The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The yeast cell-cycle network is robustly designed
Open accessAbstract
The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties and stabilities of such networks, we studied the cell-cycle regulatory network of the budding yeast. With the use of a simple dynamical model, it was demonstrated that the cell-cycle network is extremely stable and robust for its function. The biological stationary state, the G 1 state, is a global attractor of the dynamics. The biological pathway, the cell-cycle sequence of protein states, is a globally attracting trajectory of the dynamics. These properties are largely preserved with respect to small perturbations to the network. These results suggest that cellular regulatory networks are robustly designed for their functions.
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Cited by
Modelling and analysis of gene regulatory networks
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Metadata
- Authors
- Li, F., Long, T., Lu, Y., Ouyang, Q., & Tang, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-03-22
- Volume
- 101
- Issue
- 14
- Pages
- 4781-4786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053961182
- Cited by
- 1,108
- References
- 30
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, F., Long, T., Lu, Y., Ouyang, Q., & Tang, C. (2004). The yeast cell-cycle network is robustly designed. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0305937101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
