The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Whole-Genome Analysis of the SHORT-ROOT Developmental Pathway in Arabidopsis
Open accessAbstract
Stem cell function during organogenesis is a key issue in developmental biology. The transcription factor SHORT-ROOT (SHR) is a critical component in a developmental pathway regulating both the specification of the root stem cell niche and the differentiation potential of a subset of stem cells in the Arabidopsis root. To obtain a comprehensive view of the SHR pathway, we used a statistical method called meta-analysis to combine the results of several microarray experiments measuring the changes in global expression profiles after modulating SHR activity. Meta-analysis was first used to identify the direct targets of SHR by combining results from an inducible form of SHR driven by its endogenous promoter, ectopic expression, followed by cell sorting and comparisons of mutant to wild-type roots. Eight putative direct targets of SHR were identified, all with expression patterns encompassing subsets of the native SHR expression domain. Further evidence for direct regulation by SHR came from binding of SHR in vivo to the promoter regions of four of the eight putative targets. A new role for SHR in the vascular cylinder was predicted from the expression pattern of several direct targets and confirmed with independent markers. The meta-analysis approach was then used to perform a global survey of the SHR indirect targets. Our analysis suggests that the SHR pathway regulates root development not only through a large transcription regulatory network but also through hormonal pathways and signaling pathways using receptor-like kinases. Taken together, our results not only identify the first nodes in the SHR pathway and a new function for SHR in the development of the vascular tissue but also reveal the global architecture of this developmental pathway.
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Self-citationWang, D., Amornsiripanitch, N., & Dong, X. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020123 · Cited by 774
A novel sensor to map auxin response and distribution at high spatio-temporal resolution
Brunoud, G., Wells, D. M., Oliva, M., Larrieu, A., Mirabet, V., Burrow, A. H., Beeckman, T., Kepinski, S., Traas, J., Bennett, M. J., et al. (2012) · Nature · doi:10.1038/nature10791 · Cited by 741
Self-citationGlobal Analysis of DELLA Direct Targets in Early Gibberellin Signaling in Arabidopsis
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Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth
Sozzani, R., Cui, H., Moreno-Risueno, M. A., Busch, W., Van Norman, J. M., Vernoux, T., Brady, S. M., Dewitte, W., Murray, J. A. H., & Benfey, P. N. (2010) · Nature · doi:10.1038/nature09143 · Cited by 438
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Metadata
- Authors
- Levesque, M. P., Vernoux, T., Busch, W., Cui, H., Wang, J. Y., Blilou, I., Hassan, H., Nakajima, K., Matsumoto, N., Lohmann, J. U., Scheres, B., & Benfey, P. N.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-05-02
- Volume
- 4
- Issue
- 5
- Pages
- e143
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W1574613407
- Cited by
- 349
- References
- 65
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Levesque, M. P., Vernoux, T., Busch, W., Cui, H., Wang, J. Y., Blilou, I., Hassan, H., Nakajima, K., Matsumoto, N., Lohmann, J. U., Scheres, B., & Benfey, P. N. (2006). Whole-Genome Analysis of the SHORT-ROOT Developmental Pathway in Arabidopsis. PLoS Biology. https://doi.org/10.1371/journal.pbio.0040143
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