-Diphosphate
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