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Genomic identification of direct target genes of LEAFY
Open accessAbstract
The switch from vegetative to reproductive development in plants necessitates a switch in the developmental program of the descendents of the stem cells in the shoot apical meristem. Genetic and molecular investigations have demonstrated that the plant-specific transcription factor and meristem identity regulator LEAFY (LFY) controls this developmental transition by inducing expression of a second transcription factor, APETALA1, and by regulating the expression of additional, as yet unknown, genes. Here we show that the additional LFY targets include the APETALA1-related factor, CAULI-FLOWER, as well as three transcription factors and two putative signal transduction pathway components. These genes are up-regulated by LFY even when protein synthesis is inhibited and, hence, appear to be direct targets of LFY. Supporting this conclusion, cis-regulatory regions upstream of these genes are bound by LFY in vivo . The newly identified LFY targets likely initiate the transcriptional changes that are required for the switch from vegetative to reproductive development in Arabidopsis .
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Cites
The evolution of signalling pathways in animal development
Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466
Talbert, P. B., Adler, H. T., Parks, D. W., & Comai, L. (1995) · Development · doi:10.1242/dev.121.9.2723 · Cited by 365
Cited by
Molecular mechanisms of flower development: an armchair guide
Krizek, B. A., & Fletcher, J. C. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1675 · Cited by 624
Whole-Genome Analysis of the SHORT-ROOT Developmental Pathway in Arabidopsis
Levesque, M. P., Vernoux, T., Busch, W., Cui, H., Wang, J. Y., Blilou, I., Hassan, H., Nakajima, K., Matsumoto, N., Lohmann, J. U., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040143 · Cited by 349
Alvarez-Buylla, E. R., Benítez, M., Corvera-Poiré, A., Chaos Cador, Á., de Folter, S., Gamboa de Buen, A., Garay-Arroyo, A., García-Ponce, B., Jaimes-Miranda, F., Pérez-Ruiz, R. V., et al. (2010) · The Arabidopsis Book · doi:10.1199/tab.0127 · Cited by 298
Metadata
- Authors
- William, D. A., Su, Y., Smith, M. R., Lu, M., Baldwin, D. A., & Wagner, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-01-21
- Volume
- 101
- Issue
- 6
- Pages
- 1775-1780
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989334420
- Cited by
- 219
- References
- 2
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- green
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- William, D. A., Su, Y., Smith, M. R., Lu, M., Baldwin, D. A., & Wagner, D. (2004). Genomic identification of direct target genes of LEAFY. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307842100
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