The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensing
Open accessAbstract
Diverse biochemical rhythms are generated by thousands of cellular oscillators that somehow manage to operate synchronously. In fields ranging from circadian biology to endocrinology, it remains an exciting challenge to understand how collective rhythms emerge in multicellular structures. Using mathematical and computational modeling, we study the effect of coupling through intercell signaling in a population of Escherichia coli cells expressing a synthetic biological clock. Our results predict that a diverse and noisy community of such genetic oscillators interacting through a quorum-sensing mechanism should self-synchronize in a robust way, leading to a substantially improved global rhythmicity in the system. As such, the particular system of coupled genetic oscillators considered here might be a good candidate to provide the first quantitative example of a synchronization transition in a population of biological oscillators.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441
Self-citation
Cited by
Synchronization in complex networks
Arenas, A., Díaz-Guilera, A., Kurths, J., Moreno, Y., & Zhou, C. (2008) · Physics Reports · doi:10.1016/j.physrep.2008.09.002 · Cited by 3,713
Synthetic biology: new engineering rules for an emerging discipline
Andrianantoandro, E., Basu, S., Karig, D. K., & Weiss, R. (2006) · Molecular Systems Biology · doi:10.1038/msb4100073 · Cited by 1,081
Bistability, Epigenetics, and Bet-Hedging in Bacteria
Veening, J.-W., Smits, W. K., & Kuipers, O. P. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.163002 · Cited by 1,018
A synchronized quorum of genetic clocks
Danino, T., Mondragón-Palomino, O., Tsimring, L., & Hasty, J. (2010) · Nature · doi:10.1038/nature08753 · Cited by 992
Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network
Liu, A. C., Welsh, D. K., Ko, C. H., Tran, H. G., Zhang, E. E., Priest, A. A., Buhr, E. D., Singer, O., Meeker, K., Verma, I. M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.02.047 · Cited by 699
Metadata
- Authors
- Garcia-Ojalvo, J., Elowitz, M. B., & Strogatz, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-07-15
- Volume
- 101
- Issue
- 30
- Pages
- 10955-10960
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2030083295
- Cited by
- 591
- References
- 1
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensing. https://app.cochat.ai/papers/10.1073/pnas.0307095101
- The paper
- Garcia-Ojalvo, J., Elowitz, M. B., & Strogatz, S. H. (2004). Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307095101
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
