The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control
Open accessAbstract
The expression of certain genes involved in fundamental metabolism is regulated by metabolite-binding “riboswitch” elements embedded within their corresponding mRNAs. We have identified at least six additional elements within the Bacillus subtilis genome that exhibit characteristics of riboswitch function ( glmS , gcvT , ydaO/yuaA , ykkC/yxkD , ykoK , and yybP/ykoY ). These motifs exhibit extensive sequence and secondary-structure conservation among many bacterial species and occur upstream of related genes. The element located upstream of the glmS gene in Gram-positive organisms functions as a metabolite-dependent ribozyme that responds to glucosamine-6-phosphate. Other motifs form complex folded structures when transcribed as RNA molecules and carry intrinsic terminator structures. These findings indicate that riboswitches serve as a major genetic regulatory mechanism for the control of metabolic genes in many microbial species.
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Cites
Adenine riboswitches and gene activation by disruption of a transcription terminator
Mandal, M., & Breaker, R. R. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb710 · Cited by 514
Self-citationGlobal analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon
Baichoo, N., Wang, T., Ye, R., & Helmann, J. D. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03113.x · Cited by 250
Cited by
Prospects for riboswitch discovery and analysis
Breaker, R. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.024 · Cited by 464
Self-citationStructure and Mechanism of a Metal-Sensing Regulatory RNA
Dann, C. E., Wakeman, C. A., Sieling, C. L., Baker, S. C., Irnov, I., & Winkler, W. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.051 · Cited by 386
Self-citationWeinberg, Z., Wang, J. X., Bogue, J., Yang, J., Corbino, K., Moy, R. H., & Breaker, R. R. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r31 · Cited by 354
Self-citationIn-Line Probing Analysis of Riboswitches
Regulski, E. E., & Breaker, R. R. (2008) · Methods In Molecular Biology™ · doi:10.1007/978-1-59745-033-1_4 · Cited by 338
Self-citationWachter, A., Tunc-Ozdemir, M., Grove, B. C., Green, P. J., Shintani, D. K., & Breaker, R. R. (2007) · The Plant Cell · doi:10.1105/tpc.107.053645 · Cited by 331
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Metadata
- Authors
- Barrick, J. E., Corbino, K. A., Winkler, W. C., Nahvi, A., Mandal, M., Collins, J., Lee, M., Roth, A., Sudarsan, N., Jona, I., Wickiser, J. K., & Breaker, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-19
- Volume
- 101
- Issue
- 17
- Pages
- 6421-6426
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2122282339
- Cited by
- 498
- References
- 2
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Barrick, J. E., Corbino, K. A., Winkler, W. C., Nahvi, A., Mandal, M., Collins, J., Lee, M., Roth, A., Sudarsan, N., Jona, I., Wickiser, J. K., & Breaker, R. R. (2004). New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308014101
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