The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Bistability, Epigenetics, and Bet-Hedging in Bacteria
Open accessAbstract
Clonal populations of microbial cells often show a high degree of phenotypic variability under homogeneous conditions. Stochastic fluctuations in the cellular components that determine cellular states can cause two distinct subpopulations, a property called bistability. Phenotypic heterogeneity can be readily obtained by interlinking multiple gene regulatory pathways, effectively resulting in a genetic logic-AND gate. Although switching between states can occur within the cells' lifetime, cells can also pass their cellular state over to the next generation by a mechanism known as epigenetic inheritance and thus perpetuate the phenotypic state. Importantly, heterogeneous populations can demonstrate increased fitness compared with homogeneous populations. This suggests that microbial cells employ bet-hedging strategies to maximize survival. Here, we discuss the possible roles of interlinked bistable networks, epigenetic inheritance, and bet-hedging in bacteria.
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Cites
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Cited by
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
Shalek, A. K., Satija, R., Shuga, J., Trombetta, J. J., Gennert, D., Lu, D., Chen, P., Gertner, R. S., Gaublomme, J. T., Yosef, N., et al. (2014) · Nature · doi:10.1038/nature13437 · Cited by 1,000
Maisonneuve, E., Castro-Camargo, M., & Gerdes, K. (2013) · Cell · doi:10.1016/j.cell.2013.07.048 · Cited by 438
RetractedRyall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160
Kerwin, R. E., Jimenez-Gomez, J. M., Fulop, D., Harmer, S. L., Maloof, J. N., & Kliebenstein, D. J. (2011) · The Plant Cell · doi:10.1105/tpc.110.082065 · Cited by 140
Phenotypic Resistance and the Dynamics of Bacterial Escape from Phage Control
Bull, J. J., Vegge, C. S., Schmerer, M., Chaudhry, W. N., & Levin, B. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094690 · Cited by 123
Metadata
- Authors
- Veening, J.-W., Smits, W. K., & Kuipers, O. P.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2008-10-01
- Volume
- 62
- Issue
- 1
- Pages
- 193-210
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2124980889
- Cited by
- 1,018
- References
- 103
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Veening, J.-W., Smits, W. K., & Kuipers, O. P. (2008). Bistability, Epigenetics, and Bet-Hedging in Bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.62.081307.163002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
