The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling
Open accessAbstract
The Bmp4 signaling molecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardium, suggesting a role for Bmp4 in OFT development. Inactivation of Bmp4 in the caudal branchial arch and splanchnic mesoderm and OFT myocardium by using a conditional null allele of Bmp4 and the Nkx2.5 cre recombinase allele resulted in abnormal morphogenesis of branchial-arch arteries (BAAs) and defective OFT septation. Expression of aortic-sac myocardial markers was reduced and expression of the sm22 LacZ transgene, a smooth-muscle marker, was attenuated in BAAs and conotruncus of Nkx2.5 cre ; Bmp4 conditional mutants. Moreover, we found tissue-specific functions for Bmp4 in the regulation of cellular proliferation and apoptosis. We also demonstrate a strong genetic interaction between Bmp4 and Bmp7 in OFT development. Our findings uncover a previously uncharacterized function for Bmp4 in vascular remodeling of the BAAs, and they show definitively that Bmp4 , in cooperation with Bmp7 , has a central role in OFT septation.
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Cites
Etchevers, H. C., Vincent, C., Douarin, N. M. L., & F. Couly, G. (2001) · Development · doi:10.1242/dev.128.7.1059 · Cited by 657
An essential role of Bmp4 in the atrioventricular septation of the mouse heart
Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H. S., & Hogan, B. L. M. (2003) · Genes & Development · doi:10.1101/gad.1124803 · Cited by 366
Cited by
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Bandyopadhyay, A., Tsuji, K., Cox, K., Harfe, B. D., Rosen, V., & Tabin, C. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020216 · Cited by 624
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
Lickert, H., Takeuchi, J. K., von Both, I., Walls, J. R., McAuliffe, F., Lee Adamson, S., Mark Henkelman, R., Wrana, J. L., Rossant, J., & Bruneau, B. G. (2004) · Nature · doi:10.1038/nature03071 · Cited by 548
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
Ma, L., Lu, M.-F., Schwartz, R. J., & Martin, J. F. (2005) · Development · doi:10.1242/dev.02156 · Cited by 525
Self-citationBlitz, E., Viukov, S., Sharir, A., Shwartz, Y., Galloway, J. L., Pryce, B. A., Johnson, R. L., Tabin, C. J., Schweitzer, R., & Zelzer, E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.010 · Cited by 297
Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis
Klaus, A., Saga, Y., Taketo, M. M., Tzahor, E., & Birchmeier, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703113104 · Cited by 278
Metadata
- Authors
- Liu, W., Selever, J., Wang, D., Lu, M.-F., Moses, K. A., Schwartz, R. J., & Martin, J. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-03-19
- Volume
- 101
- Issue
- 13
- Pages
- 4489-4494
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974261580
- Cited by
- 236
- References
- 2
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, W., Selever, J., Wang, D., Lu, M.-F., Moses, K. A., Schwartz, R. J., & Martin, J. F. (2004). Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308466101
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