The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
Open accessAbstract
Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only β cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-β cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of β cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1 -/- pancreata, which lack the majority of second-phase β cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
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Cites
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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
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Cited by
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Fu, Z., R. Gilbert, E., & Liu, D. (2013) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 732
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus
Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6755 · Cited by 654
Oxidative stress and diabetes: antioxidative strategies
Zhang, P., Li, T., Wu, X., Nice, E. C., Huang, C., & Zhang, Y. (2020) · Frontiers of Medicine · doi:10.1007/s11684-019-0729-1 · Cited by 513
Metadata
- Authors
- Matsuoka, T.-A., Artner, I., Henderson, E., Means, A., Sander, M., & Stein, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-18
- Volume
- 101
- Issue
- 9
- Pages
- 2930-2933
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2067349147
- Cited by
- 273
- References
- 29
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Matsuoka, T.-A., Artner, I., Henderson, E., Means, A., Sander, M., & Stein, R. (2004). The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0306233101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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