The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs
Open accessAbstract
The most widespread riboswitch class, found in organisms from all three domains of life, is responsive to the vitamin B1 derivative thiamin pyrophosphate (TPP). We have established that a TPP-sensing riboswitch is present in the 3′ untranslated region (UTR) of the thiamin biosynthetic gene THIC of all plant species examined. The THIC TPP riboswitch controls the formation of transcripts with alternative 3′ UTR lengths, which affect mRNA accumulation and protein production. We demonstrate that riboswitch-mediated regulation of alternative 3′ end processing is critical for TPP-dependent feedback control of THIC expression. Our data reveal a mechanism whereby metabolite-dependent alteration of RNA folding controls splicing and alternative 3′ end processing of mRNAs. These findings highlight the importance of metabolite sensing by riboswitches in plants and further reveal the significance of alternative 3′ end processing as a mechanism of gene control in eukaryotes.
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Self-citationGene regulation by riboswitches
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Self-citationREGULATION OF BACTERIAL GENE EXPRESSION BY RIBOSWITCHES
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Self-citationSerganov, A., Yuan, Y.-R., Pikovskaya, O., Polonskaia, A., Malinina, L., Phan, A. T., Hobartner, C., Micura, R., Breaker, R. R., & Patel, D. J. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.11.018 · Cited by 558
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Prospects for riboswitch discovery and analysis
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Self-citationThemes and variations in riboswitch structure and function
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Metadata
- Authors
- Wachter, A., Tunc-Ozdemir, M., Grove, B. C., Green, P. J., Shintani, D. K., & Breaker, R. R.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-01
- Volume
- 19
- Issue
- 11
- Pages
- 3437-3450
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2132939808
- Cited by
- 331
- References
- 40
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wachter, A., Tunc-Ozdemir, M., Grove, B. C., Green, P. J., Shintani, D. K., & Breaker, R. R. (2007). Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs. The Plant Cell. https://doi.org/10.1105/tpc.107.053645
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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